Nucleic acid selection as a tool for drug discovery
Nucleic acid selection has proven to be an extremely versatile technique for the isolation of aptamers that can bind tightly and specifically to target molecules. Aptamers can modulate cellular physiology and have begun to be developed for therapeutic applications. Aptamers have also begun to be use...
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| Veröffentlicht in: | Drug discovery today 1998-06, Vol.3 (6), p.265-273 |
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| container_title | Drug discovery today |
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| creator | Bacher, Jamie M Ellington, Andrew D |
| description | Nucleic acid selection has proven to be an extremely versatile technique for the isolation of aptamers that can bind tightly and specifically to target molecules. Aptamers can modulate cellular physiology and have begun to be developed for therapeutic applications. Aptamers have also begun to be used as research reagents for the detection and localization of proteins. Moreover, because nucleic acid selection can quickly yield compounds that have unique properties and that can be applied in unique roles, this technique should generally be used as a tool to augment drug discovery efforts. |
| doi_str_mv | 10.1016/S1359-6446(97)01166-5 |
| format | Article |
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Aptamers can modulate cellular physiology and have begun to be developed for therapeutic applications. Aptamers have also begun to be used as research reagents for the detection and localization of proteins. Moreover, because nucleic acid selection can quickly yield compounds that have unique properties and that can be applied in unique roles, this technique should generally be used as a tool to augment drug discovery efforts.</description><subject>aptamers</subject><subject>Biological and medical sciences</subject><subject>diagnostics</subject><subject>General pharmacology</subject><subject>in vitro selection</subject><subject>Medical sciences</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>reverse drug discovery</subject><subject>SELEX</subject><subject>target validation</subject><subject>therapeutics</subject><issn>1359-6446</issn><issn>1878-5832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqFkEtLAzEQx4MoWKsfQdiDiB5W89hkk5NI8QVFD_YessmsRLabmuwW-u1NbfXqaebwm_k_EDon-IZgIm7fCeOqFFUlrlR9jQkRouQHaEJkLUsuGT3M-y9yjE5S-sSYUMXFBLHX0XbgbWGsd0WCDuzgQ1-YVJhiCKEr2hALF8ePwvlkwxri5hQdtaZLcLafU7R4fFjMnsv529PL7H5eWibqoVSKCiopVWCsAY4r3jggBJSRJBuhTDZM5llVspHWNkYK6yyYJntzDNgUXe7ermL4GiENepkdQNeZHsKYNBEc1wTXGeQ70MaQUoRWr6JfmrjRBOttQ_qnIb2Nr1WtfxrSPN9d7AVMsqZro-mtT3_HlFFSqy12t8MgZ117iDpZD70F52NuS7vg_xH6BtdbeSY</recordid><startdate>19980601</startdate><enddate>19980601</enddate><creator>Bacher, Jamie M</creator><creator>Ellington, Andrew D</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>19980601</creationdate><title>Nucleic acid selection as a tool for drug discovery</title><author>Bacher, Jamie M ; Ellington, Andrew D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-992628229eacae5045bde11e9a81446238b38462448b8ccba86cdceab012d3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>aptamers</topic><topic>Biological and medical sciences</topic><topic>diagnostics</topic><topic>General pharmacology</topic><topic>in vitro selection</topic><topic>Medical sciences</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>reverse drug discovery</topic><topic>SELEX</topic><topic>target validation</topic><topic>therapeutics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bacher, Jamie M</creatorcontrib><creatorcontrib>Ellington, Andrew D</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Drug discovery today</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bacher, Jamie M</au><au>Ellington, Andrew D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nucleic acid selection as a tool for drug discovery</atitle><jtitle>Drug discovery today</jtitle><date>1998-06-01</date><risdate>1998</risdate><volume>3</volume><issue>6</issue><spage>265</spage><epage>273</epage><pages>265-273</pages><issn>1359-6446</issn><eissn>1878-5832</eissn><abstract>Nucleic acid selection has proven to be an extremely versatile technique for the isolation of aptamers that can bind tightly and specifically to target molecules. 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| fulltext | fulltext |
| identifier | ISSN: 1359-6446 |
| ispartof | Drug discovery today, 1998-06, Vol.3 (6), p.265-273 |
| issn | 1359-6446 1878-5832 |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | aptamers Biological and medical sciences diagnostics General pharmacology in vitro selection Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments reverse drug discovery SELEX target validation therapeutics |
| title | Nucleic acid selection as a tool for drug discovery |
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