The D domain of the thyroid hormone receptor alpha 1 specifies positive and negative transcriptional regulation functions

Four structural domains are characteristic of the members of the thyroid/steroid receptor superfamily. Of these, the A/B and D domains are the least conserved. We have investigated the role of two clusters of positively charged amino acids within the D domain of the thyroid hormone receptor alpha 1...

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Veröffentlicht in:	The Journal of biological chemistry 1993-01, Vol.268 (3), p.2021-2028
Hauptverfasser:	Lee, Y, Mahdavi, V
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding Sites Blotting, Western Cell Line Cell Nucleus - metabolism Cytoplasm - metabolism DNA - metabolism Fluorescent Antibody Technique Gene Expression Regulation Immunosorbent Techniques Molecular Sequence Data Mutagenesis, Site-Directed Plasmids Rats Receptors, Thyroid Hormone - chemistry Receptors, Thyroid Hormone - genetics Receptors, Thyroid Hormone - physiology Transcription, Genetic Transfection Triiodothyronine - metabolism
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