An oncogenic point mutation confers high affinity ligand binding to the neu receptor. Implications for the generation of site heterogeneity

The neu protooncogene encodes a receptor tyrosine kinase homologous to the receptor for the epidermal growth factor. The oncogenic potential of neu is released upon chemical carcinogenesis, which replaces a glutamic acid for a valine residue, within the single transmembrane domain. This results in c...

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