25-hydroxyvitamin D3 status is associated with developing adaptive and innate immune responses in the first 6 months of life
Summary Background Vitamin D (25[OH]D3) status in early life has been linked to the risk of allergic disease in multiple observational studies. While immunomodulating properties are well recognized, there are few longitudinal studies of 25(OH)D3 status, immune function and allergic disease in infant...
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| Veröffentlicht in: | Clinical and experimental allergy 2015-01, Vol.45 (1), p.220-231 |
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| creator | Jones, A.P. D'Vaz, N. Meldrum, S. Palmer, D.J. Zhang, G. Prescott, S.L. |
| description | Summary
Background
Vitamin D (25[OH]D3) status in early life has been linked to the risk of allergic disease in multiple observational studies. While immunomodulating properties are well recognized, there are few longitudinal studies of 25(OH)D3 status, immune function and allergic disease in infants.
Objective
To investigate 25(OH)D3 levels at birth [cord blood (CB)] and at 6 months of age in relation to immune function at 6 months of age, and clinical outcomes up to 30 months of age in infants with a maternal history of atopy.
Methods
In a subset of infants (n = 225) enrolled in a RCT (ACTRN12606000281594), 25(OH)D3 levels were assessed in relation to peripheral blood mononuclear cell cytokine responses to house dust mite (HDM), ovalbumin (OVA) and β‐lactoglobulin allergens, or Toll‐like receptor (TLR) ligands (lipopolysaccharide, lipoteichoic acid, polyinosinic : polycytidylic acid and CpG oligonucleotide) at 6 months of age, in addition to clinical outcomes (eczema, wheeze and allergen sensitisation) up to 30 months of age.
Results
Infants with higher 25(OH)D3 at birth (≥ 75 nmol/L, compared with |
| doi_str_mv | 10.1111/cea.12449 |
| format | Article |
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Background
Vitamin D (25[OH]D3) status in early life has been linked to the risk of allergic disease in multiple observational studies. While immunomodulating properties are well recognized, there are few longitudinal studies of 25(OH)D3 status, immune function and allergic disease in infants.
Objective
To investigate 25(OH)D3 levels at birth [cord blood (CB)] and at 6 months of age in relation to immune function at 6 months of age, and clinical outcomes up to 30 months of age in infants with a maternal history of atopy.
Methods
In a subset of infants (n = 225) enrolled in a RCT (ACTRN12606000281594), 25(OH)D3 levels were assessed in relation to peripheral blood mononuclear cell cytokine responses to house dust mite (HDM), ovalbumin (OVA) and β‐lactoglobulin allergens, or Toll‐like receptor (TLR) ligands (lipopolysaccharide, lipoteichoic acid, polyinosinic : polycytidylic acid and CpG oligonucleotide) at 6 months of age, in addition to clinical outcomes (eczema, wheeze and allergen sensitisation) up to 30 months of age.
Results
Infants with higher 25(OH)D3 at birth (≥ 75 nmol/L, compared with < 50 nmol/L) had lower IL‐5 and IL‐13 responses to HDM by 6 months (P < 0.001 and P = 0.003, respectively). This was also reflected in strong inverse correlations between CB 25(OH)D3 levels and HDM IL‐13 (ρ = −0.57; P = 0.0002) and IL‐5 (ρ = −0.59, P = 0.0001) responses, with a similar trend for IL‐5 (ρ = −0.29; P = 0.009) responses to OVA. For innate stimulations, higher 25(OH)D3 levels at 6 months were associated with greater responses to TLR ligands. Additionally, higher CB 25(OH)D3 was associated with reduced risk eczema at 6 months (P = 0.011) and 12 months (P = 0.034).
Conclusion
This suggests that improving 25(OH)D3 status in pregnancy or early infancy may reduce the development of allergic disease in high‐risk infants by inhibiting cytokine profiles associated with allergy. Results of clinical trials are awaited to determine the efficacy of vitamin D supplementation in allergy prevention.</description><identifier>ISSN: 0954-7894</identifier><identifier>EISSN: 1365-2222</identifier><identifier>DOI: 10.1111/cea.12449</identifier><identifier>PMID: 25378203</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>25(OH)D3 ; Adaptive Immunity - physiology ; Adult ; Age ; allergens ; Allergens - immunology ; Allergens - pharmacology ; allergic disease ; Allergies ; Calcifediol - blood ; Calcifediol - immunology ; Child, Preschool ; cord blood ; cytokines ; Cytokines - blood ; Cytokines - immunology ; Dermatophagoides pteronyssinus ; eczema ; Female ; Humans ; Hypersensitivity - blood ; Hypersensitivity - immunology ; Immune system ; Immunity, Innate - physiology ; Infant ; Ligands ; Male ; Pregnancy - blood ; Pregnancy - immunology ; Risk Factors ; Toll-like receptor ; Vitamin D</subject><ispartof>Clinical and experimental allergy, 2015-01, Vol.45 (1), p.220-231</ispartof><rights>2014 John Wiley & Sons Ltd</rights><rights>2014 John Wiley & Sons Ltd.</rights><rights>Copyright © 2014 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4249-ebe63b3c5489dbbc83fc87db101b115e865f39e5d7f55df1fa7b8a0944b7c8ff3</citedby><cites>FETCH-LOGICAL-c4249-ebe63b3c5489dbbc83fc87db101b115e865f39e5d7f55df1fa7b8a0944b7c8ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcea.12449$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcea.12449$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25378203$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jones, A.P.</creatorcontrib><creatorcontrib>D'Vaz, N.</creatorcontrib><creatorcontrib>Meldrum, S.</creatorcontrib><creatorcontrib>Palmer, D.J.</creatorcontrib><creatorcontrib>Zhang, G.</creatorcontrib><creatorcontrib>Prescott, S.L.</creatorcontrib><title>25-hydroxyvitamin D3 status is associated with developing adaptive and innate immune responses in the first 6 months of life</title><title>Clinical and experimental allergy</title><addtitle>Clin Exp Allergy</addtitle><description>Summary
Background
Vitamin D (25[OH]D3) status in early life has been linked to the risk of allergic disease in multiple observational studies. While immunomodulating properties are well recognized, there are few longitudinal studies of 25(OH)D3 status, immune function and allergic disease in infants.
Objective
To investigate 25(OH)D3 levels at birth [cord blood (CB)] and at 6 months of age in relation to immune function at 6 months of age, and clinical outcomes up to 30 months of age in infants with a maternal history of atopy.
Methods
In a subset of infants (n = 225) enrolled in a RCT (ACTRN12606000281594), 25(OH)D3 levels were assessed in relation to peripheral blood mononuclear cell cytokine responses to house dust mite (HDM), ovalbumin (OVA) and β‐lactoglobulin allergens, or Toll‐like receptor (TLR) ligands (lipopolysaccharide, lipoteichoic acid, polyinosinic : polycytidylic acid and CpG oligonucleotide) at 6 months of age, in addition to clinical outcomes (eczema, wheeze and allergen sensitisation) up to 30 months of age.
Results
Infants with higher 25(OH)D3 at birth (≥ 75 nmol/L, compared with < 50 nmol/L) had lower IL‐5 and IL‐13 responses to HDM by 6 months (P < 0.001 and P = 0.003, respectively). This was also reflected in strong inverse correlations between CB 25(OH)D3 levels and HDM IL‐13 (ρ = −0.57; P = 0.0002) and IL‐5 (ρ = −0.59, P = 0.0001) responses, with a similar trend for IL‐5 (ρ = −0.29; P = 0.009) responses to OVA. For innate stimulations, higher 25(OH)D3 levels at 6 months were associated with greater responses to TLR ligands. Additionally, higher CB 25(OH)D3 was associated with reduced risk eczema at 6 months (P = 0.011) and 12 months (P = 0.034).
Conclusion
This suggests that improving 25(OH)D3 status in pregnancy or early infancy may reduce the development of allergic disease in high‐risk infants by inhibiting cytokine profiles associated with allergy. Results of clinical trials are awaited to determine the efficacy of vitamin D supplementation in allergy prevention.</description><subject>25(OH)D3</subject><subject>Adaptive Immunity - physiology</subject><subject>Adult</subject><subject>Age</subject><subject>allergens</subject><subject>Allergens - immunology</subject><subject>Allergens - pharmacology</subject><subject>allergic disease</subject><subject>Allergies</subject><subject>Calcifediol - blood</subject><subject>Calcifediol - immunology</subject><subject>Child, Preschool</subject><subject>cord blood</subject><subject>cytokines</subject><subject>Cytokines - blood</subject><subject>Cytokines - immunology</subject><subject>Dermatophagoides pteronyssinus</subject><subject>eczema</subject><subject>Female</subject><subject>Humans</subject><subject>Hypersensitivity - blood</subject><subject>Hypersensitivity - immunology</subject><subject>Immune system</subject><subject>Immunity, Innate - physiology</subject><subject>Infant</subject><subject>Ligands</subject><subject>Male</subject><subject>Pregnancy - blood</subject><subject>Pregnancy - immunology</subject><subject>Risk Factors</subject><subject>Toll-like receptor</subject><subject>Vitamin D</subject><issn>0954-7894</issn><issn>1365-2222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0c9u1DAQBvAIgehSOPACyBIXOKS14zi2j9XSLkgVXPh3s5x4zLok9tZ2tt0D78Kz8GS4bNsDEhJzmctvPmn0VdVzgo9ImeMB9BFp2lY-qBaEdqxuyjysFliytuZCtgfVk5QuMMaUSfG4OmgY5aLBdFH9aFi93pkYrndbl_XkPHpDUco6zwm5hHRKYXA6g0FXLq-RgS2MYeP8N6SN3mS3BaS9Qc77gpCbptkDipA2wScoER7lNSDrYsqo-_VzCj6vEwoWjc7C0-qR1WOCZ7f7sPp0dvpx-bY-_7B6tzw5r4e2aWUNPXS0pwNrhTR9PwhqB8FNTzDpCWEgOmapBGa4ZcxYYjXvhcaybXs-CGvpYfVqn7uJ4XKGlNXk0gDjqD2EOSnStRwTyQX_H0qIlKQRhb78i16EOfryyI3CjPCGdkW93qshhpQiWLWJbtJxpwhWN_WpUp_6U1-xL24T534Ccy_v-irgeA-u3Ai7fyep5enJXWS9v3Apw_X9hY7fVccpZ-rL-5XCXJ59XX5eKUp_AwpHtEE</recordid><startdate>201501</startdate><enddate>201501</enddate><creator>Jones, A.P.</creator><creator>D'Vaz, N.</creator><creator>Meldrum, S.</creator><creator>Palmer, D.J.</creator><creator>Zhang, G.</creator><creator>Prescott, S.L.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201501</creationdate><title>25-hydroxyvitamin D3 status is associated with developing adaptive and innate immune responses in the first 6 months of life</title><author>Jones, A.P. ; D'Vaz, N. ; Meldrum, S. ; Palmer, D.J. ; Zhang, G. ; Prescott, S.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4249-ebe63b3c5489dbbc83fc87db101b115e865f39e5d7f55df1fa7b8a0944b7c8ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>25(OH)D3</topic><topic>Adaptive Immunity - physiology</topic><topic>Adult</topic><topic>Age</topic><topic>allergens</topic><topic>Allergens - immunology</topic><topic>Allergens - pharmacology</topic><topic>allergic disease</topic><topic>Allergies</topic><topic>Calcifediol - blood</topic><topic>Calcifediol - immunology</topic><topic>Child, Preschool</topic><topic>cord blood</topic><topic>cytokines</topic><topic>Cytokines - blood</topic><topic>Cytokines - immunology</topic><topic>Dermatophagoides pteronyssinus</topic><topic>eczema</topic><topic>Female</topic><topic>Humans</topic><topic>Hypersensitivity - blood</topic><topic>Hypersensitivity - immunology</topic><topic>Immune system</topic><topic>Immunity, Innate - physiology</topic><topic>Infant</topic><topic>Ligands</topic><topic>Male</topic><topic>Pregnancy - blood</topic><topic>Pregnancy - immunology</topic><topic>Risk Factors</topic><topic>Toll-like receptor</topic><topic>Vitamin D</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jones, A.P.</creatorcontrib><creatorcontrib>D'Vaz, N.</creatorcontrib><creatorcontrib>Meldrum, S.</creatorcontrib><creatorcontrib>Palmer, D.J.</creatorcontrib><creatorcontrib>Zhang, G.</creatorcontrib><creatorcontrib>Prescott, S.L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jones, A.P.</au><au>D'Vaz, N.</au><au>Meldrum, S.</au><au>Palmer, D.J.</au><au>Zhang, G.</au><au>Prescott, S.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>25-hydroxyvitamin D3 status is associated with developing adaptive and innate immune responses in the first 6 months of life</atitle><jtitle>Clinical and experimental allergy</jtitle><addtitle>Clin Exp Allergy</addtitle><date>2015-01</date><risdate>2015</risdate><volume>45</volume><issue>1</issue><spage>220</spage><epage>231</epage><pages>220-231</pages><issn>0954-7894</issn><eissn>1365-2222</eissn><abstract>Summary
Background
Vitamin D (25[OH]D3) status in early life has been linked to the risk of allergic disease in multiple observational studies. While immunomodulating properties are well recognized, there are few longitudinal studies of 25(OH)D3 status, immune function and allergic disease in infants.
Objective
To investigate 25(OH)D3 levels at birth [cord blood (CB)] and at 6 months of age in relation to immune function at 6 months of age, and clinical outcomes up to 30 months of age in infants with a maternal history of atopy.
Methods
In a subset of infants (n = 225) enrolled in a RCT (ACTRN12606000281594), 25(OH)D3 levels were assessed in relation to peripheral blood mononuclear cell cytokine responses to house dust mite (HDM), ovalbumin (OVA) and β‐lactoglobulin allergens, or Toll‐like receptor (TLR) ligands (lipopolysaccharide, lipoteichoic acid, polyinosinic : polycytidylic acid and CpG oligonucleotide) at 6 months of age, in addition to clinical outcomes (eczema, wheeze and allergen sensitisation) up to 30 months of age.
Results
Infants with higher 25(OH)D3 at birth (≥ 75 nmol/L, compared with < 50 nmol/L) had lower IL‐5 and IL‐13 responses to HDM by 6 months (P < 0.001 and P = 0.003, respectively). This was also reflected in strong inverse correlations between CB 25(OH)D3 levels and HDM IL‐13 (ρ = −0.57; P = 0.0002) and IL‐5 (ρ = −0.59, P = 0.0001) responses, with a similar trend for IL‐5 (ρ = −0.29; P = 0.009) responses to OVA. For innate stimulations, higher 25(OH)D3 levels at 6 months were associated with greater responses to TLR ligands. Additionally, higher CB 25(OH)D3 was associated with reduced risk eczema at 6 months (P = 0.011) and 12 months (P = 0.034).
Conclusion
This suggests that improving 25(OH)D3 status in pregnancy or early infancy may reduce the development of allergic disease in high‐risk infants by inhibiting cytokine profiles associated with allergy. Results of clinical trials are awaited to determine the efficacy of vitamin D supplementation in allergy prevention.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>25378203</pmid><doi>10.1111/cea.12449</doi><tpages>12</tpages></addata></record> |
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| identifier | ISSN: 0954-7894 |
| ispartof | Clinical and experimental allergy, 2015-01, Vol.45 (1), p.220-231 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | 25(OH)D3 Adaptive Immunity - physiology Adult Age allergens Allergens - immunology Allergens - pharmacology allergic disease Allergies Calcifediol - blood Calcifediol - immunology Child, Preschool cord blood cytokines Cytokines - blood Cytokines - immunology Dermatophagoides pteronyssinus eczema Female Humans Hypersensitivity - blood Hypersensitivity - immunology Immune system Immunity, Innate - physiology Infant Ligands Male Pregnancy - blood Pregnancy - immunology Risk Factors Toll-like receptor Vitamin D |
| title | 25-hydroxyvitamin D3 status is associated with developing adaptive and innate immune responses in the first 6 months of life |
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