Potentiating interactions between morphogenetic protein and neurotrophic factors in developing neurons
mRNA for bone morphogenetic protein receptor type II (BMPR‐II) was mapped to different neurons in peripheral ganglia and spinal cord of the chicken embryo. The expression of this serine/threonine kinase receptor partially overlaps with that of tyrosine kinase receptors Trk and Ret. Biological activi...
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| Veröffentlicht in: | Journal of neuroscience research 1998-09, Vol.53 (5), p.559-568 |
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| creator | Bengtsson, Henrik Söderström, Stine Kylberg, Annika Charette, Marc F. Ebendal, Ted |
| description | mRNA for bone morphogenetic protein receptor type II (BMPR‐II) was mapped to different neurons in peripheral ganglia and spinal cord of the chicken embryo. The expression of this serine/threonine kinase receptor partially overlaps with that of tyrosine kinase receptors Trk and Ret. Biological activities of osteogenic protein‐1 (OP‐1), a documented ligand for BMPR‐II, were tested in explanted embryonic chicken ganglia and dissociated ganglionic neurons. OP‐1 had only a limited stimulatory effect on neuronal survival. However, OP‐1 combined with either neurotrophin‐3 (NT‐3, a relative of nerve growth factor) or glial cell line–derived neurotrophic factor (GDNF) potentiated neuronal survival three‐ to fourfold. We also show that OP‐1 strongly potentiates nerve fiber outgrowth from ganglia stimulated with NT‐3 or GDNF. Signaling by BMPR‐II in neurons may potentiate the tyrosine kinase pathway activated by NT‐3 and GDNF. The data suggest that morphogenetic proteins may modulate neurotrophic activities during neuronal development and plasticity. J. Neurosci. Res. 53:559–568, 1998. © 1998 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1097-4547(19980901)53:5<559::AID-JNR6>3.0.CO;2-8 |
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The expression of this serine/threonine kinase receptor partially overlaps with that of tyrosine kinase receptors Trk and Ret. Biological activities of osteogenic protein‐1 (OP‐1), a documented ligand for BMPR‐II, were tested in explanted embryonic chicken ganglia and dissociated ganglionic neurons. OP‐1 had only a limited stimulatory effect on neuronal survival. However, OP‐1 combined with either neurotrophin‐3 (NT‐3, a relative of nerve growth factor) or glial cell line–derived neurotrophic factor (GDNF) potentiated neuronal survival three‐ to fourfold. We also show that OP‐1 strongly potentiates nerve fiber outgrowth from ganglia stimulated with NT‐3 or GDNF. Signaling by BMPR‐II in neurons may potentiate the tyrosine kinase pathway activated by NT‐3 and GDNF. The data suggest that morphogenetic proteins may modulate neurotrophic activities during neuronal development and plasticity. J. Neurosci. Res. 53:559–568, 1998. © 1998 Wiley‐Liss, Inc.</description><identifier>ISSN: 0360-4012</identifier><identifier>EISSN: 1097-4547</identifier><identifier>DOI: 10.1002/(SICI)1097-4547(19980901)53:5<559::AID-JNR6>3.0.CO;2-8</identifier><identifier>PMID: 9726427</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Amino Acid Sequence ; Animals ; BMPR-II ; Bone Morphogenetic Protein 7 ; bone morphogenetic protein receptor type II ; Bone Morphogenetic Protein Receptors, Type II ; Bone Morphogenetic Proteins - pharmacology ; Cell Survival - drug effects ; Cells, Cultured ; Chick Embryo ; Drosophila Proteins ; Drug Synergism ; Ganglia, Autonomic ; Ganglia, Sensory ; GDNF ; Gene Expression Regulation ; glial cell line-derived neurotrophic factor ; Glial Cell Line-Derived Neurotrophic Factor Receptors ; In Situ Hybridization ; Molecular Sequence Data ; Nerve Growth Factors - genetics ; Nerve Tissue Proteins - pharmacology ; Neurites - drug effects ; Neurons - cytology ; Neurons - drug effects ; neurotrophin-3 ; NT-3 ; Oncogene Proteins - genetics ; OP-1 ; osteogenic protein-1 ; Protein-Serine-Threonine Kinases - genetics ; Proto-Oncogene Proteins - genetics ; Proto-Oncogene Proteins c-ret ; Receptor Protein-Tyrosine Kinases - genetics ; Receptors, Cell Surface - genetics ; serine/threonine kinase receptors ; Transforming Growth Factor beta</subject><ispartof>Journal of neuroscience research, 1998-09, Vol.53 (5), p.559-568</ispartof><rights>Copyright © 1998 Wiley‐Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291097-4547%2819980901%2953%3A5%3C559%3A%3AAID-JNR6%3E3.0.CO%3B2-8$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291097-4547%2819980901%2953%3A5%3C559%3A%3AAID-JNR6%3E3.0.CO%3B2-8$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9726427$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bengtsson, Henrik</creatorcontrib><creatorcontrib>Söderström, Stine</creatorcontrib><creatorcontrib>Kylberg, Annika</creatorcontrib><creatorcontrib>Charette, Marc F.</creatorcontrib><creatorcontrib>Ebendal, Ted</creatorcontrib><title>Potentiating interactions between morphogenetic protein and neurotrophic factors in developing neurons</title><title>Journal of neuroscience research</title><addtitle>J. Neurosci. Res</addtitle><description>mRNA for bone morphogenetic protein receptor type II (BMPR‐II) was mapped to different neurons in peripheral ganglia and spinal cord of the chicken embryo. The expression of this serine/threonine kinase receptor partially overlaps with that of tyrosine kinase receptors Trk and Ret. Biological activities of osteogenic protein‐1 (OP‐1), a documented ligand for BMPR‐II, were tested in explanted embryonic chicken ganglia and dissociated ganglionic neurons. OP‐1 had only a limited stimulatory effect on neuronal survival. However, OP‐1 combined with either neurotrophin‐3 (NT‐3, a relative of nerve growth factor) or glial cell line–derived neurotrophic factor (GDNF) potentiated neuronal survival three‐ to fourfold. We also show that OP‐1 strongly potentiates nerve fiber outgrowth from ganglia stimulated with NT‐3 or GDNF. Signaling by BMPR‐II in neurons may potentiate the tyrosine kinase pathway activated by NT‐3 and GDNF. The data suggest that morphogenetic proteins may modulate neurotrophic activities during neuronal development and plasticity. J. Neurosci. Res. 53:559–568, 1998. © 1998 Wiley‐Liss, Inc.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>BMPR-II</subject><subject>Bone Morphogenetic Protein 7</subject><subject>bone morphogenetic protein receptor type II</subject><subject>Bone Morphogenetic Protein Receptors, Type II</subject><subject>Bone Morphogenetic Proteins - pharmacology</subject><subject>Cell Survival - drug effects</subject><subject>Cells, Cultured</subject><subject>Chick Embryo</subject><subject>Drosophila Proteins</subject><subject>Drug Synergism</subject><subject>Ganglia, Autonomic</subject><subject>Ganglia, Sensory</subject><subject>GDNF</subject><subject>Gene Expression Regulation</subject><subject>glial cell line-derived neurotrophic factor</subject><subject>Glial Cell Line-Derived Neurotrophic Factor Receptors</subject><subject>In Situ Hybridization</subject><subject>Molecular Sequence Data</subject><subject>Nerve Growth Factors - genetics</subject><subject>Nerve Tissue Proteins - pharmacology</subject><subject>Neurites - drug effects</subject><subject>Neurons - cytology</subject><subject>Neurons - drug effects</subject><subject>neurotrophin-3</subject><subject>NT-3</subject><subject>Oncogene Proteins - genetics</subject><subject>OP-1</subject><subject>osteogenic protein-1</subject><subject>Protein-Serine-Threonine Kinases - genetics</subject><subject>Proto-Oncogene Proteins - genetics</subject><subject>Proto-Oncogene Proteins c-ret</subject><subject>Receptor Protein-Tyrosine Kinases - genetics</subject><subject>Receptors, Cell Surface - genetics</subject><subject>serine/threonine kinase receptors</subject><subject>Transforming Growth Factor beta</subject><issn>0360-4012</issn><issn>1097-4547</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v00AQxVcIVELhIyD5hNqDw3j_2N6AKlUGSlDaIAJU4jJa2-PW4KyN16H027NuQjiAxGk12je_N3qPsZMIphEAf360mmfz4wh0Ekolk6NI6xQ0RMdKzNRLpfRsdjp_Fb67-BCfiClMs-ULHqb32GS_cp9NQMQQSoj4Q_bIua8AoLUSB-xAJzyWPJmw6n07kB1qM9T2KqjtQL0phrq1LshpuCGywbrtu-v2iiwNdRF0vV-obWBsGVja-Klvu2v_Ufm9tneeEZT0g5q2G4l3EusesweVaRw92b2H7NOb1x-zt-FieTbPThdhIbWOQy0SRbkpIuK85JSUZJQWFOdxmuclCFOBSKuygLQocpMLKdNSauIVcahMAuKQPdty_ZnfN-QGXNeuoKYxltqNwyiWmoOMvfDzVlj0rXM9Vdj19dr0txgBjgUgjgXgmCaOaeLvAlAJVOgLQPQF4FgACgTMlsgx9eCnuws2-ZrKPXaX-B_jm7qh279c_2v6D8-72YPDLbh2A_3cg03_DePE54qXF2eYLC5Xq_Nzjl_EL6gttBc</recordid><startdate>19980901</startdate><enddate>19980901</enddate><creator>Bengtsson, Henrik</creator><creator>Söderström, Stine</creator><creator>Kylberg, Annika</creator><creator>Charette, Marc F.</creator><creator>Ebendal, Ted</creator><general>John Wiley & Sons, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19980901</creationdate><title>Potentiating interactions between morphogenetic protein and neurotrophic factors in developing neurons</title><author>Bengtsson, Henrik ; Söderström, Stine ; Kylberg, Annika ; Charette, Marc F. ; Ebendal, Ted</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4996-9375ebac1e22d2e7dea593e6b68bbd03af038fdc08ccbab3448d49e2fe20fa703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>BMPR-II</topic><topic>Bone Morphogenetic Protein 7</topic><topic>bone morphogenetic protein receptor type II</topic><topic>Bone Morphogenetic Protein Receptors, Type II</topic><topic>Bone Morphogenetic Proteins - pharmacology</topic><topic>Cell Survival - drug effects</topic><topic>Cells, Cultured</topic><topic>Chick Embryo</topic><topic>Drosophila Proteins</topic><topic>Drug Synergism</topic><topic>Ganglia, Autonomic</topic><topic>Ganglia, Sensory</topic><topic>GDNF</topic><topic>Gene Expression Regulation</topic><topic>glial cell line-derived neurotrophic factor</topic><topic>Glial Cell Line-Derived Neurotrophic Factor Receptors</topic><topic>In Situ Hybridization</topic><topic>Molecular Sequence Data</topic><topic>Nerve Growth Factors - genetics</topic><topic>Nerve Tissue Proteins - pharmacology</topic><topic>Neurites - drug effects</topic><topic>Neurons - cytology</topic><topic>Neurons - drug effects</topic><topic>neurotrophin-3</topic><topic>NT-3</topic><topic>Oncogene Proteins - genetics</topic><topic>OP-1</topic><topic>osteogenic protein-1</topic><topic>Protein-Serine-Threonine Kinases - genetics</topic><topic>Proto-Oncogene Proteins - genetics</topic><topic>Proto-Oncogene Proteins c-ret</topic><topic>Receptor Protein-Tyrosine Kinases - genetics</topic><topic>Receptors, Cell Surface - genetics</topic><topic>serine/threonine kinase receptors</topic><topic>Transforming Growth Factor beta</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bengtsson, Henrik</creatorcontrib><creatorcontrib>Söderström, Stine</creatorcontrib><creatorcontrib>Kylberg, Annika</creatorcontrib><creatorcontrib>Charette, Marc F.</creatorcontrib><creatorcontrib>Ebendal, Ted</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of neuroscience research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bengtsson, Henrik</au><au>Söderström, Stine</au><au>Kylberg, Annika</au><au>Charette, Marc F.</au><au>Ebendal, Ted</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potentiating interactions between morphogenetic protein and neurotrophic factors in developing neurons</atitle><jtitle>Journal of neuroscience research</jtitle><addtitle>J. Neurosci. Res</addtitle><date>1998-09-01</date><risdate>1998</risdate><volume>53</volume><issue>5</issue><spage>559</spage><epage>568</epage><pages>559-568</pages><issn>0360-4012</issn><eissn>1097-4547</eissn><abstract>mRNA for bone morphogenetic protein receptor type II (BMPR‐II) was mapped to different neurons in peripheral ganglia and spinal cord of the chicken embryo. The expression of this serine/threonine kinase receptor partially overlaps with that of tyrosine kinase receptors Trk and Ret. Biological activities of osteogenic protein‐1 (OP‐1), a documented ligand for BMPR‐II, were tested in explanted embryonic chicken ganglia and dissociated ganglionic neurons. OP‐1 had only a limited stimulatory effect on neuronal survival. However, OP‐1 combined with either neurotrophin‐3 (NT‐3, a relative of nerve growth factor) or glial cell line–derived neurotrophic factor (GDNF) potentiated neuronal survival three‐ to fourfold. We also show that OP‐1 strongly potentiates nerve fiber outgrowth from ganglia stimulated with NT‐3 or GDNF. Signaling by BMPR‐II in neurons may potentiate the tyrosine kinase pathway activated by NT‐3 and GDNF. The data suggest that morphogenetic proteins may modulate neurotrophic activities during neuronal development and plasticity. J. Neurosci. Res. 53:559–568, 1998. © 1998 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>9726427</pmid><doi>10.1002/(SICI)1097-4547(19980901)53:5<559::AID-JNR6>3.0.CO;2-8</doi><tpages>10</tpages></addata></record> |
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| subjects | Amino Acid Sequence Animals BMPR-II Bone Morphogenetic Protein 7 bone morphogenetic protein receptor type II Bone Morphogenetic Protein Receptors, Type II Bone Morphogenetic Proteins - pharmacology Cell Survival - drug effects Cells, Cultured Chick Embryo Drosophila Proteins Drug Synergism Ganglia, Autonomic Ganglia, Sensory GDNF Gene Expression Regulation glial cell line-derived neurotrophic factor Glial Cell Line-Derived Neurotrophic Factor Receptors In Situ Hybridization Molecular Sequence Data Nerve Growth Factors - genetics Nerve Tissue Proteins - pharmacology Neurites - drug effects Neurons - cytology Neurons - drug effects neurotrophin-3 NT-3 Oncogene Proteins - genetics OP-1 osteogenic protein-1 Protein-Serine-Threonine Kinases - genetics Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-ret Receptor Protein-Tyrosine Kinases - genetics Receptors, Cell Surface - genetics serine/threonine kinase receptors Transforming Growth Factor beta |
| title | Potentiating interactions between morphogenetic protein and neurotrophic factors in developing neurons |
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