Targeting mitochondria with methylene blue protects mice against acetaminophen‐induced liver injury

Acetaminophen (APAP) overdose is a frequent cause of drug‐induced liver injury and the most frequent cause of acute liver failure in the Western world. Previous studies with mouse models have revealed that impairment of mitochondrial respiration is an early event in the pathogenesis, but the exact m...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2015-01, Vol.61 (1), p.326-336
Hauptverfasser:	Lee, Kang Kwang, Imaizumi, Naoki, Chamberland, Sally R., Alder, Nathan N., Boelsterli, Urs A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - adverse effects Analgesics, Non-Narcotic - adverse effects Animals Benzoquinones - adverse effects Cell Death - drug effects Cells, Cultured Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - pathology Chemical and Drug Induced Liver Injury - prevention & control Drug Evaluation, Preclinical Electron Transport Complex II - antagonists & inhibitors Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Hepatocytes - drug effects Hepatology Imines - adverse effects Liver - drug effects Liver - pathology Male Methylene Blue - pharmacology Methylene Blue - therapeutic use Mice, Inbred C57BL Mitochondria, Liver - drug effects Mitochondria, Liver - metabolism Necrosis - prevention & control Peroxynitrous Acid - metabolism Succinate Dehydrogenase - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!