Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity

The key role of APP in the pathogenesis of Alzheimer disease is well established. However, postnatal lethality of double knockout mice has so far precluded the analysis of the physiological functions of APP and the APLPs in the brain. Previously, APP family proteins have been implicated in synaptic...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Acta neuropathologica 2015-01, Vol.129 (1), p.21-37
Hauptverfasser:	Hick, Meike, Herrmann, Ulrike, Weyer, Sascha W., Mallm, Jan-Philipp, Tschäpe, Jakob-Andreas, Borgers, Marianne, Mercken, Marc, Roth, Fabian C., Draguhn, Andreas, Slomianka, Lutz, Wolfer, David P., Korte, Martin, Müller, Ulrike C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Animals Dendrites - pathology Dendrites - physiology Female Hippocampus - pathology Hippocampus - physiopathology Male Maze Learning - physiology Medicine Medicine & Public Health Mice, Knockout Motor Activity - physiology Neurites - pathology Neurites - physiology Neuronal Plasticity - physiology Neurosciences Original Paper Pathology Peptide Fragments - genetics Peptide Fragments - metabolism Recombinant Proteins - metabolism Spatial Memory - physiology Synapses - pathology Synapses - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!