Using zebrafish to uncover the genetic and neural basis of aggression, a frequent comorbid symptom of psychiatric disorders
Aggression is an important adaptive behavior that can be used to monopolize resources such as mates or food, acquire and defend territory and establish dominant hierarchies in social groups. It is also a symptom of several psychiatric disorders including attention-deficit/hyperactivity disorder and...
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| Veröffentlicht in: | Behavioural brain research 2015-01, Vol.276, p.171-180 |
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| container_title | Behavioural brain research |
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| creator | Jones, Lauren J Norton, William H J |
| description | Aggression is an important adaptive behavior that can be used to monopolize resources such as mates or food, acquire and defend territory and establish dominant hierarchies in social groups. It is also a symptom of several psychiatric disorders including attention-deficit/hyperactivity disorder and schizophrenia. The frequent comorbidity of aggression and psychiatric diseases suggests that common genes and neural circuits may link these disorders. Research using animal models has the potential to uncover these genes and neural circuits despite the difficulty of fully modeling human behavioral disorders. In this review we propose that zebrafish may be a suitable model organism for aggression research with the potential to shed light upon the aggressive symptoms of human diseases. |
| doi_str_mv | 10.1016/j.bbr.2014.05.055 |
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In this review we propose that zebrafish may be a suitable model organism for aggression research with the potential to shed light upon the aggressive symptoms of human diseases.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/j.bbr.2014.05.055</identifier><identifier>PMID: 24954772</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Aggression - physiology ; Animals ; Attention Deficit Disorder with Hyperactivity - genetics ; Attention Deficit Disorder with Hyperactivity - metabolism ; Attention Deficit Disorder with Hyperactivity - psychology ; Danio rerio ; Humans ; Models, Animal ; Neurotransmitter Agents - genetics ; Neurotransmitter Agents - metabolism ; Schizophrenia - genetics ; Schizophrenia - metabolism ; Schizophrenic Psychology ; Zebrafish - genetics ; Zebrafish - physiology</subject><ispartof>Behavioural brain research, 2015-01, Vol.276, p.171-180</ispartof><rights>Copyright © 2014 Elsevier B.V. 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In this review we propose that zebrafish may be a suitable model organism for aggression research with the potential to shed light upon the aggressive symptoms of human diseases.</description><subject>Aggression - physiology</subject><subject>Animals</subject><subject>Attention Deficit Disorder with Hyperactivity - genetics</subject><subject>Attention Deficit Disorder with Hyperactivity - metabolism</subject><subject>Attention Deficit Disorder with Hyperactivity - psychology</subject><subject>Danio rerio</subject><subject>Humans</subject><subject>Models, Animal</subject><subject>Neurotransmitter Agents - genetics</subject><subject>Neurotransmitter Agents - metabolism</subject><subject>Schizophrenia - genetics</subject><subject>Schizophrenia - metabolism</subject><subject>Schizophrenic Psychology</subject><subject>Zebrafish - genetics</subject><subject>Zebrafish - physiology</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUuLFDEQgIMo7uzqD_AiOXqwxzw76aMsvmDBi3sOeVRmMkx3xlS3MPrn7WFXzwsFdfnqo-Aj5A1nW854_-GwDaFtBeNqy_Q6-hnZcGtEZ7QanpPNyvSdksJekWvEA2NMMc1fkiuhBq2MERvy5x7LtKO_ITSfC-7pXOkyxfoLGp33QHcwwVwi9VOiEyzNH2nwWJDWTP1u1wCx1Ok99TQ3-LnANNNYx9pCSRTP42mu4wU94Tnui5_bqkoFa0vQ8BV5kf0R4fXjviH3nz_9uP3a3X3_8u32410XlZRzp3g2xvBguZAAvUlRWZljThBDyDz5OIReppSsliYM2tg4WCtMMoYFFbS8Ie8evKdW1xdxdmPBCMejn6Au6HivDONWs6egYhj0wHqxovwBja0iNsju1Mro29lx5i553MGtedwlj2N6nYv-7aN-CSOk_xf_esi_iDmOfQ</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Jones, Lauren J</creator><creator>Norton, William H J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QG</scope><scope>7TK</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>L.G</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20150101</creationdate><title>Using zebrafish to uncover the genetic and neural basis of aggression, a frequent comorbid symptom of psychiatric disorders</title><author>Jones, Lauren J ; 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| identifier | ISSN: 0166-4328 |
| ispartof | Behavioural brain research, 2015-01, Vol.276, p.171-180 |
| issn | 0166-4328 1872-7549 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Aggression - physiology Animals Attention Deficit Disorder with Hyperactivity - genetics Attention Deficit Disorder with Hyperactivity - metabolism Attention Deficit Disorder with Hyperactivity - psychology Danio rerio Humans Models, Animal Neurotransmitter Agents - genetics Neurotransmitter Agents - metabolism Schizophrenia - genetics Schizophrenia - metabolism Schizophrenic Psychology Zebrafish - genetics Zebrafish - physiology |
| title | Using zebrafish to uncover the genetic and neural basis of aggression, a frequent comorbid symptom of psychiatric disorders |
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