Regulation of Mytilus galloprovincialis glycogen phosphorylase by glucose and glucose-6-phosphate

A different glucose and glucose-6-phosphate inhibition of glycogen phosphorylase from Mytilus mantle relative to those of vertebrates has been demonstrated. Glucose and glucose-6-phosphate do not inhibit the a form (phosphorylated form), but they are competitive inhibitors for the substrate glucose-...

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Veröffentlicht in:Journal of shellfish research 1998-06, Vol.17 (1), p.159-163
Hauptverfasser: Serrano, FSJ, Alonso, P S, Lopez, SLB, Martin, LOG
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container_title Journal of shellfish research
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creator Serrano, FSJ
Alonso, P S
Lopez, SLB
Martin, LOG
description A different glucose and glucose-6-phosphate inhibition of glycogen phosphorylase from Mytilus mantle relative to those of vertebrates has been demonstrated. Glucose and glucose-6-phosphate do not inhibit the a form (phosphorylated form), but they are competitive inhibitors for the substrate glucose-1-phosphate in the b form (unphosphorylated form), with Ki values of 190 and 0.2-0.3 mM, respectively. The results cast doubt on the role of glucose as a regulator and suggest that glucose-6-phosphate is a major regulator of glycogen phosphorylase activity in Mytilus mantle tissue because of its special relationship with gametogenesis.
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Mytilus galloprovincialis
title Regulation of Mytilus galloprovincialis glycogen phosphorylase by glucose and glucose-6-phosphate
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