Methyl Tertiary Butyl Ether-Induced Endocrine Alterations in Mice Are Not Mediated through the Estrogen Receptor

Chronic exposure to methyl tertiary butyl ether (MTBE) altered the rodent tumor incidence of endocrine-sensitive tissues and decreased the incidence of estrogen-dependent uterine cystic hyper-plasia in mice. To test the hypothesis that changes in the incidence of tumors in female B6C3F1 mice after M...

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Veröffentlicht in:	Toxicological sciences 1998-01, Vol.41 (1), p.77-87
Hauptverfasser:	Moser, Glenda J., Wolf, Douglas C., Sar, Madhabananda, Gaido, Kevin W., Janszen, Dervek, Goldsworthy, Thomas L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Animals Body Weight - drug effects Carcinogens - toxicity Cell Division - drug effects Cervix Uteri - drug effects Cervix Uteri - pathology DNA Replication - drug effects Endocrine Glands - drug effects Endocrine Glands - metabolism Endocrine Glands - pathology Estradiol - blood Estrus - drug effects Female Methyl Ethers - toxicity Mice Organ Size - drug effects Receptors, Estrogen - metabolism Vagina - drug effects Vagina - pathology
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