Upregulation of amyloid precursor protein gene promoter in rat primary hippocampal neurons by phorbol ester, IL-1 and retinoic acid, but not by reactive oxygen species

The APP gene promoter has multiple regulatory sequences, some of which may contribute to the neuropathology of Alzheimer's disease (AD). In this study, we investigated the effects of phorbol ester (PMA), IL-1, retinoic acid and reactive oxygen species on APP promoter activity in primary hippoca...

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Veröffentlicht in:	Brain research. Molecular brain research. 1998-09, Vol.60 (1), p.40-49
Hauptverfasser:	Yang, Yaxiong, Quitschke, Wolfgang W., Brewer, Gregory J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Amyloid precursor protein Animals Antineoplastic Agents - pharmacology Benzoflavones - pharmacology Biological and medical sciences Carcinogens - pharmacology Cation Exchange Resins Cell Survival - drug effects Cells, Cultured Curcumin - metabolism DNA - analysis Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Hippocampus - cytology Hydrogen Peroxide - metabolism Hydroquinones - pharmacology Indicators and Reagents Interleukin-1 - pharmacology Lipids Molecular and cellular biology Molecular genetics Mutagens - pharmacology Neurons - cytology Neurons - drug effects Neurons - metabolism NF-kappa B - metabolism NF-κB Oxidative stress Phorbol Esters - pharmacology Promoter Promoter Regions, Genetic - genetics Rat hippocampal neuron Rats Reactive Oxygen Species - metabolism Transcription. Transcription factor. Splicing. Rna processing Transfection Tretinoin - pharmacology Tumor Necrosis Factor-alpha - metabolism
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