Therapeutic benefits of a component of coffee in a rat model of Alzheimer's disease

Abstract A minor component of coffee unrelated to caffeine, eicosanoyl-5-hydroxytryptamide (EHT), provides protection in a rat model for Alzheimer's disease (AD). In this model, viral expression of the phosphoprotein phosphatase 2A (PP2A) endogenous inhibitor, the I 2 PP 2 A , or SET protein in...

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Veröffentlicht in:	Neurobiology of aging 2014-12, Vol.35 (12), p.2701-2712
Hauptverfasser:	Basurto-Islas, Gustavo, Blanchard, Julie, Tung, Yunn Chyn, Fernandez, Jose R, Voronkov, Michael, Stock, Maxwell, Zhang, Sherry, Stock, Jeffry B, Iqbal, Khalid
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoassociated virus vector serotype 1 Alzheimer Disease - prevention & control Animals Coffee Coffee - chemistry Cognitive impairment Disease Models, Animal Eicosanoyl-5-hydroxytryptamide Female Hyperphosphorylation of tau Inhibitor-2 of protein phosphatase-2A Internal Medicine Methylation - drug effects Methylation of protein phosphatase-2A Neurology Neuroprotective Agents Protein Phosphatase 2 - metabolism Protein phosphatase-2A Rat model of sporadic Alzheimer’s disease Rats Rats, Transgenic Serotonin - analogs & derivatives Serotonin - pharmacology Serotonin - therapeutic use SET Tau
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