The alternative product from the human CDKN2A locus, p14 ARF , participates in a regulatory feedback loop with p53 and MDM2

The two distinct proteins encoded by the CDKN2A locus are specified by translating the common second exon in alternative reading frames. The product of the alpha transcript, p16INK4a, is a recognized tumour suppressor that induces a G sub(1) cell cycle arrest by inhibiting the phosphorylation of the...

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Veröffentlicht in:	The EMBO journal 1998-09, Vol.17 (17), p.5001-5014
Hauptverfasser:	Peters, Gordon, Stott, Francesca J, Bates, Stewart, James, Marion C, McConnell, Beth B, Starborg, Maria, Brookes, Sharon, Palmero, Ignacio, Ryan, Kevin, Hara, Eiji, Vousden, Karen H
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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