Antimutagenic activity of carotenoids in green peppers against some nitroarenes
In Mexico, as well as in Central and South American countries, the consumption of peppers ( Capsicum annuum) has been tradition for thousands of years; the per capita dietary intake of peppers is about 40 g/day. Peppers are an important source of β-carotene and vitamin A, which have antimutagenic an...
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| description | In Mexico, as well as in Central and South American countries, the consumption of peppers (
Capsicum annuum) has been tradition for thousands of years; the per capita dietary intake of peppers is about 40 g/day. Peppers are an important source of β-carotene and vitamin A, which have antimutagenic and/or anticarcinogenic properties. In the present study,
Salmonella typhimurium tester strain YG1024 in the plate-incorporation test was used to examine the antimutagenicity of carotenoids extracted from five different types of
Capsicum spp. (`Chilaca', `Poblano', `Serrano', `Jalapeño' and `Pimiento') which were chosen, based on their consumption and availability on the local market. Extracts from these peppers were tested against 1-nitropyrene (1-NP); 1,6-dinitropyrene (1,6-DNP) and 1,8-dinitropyrene (1,8-DNP) mutagenicity. Dose–response mutagenicity curves of 1-NP; 1,6-DNP and 1,8-DNP were obtained. For the antimutagenicity studies, doses of 0.05 μg/plate, 0.20 ng/plate and 0.06 ng/plate for 1-NP, 1,6-DNP and 1,8-DNP respectively were chosen, and the number of net revertants/plate were 1008 for 1-NP, 512 for 1,6-DNP, and 712 for 1,8-DNP.
Trans-β-carotene and the extracts were not toxic to the bacteria at the concentrations tested. The extracts obtained from the peppers showed more inhibition than pure
trans-β-carotene on 1-NP; 1,6-DNP and 1,8-DNP mutagenicity. Chilaca pepper extract required 0.36 g (34 nmol expressed as
trans-β-carotene equivalents) of fresh pepper to inhibit 94% on 1-NP mutagenicity, 78% on 1,6-DNP mutagenicity and 84% on 1,8-DNP mutagenicity. Bell pepper (`Pimiento') extract required 1.53 g (50 nmol expressed as
trans-β-carotene) to obtain 87%, 79% and 73% inhibition on 1-NP; 1,6-DNP and 1,8-DNP mutagenicity respectively. Since pure β-carotene inhibited only approximately 50% the mutagenicity of nitroarenes, these results suggest that each one of the pepper extracts have more than one antimutagenic compound (e.g., β-carotene and xanthophylls) and those functional nutrients apparently have a synergistic effect. |
| doi_str_mv | 10.1016/S1383-5718(98)00070-9 |
| format | Article |
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Capsicum annuum) has been tradition for thousands of years; the per capita dietary intake of peppers is about 40 g/day. Peppers are an important source of β-carotene and vitamin A, which have antimutagenic and/or anticarcinogenic properties. In the present study,
Salmonella typhimurium tester strain YG1024 in the plate-incorporation test was used to examine the antimutagenicity of carotenoids extracted from five different types of
Capsicum spp. (`Chilaca', `Poblano', `Serrano', `Jalapeño' and `Pimiento') which were chosen, based on their consumption and availability on the local market. Extracts from these peppers were tested against 1-nitropyrene (1-NP); 1,6-dinitropyrene (1,6-DNP) and 1,8-dinitropyrene (1,8-DNP) mutagenicity. Dose–response mutagenicity curves of 1-NP; 1,6-DNP and 1,8-DNP were obtained. For the antimutagenicity studies, doses of 0.05 μg/plate, 0.20 ng/plate and 0.06 ng/plate for 1-NP, 1,6-DNP and 1,8-DNP respectively were chosen, and the number of net revertants/plate were 1008 for 1-NP, 512 for 1,6-DNP, and 712 for 1,8-DNP.
Trans-β-carotene and the extracts were not toxic to the bacteria at the concentrations tested. The extracts obtained from the peppers showed more inhibition than pure
trans-β-carotene on 1-NP; 1,6-DNP and 1,8-DNP mutagenicity. Chilaca pepper extract required 0.36 g (34 nmol expressed as
trans-β-carotene equivalents) of fresh pepper to inhibit 94% on 1-NP mutagenicity, 78% on 1,6-DNP mutagenicity and 84% on 1,8-DNP mutagenicity. Bell pepper (`Pimiento') extract required 1.53 g (50 nmol expressed as
trans-β-carotene) to obtain 87%, 79% and 73% inhibition on 1-NP; 1,6-DNP and 1,8-DNP mutagenicity respectively. Since pure β-carotene inhibited only approximately 50% the mutagenicity of nitroarenes, these results suggest that each one of the pepper extracts have more than one antimutagenic compound (e.g., β-carotene and xanthophylls) and those functional nutrients apparently have a synergistic effect.</description><identifier>ISSN: 1383-5718</identifier><identifier>ISSN: 0027-5107</identifier><identifier>EISSN: 1879-3592</identifier><identifier>DOI: 10.1016/S1383-5718(98)00070-9</identifier><identifier>PMID: 9725989</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Antimutagenic Agents - administration & dosage ; Antimutagenic Agents - isolation & purification ; Antimutagenic Agents - pharmacology ; ANTIMUTAGENS ; beta Carotene - administration & dosage ; beta Carotene - pharmacology ; Biological and medical sciences ; Capsicum - chemistry ; CAPSICUM ANNUUM ; Carotenoid ; CAROTENOIDS ; Carotenoids - administration & dosage ; Carotenoids - isolation & purification ; Carotenoids - pharmacology ; Dose-Response Relationship, Drug ; FOOD INTAKE ; Food toxicology ; MANKIND ; Medical sciences ; Mutagenicity ; Mutagenicity Tests ; Mutagens - toxicity ; Mutation ; Nitroarene ; Pepper ; Plants, Medicinal ; Pyrenes - toxicity ; Salmonella typhimurium ; Salmonella typhimurium - drug effects ; Salmonella typhimurium - genetics ; Toxicology</subject><ispartof>Mutation research, 1998-08, Vol.416 (1), p.11-19</ispartof><rights>1998 Elsevier Science B.V.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-ddc1b05a2222d5a4a820488fc71b88deb7e8cfb6f41efdcb4fbd8f17b1f10f193</citedby><cites>FETCH-LOGICAL-c442t-ddc1b05a2222d5a4a820488fc71b88deb7e8cfb6f41efdcb4fbd8f17b1f10f193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1383-5718(98)00070-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2433216$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9725989$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gonzalez de Mejia, E</creatorcontrib><creatorcontrib>Quintanar-Hernandez, JA</creatorcontrib><creatorcontrib>Loarca-Pina, G</creatorcontrib><title>Antimutagenic activity of carotenoids in green peppers against some nitroarenes</title><title>Mutation research</title><addtitle>Mutat Res</addtitle><description>In Mexico, as well as in Central and South American countries, the consumption of peppers (
Capsicum annuum) has been tradition for thousands of years; the per capita dietary intake of peppers is about 40 g/day. Peppers are an important source of β-carotene and vitamin A, which have antimutagenic and/or anticarcinogenic properties. In the present study,
Salmonella typhimurium tester strain YG1024 in the plate-incorporation test was used to examine the antimutagenicity of carotenoids extracted from five different types of
Capsicum spp. (`Chilaca', `Poblano', `Serrano', `Jalapeño' and `Pimiento') which were chosen, based on their consumption and availability on the local market. Extracts from these peppers were tested against 1-nitropyrene (1-NP); 1,6-dinitropyrene (1,6-DNP) and 1,8-dinitropyrene (1,8-DNP) mutagenicity. Dose–response mutagenicity curves of 1-NP; 1,6-DNP and 1,8-DNP were obtained. For the antimutagenicity studies, doses of 0.05 μg/plate, 0.20 ng/plate and 0.06 ng/plate for 1-NP, 1,6-DNP and 1,8-DNP respectively were chosen, and the number of net revertants/plate were 1008 for 1-NP, 512 for 1,6-DNP, and 712 for 1,8-DNP.
Trans-β-carotene and the extracts were not toxic to the bacteria at the concentrations tested. The extracts obtained from the peppers showed more inhibition than pure
trans-β-carotene on 1-NP; 1,6-DNP and 1,8-DNP mutagenicity. Chilaca pepper extract required 0.36 g (34 nmol expressed as
trans-β-carotene equivalents) of fresh pepper to inhibit 94% on 1-NP mutagenicity, 78% on 1,6-DNP mutagenicity and 84% on 1,8-DNP mutagenicity. Bell pepper (`Pimiento') extract required 1.53 g (50 nmol expressed as
trans-β-carotene) to obtain 87%, 79% and 73% inhibition on 1-NP; 1,6-DNP and 1,8-DNP mutagenicity respectively. Since pure β-carotene inhibited only approximately 50% the mutagenicity of nitroarenes, these results suggest that each one of the pepper extracts have more than one antimutagenic compound (e.g., β-carotene and xanthophylls) and those functional nutrients apparently have a synergistic effect.</description><subject>Antimutagenic Agents - administration & dosage</subject><subject>Antimutagenic Agents - isolation & purification</subject><subject>Antimutagenic Agents - pharmacology</subject><subject>ANTIMUTAGENS</subject><subject>beta Carotene - administration & dosage</subject><subject>beta Carotene - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Capsicum - chemistry</subject><subject>CAPSICUM ANNUUM</subject><subject>Carotenoid</subject><subject>CAROTENOIDS</subject><subject>Carotenoids - administration & dosage</subject><subject>Carotenoids - isolation & purification</subject><subject>Carotenoids - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>FOOD INTAKE</subject><subject>Food toxicology</subject><subject>MANKIND</subject><subject>Medical sciences</subject><subject>Mutagenicity</subject><subject>Mutagenicity Tests</subject><subject>Mutagens - toxicity</subject><subject>Mutation</subject><subject>Nitroarene</subject><subject>Pepper</subject><subject>Plants, Medicinal</subject><subject>Pyrenes - toxicity</subject><subject>Salmonella typhimurium</subject><subject>Salmonella typhimurium - drug effects</subject><subject>Salmonella typhimurium - genetics</subject><subject>Toxicology</subject><issn>1383-5718</issn><issn>0027-5107</issn><issn>1879-3592</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2LFDEQhoMo67r6ExZyENFDa6W_kpxkWfyCwT2o51CdVIbIdNImmYX999uzM65H65KC96mq8DB2KeC9ADF--CE61TWDFOqtVu8AQEKjn7BzoaRuukG3T9f-L_KcvSjlN0ALHagzdqZlO2ilz9nNVaxh3lfcUgyWo63hNtQ7njy3mFOlmIIrPES-zUSRL7QslAvHLYZYKi9pJh5DzQkzRSov2TOPu0KvTu8F-_X508_rr83m5su366tNY_u-rY1zVkwwYLuWG7BH1UKvlLdSTEo5miQp66fR94K8s1PvJ6e8kJPwArzQ3QV7c9y75PRnT6WaORRLux1GSvtixNjrAcYDOBxBm1MpmbxZcpgx3xkB5iDSPIg0B0tGK_Mg0hzmLk8H9tNM7nHqZG7NX59yLBZ3PmO0oTxibd91rRj_rfGYDG7zinzfCK0VwChBrvnHY06rrNtA2RQbKFpyIZOtxqXwn4_eA3esmig</recordid><startdate>19980807</startdate><enddate>19980807</enddate><creator>Gonzalez de Mejia, E</creator><creator>Quintanar-Hernandez, JA</creator><creator>Loarca-Pina, G</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19980807</creationdate><title>Antimutagenic activity of carotenoids in green peppers against some nitroarenes</title><author>Gonzalez de Mejia, E ; Quintanar-Hernandez, JA ; Loarca-Pina, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-ddc1b05a2222d5a4a820488fc71b88deb7e8cfb6f41efdcb4fbd8f17b1f10f193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Antimutagenic Agents - administration & dosage</topic><topic>Antimutagenic Agents - isolation & purification</topic><topic>Antimutagenic Agents - pharmacology</topic><topic>ANTIMUTAGENS</topic><topic>beta Carotene - administration & dosage</topic><topic>beta Carotene - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Capsicum - chemistry</topic><topic>CAPSICUM ANNUUM</topic><topic>Carotenoid</topic><topic>CAROTENOIDS</topic><topic>Carotenoids - administration & dosage</topic><topic>Carotenoids - isolation & purification</topic><topic>Carotenoids - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>FOOD INTAKE</topic><topic>Food toxicology</topic><topic>MANKIND</topic><topic>Medical sciences</topic><topic>Mutagenicity</topic><topic>Mutagenicity Tests</topic><topic>Mutagens - toxicity</topic><topic>Mutation</topic><topic>Nitroarene</topic><topic>Pepper</topic><topic>Plants, Medicinal</topic><topic>Pyrenes - toxicity</topic><topic>Salmonella typhimurium</topic><topic>Salmonella typhimurium - drug effects</topic><topic>Salmonella typhimurium - genetics</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gonzalez de Mejia, E</creatorcontrib><creatorcontrib>Quintanar-Hernandez, JA</creatorcontrib><creatorcontrib>Loarca-Pina, G</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Mutation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gonzalez de Mejia, E</au><au>Quintanar-Hernandez, JA</au><au>Loarca-Pina, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimutagenic activity of carotenoids in green peppers against some nitroarenes</atitle><jtitle>Mutation research</jtitle><addtitle>Mutat Res</addtitle><date>1998-08-07</date><risdate>1998</risdate><volume>416</volume><issue>1</issue><spage>11</spage><epage>19</epage><pages>11-19</pages><issn>1383-5718</issn><issn>0027-5107</issn><eissn>1879-3592</eissn><abstract>In Mexico, as well as in Central and South American countries, the consumption of peppers (
Capsicum annuum) has been tradition for thousands of years; the per capita dietary intake of peppers is about 40 g/day. Peppers are an important source of β-carotene and vitamin A, which have antimutagenic and/or anticarcinogenic properties. In the present study,
Salmonella typhimurium tester strain YG1024 in the plate-incorporation test was used to examine the antimutagenicity of carotenoids extracted from five different types of
Capsicum spp. (`Chilaca', `Poblano', `Serrano', `Jalapeño' and `Pimiento') which were chosen, based on their consumption and availability on the local market. Extracts from these peppers were tested against 1-nitropyrene (1-NP); 1,6-dinitropyrene (1,6-DNP) and 1,8-dinitropyrene (1,8-DNP) mutagenicity. Dose–response mutagenicity curves of 1-NP; 1,6-DNP and 1,8-DNP were obtained. For the antimutagenicity studies, doses of 0.05 μg/plate, 0.20 ng/plate and 0.06 ng/plate for 1-NP, 1,6-DNP and 1,8-DNP respectively were chosen, and the number of net revertants/plate were 1008 for 1-NP, 512 for 1,6-DNP, and 712 for 1,8-DNP.
Trans-β-carotene and the extracts were not toxic to the bacteria at the concentrations tested. The extracts obtained from the peppers showed more inhibition than pure
trans-β-carotene on 1-NP; 1,6-DNP and 1,8-DNP mutagenicity. Chilaca pepper extract required 0.36 g (34 nmol expressed as
trans-β-carotene equivalents) of fresh pepper to inhibit 94% on 1-NP mutagenicity, 78% on 1,6-DNP mutagenicity and 84% on 1,8-DNP mutagenicity. Bell pepper (`Pimiento') extract required 1.53 g (50 nmol expressed as
trans-β-carotene) to obtain 87%, 79% and 73% inhibition on 1-NP; 1,6-DNP and 1,8-DNP mutagenicity respectively. Since pure β-carotene inhibited only approximately 50% the mutagenicity of nitroarenes, these results suggest that each one of the pepper extracts have more than one antimutagenic compound (e.g., β-carotene and xanthophylls) and those functional nutrients apparently have a synergistic effect.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>9725989</pmid><doi>10.1016/S1383-5718(98)00070-9</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Mutation research, 1998-08, Vol.416 (1), p.11-19 |
| issn | 1383-5718 0027-5107 1879-3592 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16495069 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Antimutagenic Agents - administration & dosage Antimutagenic Agents - isolation & purification Antimutagenic Agents - pharmacology ANTIMUTAGENS beta Carotene - administration & dosage beta Carotene - pharmacology Biological and medical sciences Capsicum - chemistry CAPSICUM ANNUUM Carotenoid CAROTENOIDS Carotenoids - administration & dosage Carotenoids - isolation & purification Carotenoids - pharmacology Dose-Response Relationship, Drug FOOD INTAKE Food toxicology MANKIND Medical sciences Mutagenicity Mutagenicity Tests Mutagens - toxicity Mutation Nitroarene Pepper Plants, Medicinal Pyrenes - toxicity Salmonella typhimurium Salmonella typhimurium - drug effects Salmonella typhimurium - genetics Toxicology |
| title | Antimutagenic activity of carotenoids in green peppers against some nitroarenes |
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