Surface distribution and internalization of erbB-2 Proteins

We report the localization over the cell surface and the early steps of antibody-induced internalization of the product of the erbB-2 proto-oncogene, structurally related to the epidermal growth factor receptor (EGFR). We show that erbB-2/p185 is mostly excluded from endocytic pits on the cell surfa...

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Veröffentlicht in:	Experimental cell research 1992-10, Vol.202 (2), p.274-280
Hauptverfasser:	Lotti, Lavinia Vittoria, Di Lazzaro, Claudia, Zompetta, Claudia, Frati, Luigi, Torrisi, Maria Rosaria
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Antibodies, Monoclonal - immunology Biological and medical sciences Cell Membrane - metabolism Cell physiology Endocytosis Epidermal Growth Factor - physiology ErbB Receptors - genetics ErbB Receptors - metabolism Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Mice Molecular and cellular biology Mutagenesis Phagocytosis Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - immunology Proto-Oncogene Proteins - metabolism Receptor, ErbB-2 Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism
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