Prevention of UVB-Induced Production of the Inflammatory Mediator in Human Keratinocytes by Lactic Acid Derivatives Generated from Aromatic Amino Acids
The anti-inflammatory effects of lactic acid derivatives were investigated on ultraviolet B (UVB)-irradiated HaCaT human keratinocytes. A pretreatment with indole-3-lactic acid (ILA) and 4-hydroxyphenyllactic acid (HPLA) inhibited the UVB-induced production of interlekin-6 (IL-6). The inhibitory eff...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2013, Vol.77 (8), p.1766-1768 |
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| container_issue | 8 |
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| container_title | Bioscience, biotechnology, and biochemistry |
| container_volume | 77 |
| creator | AOKI-YOSHIDA, Ayako ICHIDA, Kasumi AOKI, Reiji KAWASUMI, Toshiyuki SUZUKI, Chise TAKAYAMA, Yoshiharu |
| description | The anti-inflammatory effects of lactic acid derivatives were investigated on ultraviolet B (UVB)-irradiated HaCaT human keratinocytes. A pretreatment with indole-3-lactic acid (ILA) and 4-hydroxyphenyllactic acid (HPLA) inhibited the UVB-induced production of interlekin-6 (IL-6). The inhibitory effect of L-HPLA was equivalent to that of a corresponding racemic mixture (DL-HPLA), suggesting that optical isomerism did not affect the anti-inflammatory activity of HPLA. |
| doi_str_mv | 10.1271/bbb.120979 |
| format | Article |
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A pretreatment with indole-3-lactic acid (ILA) and 4-hydroxyphenyllactic acid (HPLA) inhibited the UVB-induced production of interlekin-6 (IL-6). The inhibitory effect of L-HPLA was equivalent to that of a corresponding racemic mixture (DL-HPLA), suggesting that optical isomerism did not affect the anti-inflammatory activity of HPLA.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.120979</identifier><identifier>PMID: 23924721</identifier><language>eng</language><publisher>England: Japan Society for Bioscience, Biotechnology, and Agrochemistry</publisher><subject>4-hydroxyphenyllactic acid ; Amino Acids, Aromatic ; Anti-Inflammatory Agents - administration & dosage ; aromatic amino acid ; Cell Line - drug effects ; Cell Line - radiation effects ; Humans ; indole-3-lactic acid ; Indoles - administration & dosage ; interleukin-6 (IL-6) ; keratinocyte ; Keratinocytes - drug effects ; Keratinocytes - radiation effects ; Phenylpropionates - administration & dosage ; RNA, Messenger - drug effects ; RNA, Messenger - metabolism ; Ultraviolet Rays</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2013, Vol.77 (8), p.1766-1768</ispartof><rights>2013 by Japan Society for Bioscience, Biotechnology, and Agrochemistry 2013</rights><rights>Copyright Japan Science and Technology Agency 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c648t-b33dbcce6318b463e74feb19ce9c5e7eec5518269e13bb1152566e750655660b3</citedby><cites>FETCH-LOGICAL-c648t-b33dbcce6318b463e74feb19ce9c5e7eec5518269e13bb1152566e750655660b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,4025,27928,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23924721$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>AOKI-YOSHIDA, Ayako</creatorcontrib><creatorcontrib>ICHIDA, Kasumi</creatorcontrib><creatorcontrib>AOKI, Reiji</creatorcontrib><creatorcontrib>KAWASUMI, Toshiyuki</creatorcontrib><creatorcontrib>SUZUKI, Chise</creatorcontrib><creatorcontrib>TAKAYAMA, Yoshiharu</creatorcontrib><title>Prevention of UVB-Induced Production of the Inflammatory Mediator in Human Keratinocytes by Lactic Acid Derivatives Generated from Aromatic Amino Acids</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>The anti-inflammatory effects of lactic acid derivatives were investigated on ultraviolet B (UVB)-irradiated HaCaT human keratinocytes. A pretreatment with indole-3-lactic acid (ILA) and 4-hydroxyphenyllactic acid (HPLA) inhibited the UVB-induced production of interlekin-6 (IL-6). The inhibitory effect of L-HPLA was equivalent to that of a corresponding racemic mixture (DL-HPLA), suggesting that optical isomerism did not affect the anti-inflammatory activity of HPLA.</description><subject>4-hydroxyphenyllactic acid</subject><subject>Amino Acids, Aromatic</subject><subject>Anti-Inflammatory Agents - administration & dosage</subject><subject>aromatic amino acid</subject><subject>Cell Line - drug effects</subject><subject>Cell Line - radiation effects</subject><subject>Humans</subject><subject>indole-3-lactic acid</subject><subject>Indoles - administration & dosage</subject><subject>interleukin-6 (IL-6)</subject><subject>keratinocyte</subject><subject>Keratinocytes - drug effects</subject><subject>Keratinocytes - radiation effects</subject><subject>Phenylpropionates - administration & dosage</subject><subject>RNA, Messenger - drug effects</subject><subject>RNA, Messenger - metabolism</subject><subject>Ultraviolet Rays</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS0EokNhwwMgS2wQUsB2_JMsh1LaEYPogrKNbOdGuIrtYieD8iR9XTwzLQuExMY-8vnuubIOQi8peUeZou-NMUWQVrWP0IrWXFWy5eoxWpGWyqrhgp6gZznfEFIeBH2KTljdMq4YXaG7qwQ7CJOLAccBX3__UG1CP1vo8VWKRTw40w_AmzCM2ns9xbTgL9C7vcIu4MvZ64A_Q9KTC9EuE2RsFrzVZdzitXU9_gjJ7Yq9K9YFhD1adgwperwuhz6Avkwf8PwcPRn0mOHF_X2Krj-dfzu7rLZfLzZn621lJW-mytR1b6wFWdPGcFmD4gMY2lporQAFYIWgDZMt0NoYSgUTUoISRIoiiKlP0Ztj7m2KP2fIU-ddtjCOOkCcc0clV4QJTuT_Uc4aQVt2QF__hd7EOYXykUKphjBJKCnU2yNlU8w5wdDdJud1WjpKun2zXWm2OzZb4Ff3kbPx0P9BH6osgDgCLgwxef0rprHvJr2MMQ1JB-tyV_8j-Dfe3bCx</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>AOKI-YOSHIDA, Ayako</creator><creator>ICHIDA, Kasumi</creator><creator>AOKI, Reiji</creator><creator>KAWASUMI, Toshiyuki</creator><creator>SUZUKI, Chise</creator><creator>TAKAYAMA, Yoshiharu</creator><general>Japan Society for Bioscience, Biotechnology, and Agrochemistry</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>2013</creationdate><title>Prevention of UVB-Induced Production of the Inflammatory Mediator in Human Keratinocytes by Lactic Acid Derivatives Generated from Aromatic Amino Acids</title><author>AOKI-YOSHIDA, Ayako ; ICHIDA, Kasumi ; AOKI, Reiji ; KAWASUMI, Toshiyuki ; SUZUKI, Chise ; TAKAYAMA, Yoshiharu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c648t-b33dbcce6318b463e74feb19ce9c5e7eec5518269e13bb1152566e750655660b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>4-hydroxyphenyllactic acid</topic><topic>Amino Acids, Aromatic</topic><topic>Anti-Inflammatory Agents - administration & dosage</topic><topic>aromatic amino acid</topic><topic>Cell Line - drug effects</topic><topic>Cell Line - radiation effects</topic><topic>Humans</topic><topic>indole-3-lactic acid</topic><topic>Indoles - administration & dosage</topic><topic>interleukin-6 (IL-6)</topic><topic>keratinocyte</topic><topic>Keratinocytes - drug effects</topic><topic>Keratinocytes - radiation effects</topic><topic>Phenylpropionates - administration & dosage</topic><topic>RNA, Messenger - drug effects</topic><topic>RNA, Messenger - metabolism</topic><topic>Ultraviolet Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AOKI-YOSHIDA, Ayako</creatorcontrib><creatorcontrib>ICHIDA, Kasumi</creatorcontrib><creatorcontrib>AOKI, Reiji</creatorcontrib><creatorcontrib>KAWASUMI, Toshiyuki</creatorcontrib><creatorcontrib>SUZUKI, Chise</creatorcontrib><creatorcontrib>TAKAYAMA, Yoshiharu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AOKI-YOSHIDA, Ayako</au><au>ICHIDA, Kasumi</au><au>AOKI, Reiji</au><au>KAWASUMI, Toshiyuki</au><au>SUZUKI, Chise</au><au>TAKAYAMA, Yoshiharu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevention of UVB-Induced Production of the Inflammatory Mediator in Human Keratinocytes by Lactic Acid Derivatives Generated from Aromatic Amino Acids</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2013</date><risdate>2013</risdate><volume>77</volume><issue>8</issue><spage>1766</spage><epage>1768</epage><pages>1766-1768</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>The anti-inflammatory effects of lactic acid derivatives were investigated on ultraviolet B (UVB)-irradiated HaCaT human keratinocytes. A pretreatment with indole-3-lactic acid (ILA) and 4-hydroxyphenyllactic acid (HPLA) inhibited the UVB-induced production of interlekin-6 (IL-6). The inhibitory effect of L-HPLA was equivalent to that of a corresponding racemic mixture (DL-HPLA), suggesting that optical isomerism did not affect the anti-inflammatory activity of HPLA.</abstract><cop>England</cop><pub>Japan Society for Bioscience, Biotechnology, and Agrochemistry</pub><pmid>23924721</pmid><doi>10.1271/bbb.120979</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0916-8451 |
| ispartof | Bioscience, biotechnology, and biochemistry, 2013, Vol.77 (8), p.1766-1768 |
| issn | 0916-8451 1347-6947 |
| language | eng |
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| source | J-STAGE Free; MEDLINE; Oxford University Press Journals All Titles (1996-Current); Freely Accessible Japanese Titles; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | 4-hydroxyphenyllactic acid Amino Acids, Aromatic Anti-Inflammatory Agents - administration & dosage aromatic amino acid Cell Line - drug effects Cell Line - radiation effects Humans indole-3-lactic acid Indoles - administration & dosage interleukin-6 (IL-6) keratinocyte Keratinocytes - drug effects Keratinocytes - radiation effects Phenylpropionates - administration & dosage RNA, Messenger - drug effects RNA, Messenger - metabolism Ultraviolet Rays |
| title | Prevention of UVB-Induced Production of the Inflammatory Mediator in Human Keratinocytes by Lactic Acid Derivatives Generated from Aromatic Amino Acids |
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