De novo design of α-helical coiled coils and bundles: models for the development of protein-design principles
The de novo design of model α-helical proteins from first principles has proved to be a useful approach to studying the short- and long-range noncovalent interactions that control the folding, stability, conformational changes and biological functions of proteins. These synthetic proteins are also p...
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| Veröffentlicht in: | Trends in biotechnology (Regular ed.) 1998-09, Vol.16 (9), p.379-389 |
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| container_end_page | 389 |
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| container_issue | 9 |
| container_start_page | 379 |
| container_title | Trends in biotechnology (Regular ed.) |
| container_volume | 16 |
| creator | Kohn, Wayne D. Hodges, Robert S. |
| description | The
de novo design of model α-helical proteins from first principles has proved to be a useful approach to studying the short- and long-range noncovalent interactions that control the folding, stability, conformational changes and biological functions of proteins. These synthetic proteins are also pointing the way towards a host of potential applications. Here, we review recent progress in the development of design principles with model proteins and discuss briefly some of the potential applications for this technology. |
| doi_str_mv | 10.1016/S0167-7799(98)01212-8 |
| format | Article |
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de novo design of model α-helical proteins from first principles has proved to be a useful approach to studying the short- and long-range noncovalent interactions that control the folding, stability, conformational changes and biological functions of proteins. These synthetic proteins are also pointing the way towards a host of potential applications. Here, we review recent progress in the development of design principles with model proteins and discuss briefly some of the potential applications for this technology.</description><subject>alpha-helix</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>coiled-coil</subject><subject>Conformational dynamics in molecular biology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>helical bundle</subject><subject>Methods. Procedures. Technologies</subject><subject>Molecular biophysics</subject><subject>protein design</subject><subject>Protein engineering</subject><subject>protein folding</subject><issn>0167-7799</issn><issn>1879-3096</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqFkMtKBDEQRYMoOI5-gpCFiC5ak34lcSPiGwQX6jrkUa2RnmRMegb8LH_EbzLzQJduqqC491bVQWifkhNKaHv6lAsrGBPiSPBjQktaFnwDjShnoqiIaDfR6FeyjXZSeieEVEzQEfJXgH2YB2whuVePQ4e_v4o36J1RPTbB9WCXLWHlLdYzb3tIZ3gSLORZFyIe3iC759CH6QT8sIiYxjCA88U6dBqdN26ajbtoq1N9gr11H6OXm-vny7vi4fH2_vLioTA1qYcCqCas5IwpwrUSDShaC16LDgwQDtyUura6NFQ1IJTltiWa6aZqtBZQNrQao8NVbr7kYwZpkBOXDPS98hBmSdK2FhUrqyxsVkITQ0oROpmPnaj4KSmRC7pySVcu0EnB5ZKu5Nl3sF6gUibVRZU_TH_mlrSciCw7X8kyLJg7iDIZB96AdRHMIG1w_yz6ARtYkMU</recordid><startdate>19980901</startdate><enddate>19980901</enddate><creator>Kohn, Wayne D.</creator><creator>Hodges, Robert S.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>19980901</creationdate><title>De novo design of α-helical coiled coils and bundles: models for the development of protein-design principles</title><author>Kohn, Wayne D. ; Hodges, Robert S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-e1b072877a08ba95ea149849fece08e8c2b4db2c1a5e9ad8d60b7b535bb9e2513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>alpha-helix</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>coiled-coil</topic><topic>Conformational dynamics in molecular biology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>helical bundle</topic><topic>Methods. Procedures. Technologies</topic><topic>Molecular biophysics</topic><topic>protein design</topic><topic>Protein engineering</topic><topic>protein folding</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kohn, Wayne D.</creatorcontrib><creatorcontrib>Hodges, Robert S.</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Trends in biotechnology (Regular ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kohn, Wayne D.</au><au>Hodges, Robert S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>De novo design of α-helical coiled coils and bundles: models for the development of protein-design principles</atitle><jtitle>Trends in biotechnology (Regular ed.)</jtitle><date>1998-09-01</date><risdate>1998</risdate><volume>16</volume><issue>9</issue><spage>379</spage><epage>389</epage><pages>379-389</pages><issn>0167-7799</issn><eissn>1879-3096</eissn><coden>TRBIDM</coden><abstract>The
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| ispartof | Trends in biotechnology (Regular ed.), 1998-09, Vol.16 (9), p.379-389 |
| issn | 0167-7799 1879-3096 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete |
| subjects | alpha-helix Biological and medical sciences Biotechnology coiled-coil Conformational dynamics in molecular biology Fundamental and applied biological sciences. Psychology helical bundle Methods. Procedures. Technologies Molecular biophysics protein design Protein engineering protein folding |
| title | De novo design of α-helical coiled coils and bundles: models for the development of protein-design principles |
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