Diethylbenzene inhalation-induced electrophysiological deficits in peripheral nerves and changes in brainstem auditory evoked potentials in rats
Motor and sensory conduction velocities (MCV and SCV), amplitude of the sensory action potential (ASAP) of the tail nerve and parameters of brainstem auditory evoked potentials (BAEP) were studied in male Sprague‐Dawley rats after prolonged inhalation exposure to a commercial isomer mixture of dieth...
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| Veröffentlicht in: | Journal of applied toxicology 1992-10, Vol.12 (5), p.335-342 |
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| creator | Gagnaire, F. Becker, M. N. Marignac, B. Bonnet, P. de Ceaurriz, J. |
| description | Motor and sensory conduction velocities (MCV and SCV), amplitude of the sensory action potential (ASAP) of the tail nerve and parameters of brainstem auditory evoked potentials (BAEP) were studied in male Sprague‐Dawley rats after prolonged inhalation exposure to a commercial isomer mixture of diethylbenzene (DEB mixture) containing 6% 1, 2‐DEB. The MCV, SCV and ASAP were studied in one control group (10 rats) and three groups of 12 rats exposed to 500, 700 or 900 ppm DEB mixture for 6 h daily, 5 days per week, for 18 weeks. Rats used for recording BAEP (one control group and two other groups of 15 rats) were exposed to 600 and 800 ppm DEB mixture. The exposure time was the same.
Rats exposed to DEB mixture exhibited a time‐ and concentration‐dependent decrease in MCV, SCV and ASAP and a time‐ and concentration‐dependent increase of both the peak latencies of all BAEP components and the interpeak (I–V) differences. |
| doi_str_mv | 10.1002/jat.2550120509 |
| format | Article |
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Rats exposed to DEB mixture exhibited a time‐ and concentration‐dependent decrease in MCV, SCV and ASAP and a time‐ and concentration‐dependent increase of both the peak latencies of all BAEP components and the interpeak (I–V) differences.</description><identifier>ISSN: 0260-437X</identifier><identifier>EISSN: 1099-1263</identifier><identifier>DOI: 10.1002/jat.2550120509</identifier><identifier>PMID: 1332994</identifier><identifier>CODEN: JJATDK</identifier><language>eng</language><publisher>Chichester: John Wiley & Sons, Ltd</publisher><subject>Action Potentials - drug effects ; Action Potentials - physiology ; Administration, Inhalation ; Animals ; Benzene Derivatives - toxicity ; Biological and medical sciences ; brainstem auditory evoked potentials ; Central Nervous System Diseases - chemically induced ; Central Nervous System Diseases - physiopathology ; Chemical and industrial products toxicology. Toxic occupational diseases ; diethylbenzene ; Dose-Response Relationship, Drug ; Electrophysiology ; Evoked Potentials, Auditory, Brain Stem - drug effects ; inhalation exposure ; Male ; Medical sciences ; Motor Neurons - drug effects ; Motor Neurons - physiology ; nerve conduction velocity ; Neurons, Afferent - drug effects ; Neurons, Afferent - physiology ; neurotoxicity ; Peripheral Nervous System Diseases - chemically induced ; Peripheral Nervous System Diseases - physiopathology ; Psychomotor Performance - drug effects ; Psychomotor Performance - physiology ; Rats ; Rats, Sprague-Dawley ; Synaptic Transmission - drug effects ; Synaptic Transmission - physiology ; Toxicology ; Various organic compounds</subject><ispartof>Journal of applied toxicology, 1992-10, Vol.12 (5), p.335-342</ispartof><rights>Copyright © 1992 John Wiley & Sons, Ltd.</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3539-fa502ce3c9c2c1ef74e8d7c29ad3ed9f7494502dda434360eacd8eb9b93d1b783</citedby><cites>FETCH-LOGICAL-c3539-fa502ce3c9c2c1ef74e8d7c29ad3ed9f7494502dda434360eacd8eb9b93d1b783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjat.2550120509$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjat.2550120509$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5553941$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1332994$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gagnaire, F.</creatorcontrib><creatorcontrib>Becker, M. N.</creatorcontrib><creatorcontrib>Marignac, B.</creatorcontrib><creatorcontrib>Bonnet, P.</creatorcontrib><creatorcontrib>de Ceaurriz, J.</creatorcontrib><title>Diethylbenzene inhalation-induced electrophysiological deficits in peripheral nerves and changes in brainstem auditory evoked potentials in rats</title><title>Journal of applied toxicology</title><addtitle>J. Appl. Toxicol</addtitle><description>Motor and sensory conduction velocities (MCV and SCV), amplitude of the sensory action potential (ASAP) of the tail nerve and parameters of brainstem auditory evoked potentials (BAEP) were studied in male Sprague‐Dawley rats after prolonged inhalation exposure to a commercial isomer mixture of diethylbenzene (DEB mixture) containing 6% 1, 2‐DEB. The MCV, SCV and ASAP were studied in one control group (10 rats) and three groups of 12 rats exposed to 500, 700 or 900 ppm DEB mixture for 6 h daily, 5 days per week, for 18 weeks. Rats used for recording BAEP (one control group and two other groups of 15 rats) were exposed to 600 and 800 ppm DEB mixture. The exposure time was the same.
Rats exposed to DEB mixture exhibited a time‐ and concentration‐dependent decrease in MCV, SCV and ASAP and a time‐ and concentration‐dependent increase of both the peak latencies of all BAEP components and the interpeak (I–V) differences.</description><subject>Action Potentials - drug effects</subject><subject>Action Potentials - physiology</subject><subject>Administration, Inhalation</subject><subject>Animals</subject><subject>Benzene Derivatives - toxicity</subject><subject>Biological and medical sciences</subject><subject>brainstem auditory evoked potentials</subject><subject>Central Nervous System Diseases - chemically induced</subject><subject>Central Nervous System Diseases - physiopathology</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>diethylbenzene</subject><subject>Dose-Response Relationship, Drug</subject><subject>Electrophysiology</subject><subject>Evoked Potentials, Auditory, Brain Stem - drug effects</subject><subject>inhalation exposure</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Motor Neurons - drug effects</subject><subject>Motor Neurons - physiology</subject><subject>nerve conduction velocity</subject><subject>Neurons, Afferent - drug effects</subject><subject>Neurons, Afferent - physiology</subject><subject>neurotoxicity</subject><subject>Peripheral Nervous System Diseases - chemically induced</subject><subject>Peripheral Nervous System Diseases - physiopathology</subject><subject>Psychomotor Performance - drug effects</subject><subject>Psychomotor Performance - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Synaptic Transmission - drug effects</subject><subject>Synaptic Transmission - physiology</subject><subject>Toxicology</subject><subject>Various organic compounds</subject><issn>0260-437X</issn><issn>1099-1263</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1TAQhS0EKpfClh1SFohdbv3Iy8uqQAsq5aGLithYjj1p3ObawXYK4Vfwk2uaq1asWFnj-c4Zew5CzwleE4zpwaWMa1qWmFBcYv4ArQjmPCe0Yg_RCtMK5wWrvz1GT0K4xDj1aLOH9ghjlPNihf68NhD7eWjB_gYLmbG9HGQ0zubG6kmBzmAAFb0b-zkYN7gLo-SQaeiMMjEkQTaCN2MPPl1b8NcQMml1pnppL-AWaL00NkTYZnLSJjo_Z3DtrpL36CLYaORwy3kZw1P0qEslPNud--jr2zebo5P89OPxu6PD01yxkvG8kyWmCpjiiioCXV1Ao2tFudQMNE81LxKhtSxYwSoMUukGWt5ypklbN2wfvVp8R-9-TBCi2JqgYBikBTcFQaqCN5QWCVwvoPIuBA-dGL3ZSj8LgsXfCESKQNxHkAQvds5TuwV9jy87T_2Xu74MaZWdl1aZcIeVZfpfQRLGF-ynGWD-z1Dx_nDzzxPyRWvS1n_daaW_ElXN6lKcnx2LT2efNx9Ozr-LL-wGu6Gz8A</recordid><startdate>199210</startdate><enddate>199210</enddate><creator>Gagnaire, F.</creator><creator>Becker, M. N.</creator><creator>Marignac, B.</creator><creator>Bonnet, P.</creator><creator>de Ceaurriz, J.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>199210</creationdate><title>Diethylbenzene inhalation-induced electrophysiological deficits in peripheral nerves and changes in brainstem auditory evoked potentials in rats</title><author>Gagnaire, F. ; Becker, M. N. ; Marignac, B. ; Bonnet, P. ; de Ceaurriz, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3539-fa502ce3c9c2c1ef74e8d7c29ad3ed9f7494502dda434360eacd8eb9b93d1b783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Action Potentials - drug effects</topic><topic>Action Potentials - physiology</topic><topic>Administration, Inhalation</topic><topic>Animals</topic><topic>Benzene Derivatives - toxicity</topic><topic>Biological and medical sciences</topic><topic>brainstem auditory evoked potentials</topic><topic>Central Nervous System Diseases - chemically induced</topic><topic>Central Nervous System Diseases - physiopathology</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>diethylbenzene</topic><topic>Dose-Response Relationship, Drug</topic><topic>Electrophysiology</topic><topic>Evoked Potentials, Auditory, Brain Stem - drug effects</topic><topic>inhalation exposure</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Motor Neurons - drug effects</topic><topic>Motor Neurons - physiology</topic><topic>nerve conduction velocity</topic><topic>Neurons, Afferent - drug effects</topic><topic>Neurons, Afferent - physiology</topic><topic>neurotoxicity</topic><topic>Peripheral Nervous System Diseases - chemically induced</topic><topic>Peripheral Nervous System Diseases - physiopathology</topic><topic>Psychomotor Performance - drug effects</topic><topic>Psychomotor Performance - physiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Synaptic Transmission - drug effects</topic><topic>Synaptic Transmission - physiology</topic><topic>Toxicology</topic><topic>Various organic compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gagnaire, F.</creatorcontrib><creatorcontrib>Becker, M. N.</creatorcontrib><creatorcontrib>Marignac, B.</creatorcontrib><creatorcontrib>Bonnet, P.</creatorcontrib><creatorcontrib>de Ceaurriz, J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of applied toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gagnaire, F.</au><au>Becker, M. N.</au><au>Marignac, B.</au><au>Bonnet, P.</au><au>de Ceaurriz, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diethylbenzene inhalation-induced electrophysiological deficits in peripheral nerves and changes in brainstem auditory evoked potentials in rats</atitle><jtitle>Journal of applied toxicology</jtitle><addtitle>J. Appl. Toxicol</addtitle><date>1992-10</date><risdate>1992</risdate><volume>12</volume><issue>5</issue><spage>335</spage><epage>342</epage><pages>335-342</pages><issn>0260-437X</issn><eissn>1099-1263</eissn><coden>JJATDK</coden><abstract>Motor and sensory conduction velocities (MCV and SCV), amplitude of the sensory action potential (ASAP) of the tail nerve and parameters of brainstem auditory evoked potentials (BAEP) were studied in male Sprague‐Dawley rats after prolonged inhalation exposure to a commercial isomer mixture of diethylbenzene (DEB mixture) containing 6% 1, 2‐DEB. The MCV, SCV and ASAP were studied in one control group (10 rats) and three groups of 12 rats exposed to 500, 700 or 900 ppm DEB mixture for 6 h daily, 5 days per week, for 18 weeks. Rats used for recording BAEP (one control group and two other groups of 15 rats) were exposed to 600 and 800 ppm DEB mixture. The exposure time was the same.
Rats exposed to DEB mixture exhibited a time‐ and concentration‐dependent decrease in MCV, SCV and ASAP and a time‐ and concentration‐dependent increase of both the peak latencies of all BAEP components and the interpeak (I–V) differences.</abstract><cop>Chichester</cop><pub>John Wiley & Sons, Ltd</pub><pmid>1332994</pmid><doi>10.1002/jat.2550120509</doi><tpages>8</tpages></addata></record> |
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| subjects | Action Potentials - drug effects Action Potentials - physiology Administration, Inhalation Animals Benzene Derivatives - toxicity Biological and medical sciences brainstem auditory evoked potentials Central Nervous System Diseases - chemically induced Central Nervous System Diseases - physiopathology Chemical and industrial products toxicology. Toxic occupational diseases diethylbenzene Dose-Response Relationship, Drug Electrophysiology Evoked Potentials, Auditory, Brain Stem - drug effects inhalation exposure Male Medical sciences Motor Neurons - drug effects Motor Neurons - physiology nerve conduction velocity Neurons, Afferent - drug effects Neurons, Afferent - physiology neurotoxicity Peripheral Nervous System Diseases - chemically induced Peripheral Nervous System Diseases - physiopathology Psychomotor Performance - drug effects Psychomotor Performance - physiology Rats Rats, Sprague-Dawley Synaptic Transmission - drug effects Synaptic Transmission - physiology Toxicology Various organic compounds |
| title | Diethylbenzene inhalation-induced electrophysiological deficits in peripheral nerves and changes in brainstem auditory evoked potentials in rats |
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