An Essential Heparin-Binding Domain in the Fibroblast Growth Factor Receptor Kinase

Heparin or heparin-like heparan sulfate proteoglycans are obligatory for activity of the heparin-binding fibroblast growth factor (FGF) family. Heparin interacts independently of FGF ligand with a specific sequence (K18K) in one of the immunoglobulin-like loops in the extracellular domain of the FGF...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 1993-03, Vol.259 (5103), p.1918-1921
Hauptverfasser:	Kan, Mikio, Wang, Fen, Xu, Jianming, Crabb, John W., Hou, Jinzhao, McKeehan, Wallace L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Antibodies Antibodies, Monoclonal binding Binding Sites Biological and medical sciences Cell receptors Cell structures and functions Complementary DNA COS cells domains fibroblast growth factor receptor kinase Fibroblast growth factor receptors Fibroblast growth factors Fibroblast Growth Factors - metabolism Fundamental and applied biological sciences. Psychology Hep G2 cells Heparan Sulfate Proteoglycans Heparin Heparin - metabolism Heparitin Sulfate - metabolism Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors Humans Immunohistochemistry Ligands Lysine - metabolism man Metalloendopeptidases - metabolism Molecular and cellular biology Molecular Sequence Data Mutagenesis Peptide Fragments - isolation & purification Peptide Fragments - metabolism point mutation Protein-Tyrosine Kinases - chemistry Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Proteoglycans - metabolism Receptors Receptors, Fibroblast Growth Factor - chemistry Receptors, Fibroblast Growth Factor - genetics Receptors, Fibroblast Growth Factor - metabolism Recombinant Proteins - metabolism Sodium Chloride - pharmacology structure Sulfates Trypsin - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!