Acyclovir for the Prevention of Recurrent Herpes Simplex Virus Eye Disease
Herpes simplex virus (HSV) is a leading cause of corneal opacification and infection-related visual loss. An estimated 400,000 Americans have had ocular HSV disease, and there are nearly 50,000 new and recurrent cases each year in the United States. 1 After the initial exposure and primary, often as...
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| Veröffentlicht in: | The New England journal of medicine 1998-07, Vol.339 (5), p.300-306 |
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| container_title | The New England journal of medicine |
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| creator | Wilhelmus, Kirk R Beck, Roy W Moke, Pamela S Dawson, Chandler R Barron, Bruce A Jones, Dan B Kaufman, Herbert E Kurinij, Natalie Stulting, R. Doyle Sugar, Joel Cohen, Elisabeth J Hyndiuk, Robert A Asbell, Penny A |
| description | Herpes simplex virus (HSV) is a leading cause of corneal opacification and infection-related visual loss. An estimated 400,000 Americans have had ocular HSV disease, and there are nearly 50,000 new and recurrent cases each year in the United States.
1
After the initial exposure and primary, often asymptomatic infection, HSV establishes a latent infection in the trigeminal or other sensory ganglia. Recurrent viral shedding can lead to disease of one or both eyes. Superficial ocular infection can involve the eyelids (blepharitis), conjunctiva (conjunctivitis), or corneal surface (dendritic or epithelial keratitis). Deeper involvement of the cornea (stromal keratitis) or anterior uvea (iritis) . . . |
| doi_str_mv | 10.1056/NEJM199807303390503 |
| format | Article |
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1
After the initial exposure and primary, often asymptomatic infection, HSV establishes a latent infection in the trigeminal or other sensory ganglia. Recurrent viral shedding can lead to disease of one or both eyes. Superficial ocular infection can involve the eyelids (blepharitis), conjunctiva (conjunctivitis), or corneal surface (dendritic or epithelial keratitis). Deeper involvement of the cornea (stromal keratitis) or anterior uvea (iritis) . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199807303390503</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral agents ; Biological and medical sciences ; Drug therapy ; Eyes & eyesight ; Herpes viruses ; Long term health care ; Medical sciences ; Pharmacology. Drug treatments</subject><ispartof>The New England journal of medicine, 1998-07, Vol.339 (5), p.300-306</ispartof><rights>Copyright © 1998 Massachusetts Medical Society. All rights reserved.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c592t-8c84660943b7ea911de309428f3d0d529d8d56a2b5f0bec4a35e9ae1d68a60063</citedby><cites>FETCH-LOGICAL-c592t-8c84660943b7ea911de309428f3d0d529d8d56a2b5f0bec4a35e9ae1d68a60063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199807303390503$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/223962129?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,781,785,2760,2761,26108,27929,27930,52387,54069,64390,64392,64394,72474</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2342204$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Wilhelmus, Kirk R</creatorcontrib><creatorcontrib>Beck, Roy W</creatorcontrib><creatorcontrib>Moke, Pamela S</creatorcontrib><creatorcontrib>Dawson, Chandler R</creatorcontrib><creatorcontrib>Barron, Bruce A</creatorcontrib><creatorcontrib>Jones, Dan B</creatorcontrib><creatorcontrib>Kaufman, Herbert E</creatorcontrib><creatorcontrib>Kurinij, Natalie</creatorcontrib><creatorcontrib>Stulting, R. Doyle</creatorcontrib><creatorcontrib>Sugar, Joel</creatorcontrib><creatorcontrib>Cohen, Elisabeth J</creatorcontrib><creatorcontrib>Hyndiuk, Robert A</creatorcontrib><creatorcontrib>Asbell, Penny A</creatorcontrib><title>Acyclovir for the Prevention of Recurrent Herpes Simplex Virus Eye Disease</title><title>The New England journal of medicine</title><description>Herpes simplex virus (HSV) is a leading cause of corneal opacification and infection-related visual loss. An estimated 400,000 Americans have had ocular HSV disease, and there are nearly 50,000 new and recurrent cases each year in the United States.
1
After the initial exposure and primary, often asymptomatic infection, HSV establishes a latent infection in the trigeminal or other sensory ganglia. Recurrent viral shedding can lead to disease of one or both eyes. Superficial ocular infection can involve the eyelids (blepharitis), conjunctiva (conjunctivitis), or corneal surface (dendritic or epithelial keratitis). Deeper involvement of the cornea (stromal keratitis) or anterior uvea (iritis) . . .</description><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral agents</subject><subject>Biological and medical sciences</subject><subject>Drug therapy</subject><subject>Eyes & eyesight</subject><subject>Herpes viruses</subject><subject>Long term health care</subject><subject>Medical sciences</subject><subject>Pharmacology. 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1
After the initial exposure and primary, often asymptomatic infection, HSV establishes a latent infection in the trigeminal or other sensory ganglia. Recurrent viral shedding can lead to disease of one or both eyes. Superficial ocular infection can involve the eyelids (blepharitis), conjunctiva (conjunctivitis), or corneal surface (dendritic or epithelial keratitis). Deeper involvement of the cornea (stromal keratitis) or anterior uvea (iritis) . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><doi>10.1056/NEJM199807303390503</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The New England journal of medicine, 1998-07, Vol.339 (5), p.300-306 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16488427 |
| source | EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Drug therapy Eyes & eyesight Herpes viruses Long term health care Medical sciences Pharmacology. Drug treatments |
| title | Acyclovir for the Prevention of Recurrent Herpes Simplex Virus Eye Disease |
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