Prevalence of JC polyomavirus large T antigen sequences among Iranian patients with central nervous system tumors
The human neurotropic JC virus (JCV) is of significant interest due to its experimental neuro- oncogenic potential. In clinical samples from human central nervous system (CNS) tumors, detection of JCV sequences suggests a possible association with CNS neoplasms, but the results are discrepant worldw...
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| Veröffentlicht in: | Archives of virology 2015, Vol.160 (1), p.61-68 |
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| creator | Sadeghi, Farzin Salehi-Vaziri, Mostafa Ghodsi, Seyed Mohammad Alizadeh, Ahad Bokharaei-Salim, Farah Saroukalaei, Sedigheh Taghinezhad Mirbolouk, Mohammadhossein Monavari, Seyed Hamidreza Keyvani, Hossein |
| description | The human neurotropic JC virus (JCV) is of significant interest due to its experimental neuro- oncogenic potential. In clinical samples from human central nervous system (CNS) tumors, detection of JCV sequences suggests a possible association with CNS neoplasms, but the results are discrepant worldwide. To assess the prevalence of JCV sequences in Iranian patients with primary and metastatic CNS malignancies, a total of 58 fresh CNS tumors were examined by quantitative real-time PCR targeting the JCV large T antigen (LT-Ag) gene, and JCV DNA load was determined as viral copy number per cell. All patients were immunocompetent, and none of them had received immunosuppressive therapy before surgical operation. JC virus LT-Ag sequences were found in a total of 15 (25.9 %) out of the 58 tested samples. In primary CNS tumors, JCV sequences were identified more frequently in meningiomas (50.0 %) and schwannomas (35.7 %). In metastatic CNS tumors, JCV LT-Ag was identified in one case with brain adenocarcinoma originating from lung cancer. No statistically significant association between JCV positivity and various types of CNS malignancies was observed (P = 0.565). The mean JCV LT-Ag copy number in 15 positive cases was 1.8 × 10⁻⁴ ± 4.5 × 10⁻⁴copies per cell (range 1.0 × 10⁻⁵-1.78 × 10⁻³copies per cell). An inverse correlation between white blood cell (WBC) count and JCV copy number was observed, but this correlation was not statistically significant (R = −0.198, P = 0.480). This study provides the first data on the prevalence of JCV in primary and metastatic CNS tumors from Iranian patients. |
| doi_str_mv | 10.1007/s00705-014-2230-0 |
| format | Article |
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In clinical samples from human central nervous system (CNS) tumors, detection of JCV sequences suggests a possible association with CNS neoplasms, but the results are discrepant worldwide. To assess the prevalence of JCV sequences in Iranian patients with primary and metastatic CNS malignancies, a total of 58 fresh CNS tumors were examined by quantitative real-time PCR targeting the JCV large T antigen (LT-Ag) gene, and JCV DNA load was determined as viral copy number per cell. All patients were immunocompetent, and none of them had received immunosuppressive therapy before surgical operation. JC virus LT-Ag sequences were found in a total of 15 (25.9 %) out of the 58 tested samples. In primary CNS tumors, JCV sequences were identified more frequently in meningiomas (50.0 %) and schwannomas (35.7 %). In metastatic CNS tumors, JCV LT-Ag was identified in one case with brain adenocarcinoma originating from lung cancer. No statistically significant association between JCV positivity and various types of CNS malignancies was observed (P = 0.565). The mean JCV LT-Ag copy number in 15 positive cases was 1.8 × 10⁻⁴ ± 4.5 × 10⁻⁴copies per cell (range 1.0 × 10⁻⁵-1.78 × 10⁻³copies per cell). An inverse correlation between white blood cell (WBC) count and JCV copy number was observed, but this correlation was not statistically significant (R = −0.198, P = 0.480). This study provides the first data on the prevalence of JCV in primary and metastatic CNS tumors from Iranian patients.</description><identifier>ISSN: 0304-8608</identifier><identifier>EISSN: 1432-8798</identifier><identifier>DOI: 10.1007/s00705-014-2230-0</identifier><identifier>PMID: 25218012</identifier><language>eng</language><publisher>Vienna: Springer-Verlag</publisher><subject>adenocarcinoma ; Adult ; Aged ; Aged, 80 and over ; Antigens ; Antigens, Viral, Tumor - isolation & purification ; Biomedical and Life Sciences ; Biomedicine ; Biopsy ; brain ; Brain cancer ; Cell cycle ; Central Nervous System Neoplasms - epidemiology ; Central Nervous System Neoplasms - virology ; DNA ; DNA, Viral - isolation & purification ; Female ; genes ; Humans ; Immunocompetence ; Infections ; Infectious Diseases ; Investigations ; Iran - epidemiology ; JC polyomavirus ; JC virus ; JC Virus - genetics ; JC Virus - isolation & purification ; JC Virus - physiology ; leukocytes ; lung neoplasms ; Male ; Medical Microbiology ; Metastasis ; Middle Aged ; Nervous system ; Neurosurgery ; Original Article ; patients ; Polyomavirus ; Public health ; quantitative polymerase chain reaction ; Real-Time Polymerase Chain Reaction ; therapeutics ; Tumors ; Virology ; Viruses</subject><ispartof>Archives of virology, 2015, Vol.160 (1), p.61-68</ispartof><rights>Springer-Verlag Wien 2014</rights><rights>Springer-Verlag Wien 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-3b5b2aca9133bfa7ce76d35a72d3e14d8eb1518d20e6744519e21cbcf050796b3</citedby><cites>FETCH-LOGICAL-c429t-3b5b2aca9133bfa7ce76d35a72d3e14d8eb1518d20e6744519e21cbcf050796b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00705-014-2230-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00705-014-2230-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,4022,27921,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25218012$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sadeghi, Farzin</creatorcontrib><creatorcontrib>Salehi-Vaziri, Mostafa</creatorcontrib><creatorcontrib>Ghodsi, Seyed Mohammad</creatorcontrib><creatorcontrib>Alizadeh, Ahad</creatorcontrib><creatorcontrib>Bokharaei-Salim, Farah</creatorcontrib><creatorcontrib>Saroukalaei, Sedigheh Taghinezhad</creatorcontrib><creatorcontrib>Mirbolouk, Mohammadhossein</creatorcontrib><creatorcontrib>Monavari, Seyed Hamidreza</creatorcontrib><creatorcontrib>Keyvani, Hossein</creatorcontrib><title>Prevalence of JC polyomavirus large T antigen sequences among Iranian patients with central nervous system tumors</title><title>Archives of virology</title><addtitle>Arch Virol</addtitle><addtitle>Arch Virol</addtitle><description>The human neurotropic JC virus (JCV) is of significant interest due to its experimental neuro- oncogenic potential. In clinical samples from human central nervous system (CNS) tumors, detection of JCV sequences suggests a possible association with CNS neoplasms, but the results are discrepant worldwide. To assess the prevalence of JCV sequences in Iranian patients with primary and metastatic CNS malignancies, a total of 58 fresh CNS tumors were examined by quantitative real-time PCR targeting the JCV large T antigen (LT-Ag) gene, and JCV DNA load was determined as viral copy number per cell. All patients were immunocompetent, and none of them had received immunosuppressive therapy before surgical operation. JC virus LT-Ag sequences were found in a total of 15 (25.9 %) out of the 58 tested samples. In primary CNS tumors, JCV sequences were identified more frequently in meningiomas (50.0 %) and schwannomas (35.7 %). In metastatic CNS tumors, JCV LT-Ag was identified in one case with brain adenocarcinoma originating from lung cancer. No statistically significant association between JCV positivity and various types of CNS malignancies was observed (P = 0.565). The mean JCV LT-Ag copy number in 15 positive cases was 1.8 × 10⁻⁴ ± 4.5 × 10⁻⁴copies per cell (range 1.0 × 10⁻⁵-1.78 × 10⁻³copies per cell). An inverse correlation between white blood cell (WBC) count and JCV copy number was observed, but this correlation was not statistically significant (R = −0.198, P = 0.480). This study provides the first data on the prevalence of JCV in primary and metastatic CNS tumors from Iranian patients.</description><subject>adenocarcinoma</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antigens</subject><subject>Antigens, Viral, Tumor - isolation & purification</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biopsy</subject><subject>brain</subject><subject>Brain cancer</subject><subject>Cell cycle</subject><subject>Central Nervous System Neoplasms - epidemiology</subject><subject>Central Nervous System Neoplasms - virology</subject><subject>DNA</subject><subject>DNA, Viral - isolation & purification</subject><subject>Female</subject><subject>genes</subject><subject>Humans</subject><subject>Immunocompetence</subject><subject>Infections</subject><subject>Infectious Diseases</subject><subject>Investigations</subject><subject>Iran - epidemiology</subject><subject>JC polyomavirus</subject><subject>JC virus</subject><subject>JC Virus - genetics</subject><subject>JC Virus - isolation & purification</subject><subject>JC Virus - physiology</subject><subject>leukocytes</subject><subject>lung neoplasms</subject><subject>Male</subject><subject>Medical Microbiology</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Nervous system</subject><subject>Neurosurgery</subject><subject>Original Article</subject><subject>patients</subject><subject>Polyomavirus</subject><subject>Public health</subject><subject>quantitative polymerase chain reaction</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>therapeutics</subject><subject>Tumors</subject><subject>Virology</subject><subject>Viruses</subject><issn>0304-8608</issn><issn>1432-8798</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkk1v1DAQhi0EotvCD-AClrj0Epjxxzo5ohUfRZVAoj1bTjIJqRJ7ayeL9t_jVQpCHBAX27Kf952x3mHsBcIbBDBvU15AF4CqEEJCAY_YBpUURWmq8jHbgARVlFsoz9h5SncA-ULqp-xMaIEloNiw-6-RDm4k3xAPHf-84_swHsPkDkNcEh9d7InfcOfnoSfPE90vJzZxNwXf86vo_OA837t5ID8n_mOYv_MmH6Mbuad4CNklHdNME5-XKcT0jD3p3Jjo-cN-wW4_vL_ZfSquv3y82r27LholqrmQta6Fa1yFUtadMw2ZbSu1M6KVhKotqUaNZSuAtkYpjRUJbOqmAw2m2tbygl2uvvsYctNpttOQGhpH5yk3ZXGrDAgtK_0_qESlBIqMvv4LvQtL9PkjJ0qgNFqUmcKVamJIKVJn93GYXDxaBHuKzq7R2RydPUVnIWtePjgv9UTtb8WvrDIgViDlJ99T_KP0P1xfraLOBev6OCR7-00A6jwMlSnzPPwE1MmtDQ</recordid><startdate>2015</startdate><enddate>2015</enddate><creator>Sadeghi, Farzin</creator><creator>Salehi-Vaziri, Mostafa</creator><creator>Ghodsi, Seyed Mohammad</creator><creator>Alizadeh, Ahad</creator><creator>Bokharaei-Salim, Farah</creator><creator>Saroukalaei, Sedigheh Taghinezhad</creator><creator>Mirbolouk, Mohammadhossein</creator><creator>Monavari, Seyed Hamidreza</creator><creator>Keyvani, Hossein</creator><general>Springer-Verlag</general><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>2015</creationdate><title>Prevalence of JC polyomavirus large T antigen sequences among Iranian patients with central nervous system tumors</title><author>Sadeghi, Farzin ; Salehi-Vaziri, Mostafa ; Ghodsi, Seyed Mohammad ; Alizadeh, Ahad ; Bokharaei-Salim, Farah ; Saroukalaei, Sedigheh Taghinezhad ; Mirbolouk, Mohammadhossein ; Monavari, Seyed Hamidreza ; Keyvani, Hossein</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-3b5b2aca9133bfa7ce76d35a72d3e14d8eb1518d20e6744519e21cbcf050796b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>adenocarcinoma</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antigens</topic><topic>Antigens, Viral, Tumor - isolation & purification</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Biopsy</topic><topic>brain</topic><topic>Brain cancer</topic><topic>Cell cycle</topic><topic>Central Nervous System Neoplasms - epidemiology</topic><topic>Central Nervous System Neoplasms - virology</topic><topic>DNA</topic><topic>DNA, Viral - isolation & purification</topic><topic>Female</topic><topic>genes</topic><topic>Humans</topic><topic>Immunocompetence</topic><topic>Infections</topic><topic>Infectious Diseases</topic><topic>Investigations</topic><topic>Iran - epidemiology</topic><topic>JC polyomavirus</topic><topic>JC virus</topic><topic>JC Virus - genetics</topic><topic>JC Virus - isolation & purification</topic><topic>JC Virus - physiology</topic><topic>leukocytes</topic><topic>lung neoplasms</topic><topic>Male</topic><topic>Medical Microbiology</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Nervous system</topic><topic>Neurosurgery</topic><topic>Original Article</topic><topic>patients</topic><topic>Polyomavirus</topic><topic>Public health</topic><topic>quantitative polymerase chain reaction</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>therapeutics</topic><topic>Tumors</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sadeghi, Farzin</creatorcontrib><creatorcontrib>Salehi-Vaziri, Mostafa</creatorcontrib><creatorcontrib>Ghodsi, Seyed Mohammad</creatorcontrib><creatorcontrib>Alizadeh, Ahad</creatorcontrib><creatorcontrib>Bokharaei-Salim, Farah</creatorcontrib><creatorcontrib>Saroukalaei, Sedigheh Taghinezhad</creatorcontrib><creatorcontrib>Mirbolouk, Mohammadhossein</creatorcontrib><creatorcontrib>Monavari, Seyed Hamidreza</creatorcontrib><creatorcontrib>Keyvani, Hossein</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sadeghi, Farzin</au><au>Salehi-Vaziri, Mostafa</au><au>Ghodsi, Seyed Mohammad</au><au>Alizadeh, Ahad</au><au>Bokharaei-Salim, Farah</au><au>Saroukalaei, Sedigheh Taghinezhad</au><au>Mirbolouk, Mohammadhossein</au><au>Monavari, Seyed Hamidreza</au><au>Keyvani, Hossein</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of JC polyomavirus large T antigen sequences among Iranian patients with central nervous system tumors</atitle><jtitle>Archives of virology</jtitle><stitle>Arch Virol</stitle><addtitle>Arch Virol</addtitle><date>2015</date><risdate>2015</risdate><volume>160</volume><issue>1</issue><spage>61</spage><epage>68</epage><pages>61-68</pages><issn>0304-8608</issn><eissn>1432-8798</eissn><abstract>The human neurotropic JC virus (JCV) is of significant interest due to its experimental neuro- oncogenic potential. In clinical samples from human central nervous system (CNS) tumors, detection of JCV sequences suggests a possible association with CNS neoplasms, but the results are discrepant worldwide. To assess the prevalence of JCV sequences in Iranian patients with primary and metastatic CNS malignancies, a total of 58 fresh CNS tumors were examined by quantitative real-time PCR targeting the JCV large T antigen (LT-Ag) gene, and JCV DNA load was determined as viral copy number per cell. All patients were immunocompetent, and none of them had received immunosuppressive therapy before surgical operation. JC virus LT-Ag sequences were found in a total of 15 (25.9 %) out of the 58 tested samples. In primary CNS tumors, JCV sequences were identified more frequently in meningiomas (50.0 %) and schwannomas (35.7 %). In metastatic CNS tumors, JCV LT-Ag was identified in one case with brain adenocarcinoma originating from lung cancer. No statistically significant association between JCV positivity and various types of CNS malignancies was observed (P = 0.565). The mean JCV LT-Ag copy number in 15 positive cases was 1.8 × 10⁻⁴ ± 4.5 × 10⁻⁴copies per cell (range 1.0 × 10⁻⁵-1.78 × 10⁻³copies per cell). An inverse correlation between white blood cell (WBC) count and JCV copy number was observed, but this correlation was not statistically significant (R = −0.198, P = 0.480). This study provides the first data on the prevalence of JCV in primary and metastatic CNS tumors from Iranian patients.</abstract><cop>Vienna</cop><pub>Springer-Verlag</pub><pmid>25218012</pmid><doi>10.1007/s00705-014-2230-0</doi><tpages>8</tpages></addata></record> |
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| subjects | adenocarcinoma Adult Aged Aged, 80 and over Antigens Antigens, Viral, Tumor - isolation & purification Biomedical and Life Sciences Biomedicine Biopsy brain Brain cancer Cell cycle Central Nervous System Neoplasms - epidemiology Central Nervous System Neoplasms - virology DNA DNA, Viral - isolation & purification Female genes Humans Immunocompetence Infections Infectious Diseases Investigations Iran - epidemiology JC polyomavirus JC virus JC Virus - genetics JC Virus - isolation & purification JC Virus - physiology leukocytes lung neoplasms Male Medical Microbiology Metastasis Middle Aged Nervous system Neurosurgery Original Article patients Polyomavirus Public health quantitative polymerase chain reaction Real-Time Polymerase Chain Reaction therapeutics Tumors Virology Viruses |
| title | Prevalence of JC polyomavirus large T antigen sequences among Iranian patients with central nervous system tumors |
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