Standard of hygiene and immune adaptation in newborn infants
Abstract The prevalence of immune-mediated diseases, such as allergies and type 1 diabetes, is on the rise in the developed world. In order to explore differences in the gene expression patterns induced in utero in infants born in contrasting standards of living and hygiene, we collected umbilical c...
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| Veröffentlicht in: | Clinical immunology (Orlando, Fla.) Fla.), 2014-11, Vol.155 (1), p.136-147 |
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| creator | Kallionpää, Henna Laajala, Essi Öling, Viveka Härkönen, Taina Tillmann, Vallo Dorshakova, Natalya V Ilonen, Jorma Lähdesmäki, Harri Knip, Mikael Lahesmaa, Riitta |
| description | Abstract The prevalence of immune-mediated diseases, such as allergies and type 1 diabetes, is on the rise in the developed world. In order to explore differences in the gene expression patterns induced in utero in infants born in contrasting standards of living and hygiene, we collected umbilical cord blood RNA samples from infants born in Finland (modern society), Estonia (rapidly developing society) and the Republic of Karelia, Russia (poor economic conditions). The whole blood transcriptome of Finnish and Estonian neonates differed from their Karelian counterparts, suggesting exposure to toll-like receptor (TLR) ligands and a more matured immune response in infants born in Karelia. These results further support the concept of a conspicuous plasticity in the developing immune system: the environmental factors that play a role in the susceptibility/protection towards immune-mediated diseases begin to shape the neonatal immunity already in utero and direct the maturation in accordance with the surrounding microbial milieu. |
| doi_str_mv | 10.1016/j.clim.2014.09.009 |
| format | Article |
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In order to explore differences in the gene expression patterns induced in utero in infants born in contrasting standards of living and hygiene, we collected umbilical cord blood RNA samples from infants born in Finland (modern society), Estonia (rapidly developing society) and the Republic of Karelia, Russia (poor economic conditions). The whole blood transcriptome of Finnish and Estonian neonates differed from their Karelian counterparts, suggesting exposure to toll-like receptor (TLR) ligands and a more matured immune response in infants born in Karelia. These results further support the concept of a conspicuous plasticity in the developing immune system: the environmental factors that play a role in the susceptibility/protection towards immune-mediated diseases begin to shape the neonatal immunity already in utero and direct the maturation in accordance with the surrounding microbial milieu.</description><identifier>ISSN: 1521-6616</identifier><identifier>EISSN: 1521-7035</identifier><identifier>DOI: 10.1016/j.clim.2014.09.009</identifier><identifier>PMID: 25245264</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Allergy and Immunology ; Cord blood ; Estonia ; Female ; Fetal Blood - metabolism ; Finland ; Gene expression ; Gene Expression Regulation - immunology ; Genotype ; HLA-DR3 Antigen - genetics ; HLA-DR3 Antigen - metabolism ; HLA-DR4 Antigen - genetics ; HLA-DR4 Antigen - metabolism ; Humans ; Hygiene ; Hygiene hypothesis ; Hypersensitivity - immunology ; Immune adaptation ; Infant, Newborn ; Innate immunity ; Male ; Newborn infant ; Oligonucleotide Array Sequence Analysis ; RNA - genetics ; RNA - metabolism ; Russia ; Signal Transduction ; Socioeconomic Factors ; Transcriptome</subject><ispartof>Clinical immunology (Orlando, Fla.), 2014-11, Vol.155 (1), p.136-147</ispartof><rights>2014</rights><rights>Copyright © 2014. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-2bbabfebf86f34b3c770aaabc08c3724c4432150d3e208fb6a80ce25a1b6ef0a3</citedby><cites>FETCH-LOGICAL-c488t-2bbabfebf86f34b3c770aaabc08c3724c4432150d3e208fb6a80ce25a1b6ef0a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clim.2014.09.009$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25245264$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kallionpää, Henna</creatorcontrib><creatorcontrib>Laajala, Essi</creatorcontrib><creatorcontrib>Öling, Viveka</creatorcontrib><creatorcontrib>Härkönen, Taina</creatorcontrib><creatorcontrib>Tillmann, Vallo</creatorcontrib><creatorcontrib>Dorshakova, Natalya V</creatorcontrib><creatorcontrib>Ilonen, Jorma</creatorcontrib><creatorcontrib>Lähdesmäki, Harri</creatorcontrib><creatorcontrib>Knip, Mikael</creatorcontrib><creatorcontrib>Lahesmaa, Riitta</creatorcontrib><creatorcontrib>DIABIMMUNE Study Group</creatorcontrib><title>Standard of hygiene and immune adaptation in newborn infants</title><title>Clinical immunology (Orlando, Fla.)</title><addtitle>Clin Immunol</addtitle><description>Abstract The prevalence of immune-mediated diseases, such as allergies and type 1 diabetes, is on the rise in the developed world. In order to explore differences in the gene expression patterns induced in utero in infants born in contrasting standards of living and hygiene, we collected umbilical cord blood RNA samples from infants born in Finland (modern society), Estonia (rapidly developing society) and the Republic of Karelia, Russia (poor economic conditions). The whole blood transcriptome of Finnish and Estonian neonates differed from their Karelian counterparts, suggesting exposure to toll-like receptor (TLR) ligands and a more matured immune response in infants born in Karelia. These results further support the concept of a conspicuous plasticity in the developing immune system: the environmental factors that play a role in the susceptibility/protection towards immune-mediated diseases begin to shape the neonatal immunity already in utero and direct the maturation in accordance with the surrounding microbial milieu.</description><subject>Allergy and Immunology</subject><subject>Cord blood</subject><subject>Estonia</subject><subject>Female</subject><subject>Fetal Blood - metabolism</subject><subject>Finland</subject><subject>Gene expression</subject><subject>Gene Expression Regulation - immunology</subject><subject>Genotype</subject><subject>HLA-DR3 Antigen - genetics</subject><subject>HLA-DR3 Antigen - metabolism</subject><subject>HLA-DR4 Antigen - genetics</subject><subject>HLA-DR4 Antigen - metabolism</subject><subject>Humans</subject><subject>Hygiene</subject><subject>Hygiene hypothesis</subject><subject>Hypersensitivity - immunology</subject><subject>Immune adaptation</subject><subject>Infant, Newborn</subject><subject>Innate immunity</subject><subject>Male</subject><subject>Newborn infant</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>RNA - genetics</subject><subject>RNA - metabolism</subject><subject>Russia</subject><subject>Signal Transduction</subject><subject>Socioeconomic Factors</subject><subject>Transcriptome</subject><issn>1521-6616</issn><issn>1521-7035</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU2L1TAUhoMozjj6B1xIl25uPTlJ0xYGQQa_YMDF6Dok6Ynm2qbXpB25_96Ue3XhQlzlJTzvu3gOY8851By4erWv3RimGoHLGvoaoH_ALnmDfNeCaB6es1JcXbAnOe8BoEFUj9kFNigbVPKSXd8tJg4mDdXsq2_Hr4EiVeWnCtO0bnEwh8UsYY5ViFWkn3ZOW_QmLvkpe-TNmOnZ-b1iX969_XzzYXf76f3Hmze3Oye7btmhtcZ6sr5TXkgrXNuCMcY66JxoUTopBfIGBkEInbfKdOAIG8OtIg9GXLGXp91Dmn-slBc9hexoHE2kec2aK9kC77Dt_wPFvldcqKageEJdmnNO5PUhhcmko-agN8F6rzfBehOsoddFcCm9OO-vdqLhT-W30QJcnwAqQu4DJZ1dkepoCIncooc5_Hv_9V_1gsTgzPidjpT385piUa25zqhB320n3i7MJQAiSPELYr6gfg</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Kallionpää, Henna</creator><creator>Laajala, Essi</creator><creator>Öling, Viveka</creator><creator>Härkönen, Taina</creator><creator>Tillmann, Vallo</creator><creator>Dorshakova, Natalya V</creator><creator>Ilonen, Jorma</creator><creator>Lähdesmäki, Harri</creator><creator>Knip, Mikael</creator><creator>Lahesmaa, Riitta</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20141101</creationdate><title>Standard of hygiene and immune adaptation in newborn infants</title><author>Kallionpää, Henna ; Laajala, Essi ; Öling, Viveka ; Härkönen, Taina ; Tillmann, Vallo ; Dorshakova, Natalya V ; Ilonen, Jorma ; Lähdesmäki, Harri ; Knip, Mikael ; Lahesmaa, Riitta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-2bbabfebf86f34b3c770aaabc08c3724c4432150d3e208fb6a80ce25a1b6ef0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Allergy and Immunology</topic><topic>Cord blood</topic><topic>Estonia</topic><topic>Female</topic><topic>Fetal Blood - metabolism</topic><topic>Finland</topic><topic>Gene expression</topic><topic>Gene Expression Regulation - immunology</topic><topic>Genotype</topic><topic>HLA-DR3 Antigen - genetics</topic><topic>HLA-DR3 Antigen - metabolism</topic><topic>HLA-DR4 Antigen - genetics</topic><topic>HLA-DR4 Antigen - metabolism</topic><topic>Humans</topic><topic>Hygiene</topic><topic>Hygiene hypothesis</topic><topic>Hypersensitivity - immunology</topic><topic>Immune adaptation</topic><topic>Infant, Newborn</topic><topic>Innate immunity</topic><topic>Male</topic><topic>Newborn infant</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>RNA - genetics</topic><topic>RNA - metabolism</topic><topic>Russia</topic><topic>Signal Transduction</topic><topic>Socioeconomic Factors</topic><topic>Transcriptome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kallionpää, Henna</creatorcontrib><creatorcontrib>Laajala, Essi</creatorcontrib><creatorcontrib>Öling, Viveka</creatorcontrib><creatorcontrib>Härkönen, Taina</creatorcontrib><creatorcontrib>Tillmann, Vallo</creatorcontrib><creatorcontrib>Dorshakova, Natalya V</creatorcontrib><creatorcontrib>Ilonen, Jorma</creatorcontrib><creatorcontrib>Lähdesmäki, Harri</creatorcontrib><creatorcontrib>Knip, Mikael</creatorcontrib><creatorcontrib>Lahesmaa, Riitta</creatorcontrib><creatorcontrib>DIABIMMUNE Study Group</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Clinical immunology (Orlando, Fla.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kallionpää, Henna</au><au>Laajala, Essi</au><au>Öling, Viveka</au><au>Härkönen, Taina</au><au>Tillmann, Vallo</au><au>Dorshakova, Natalya V</au><au>Ilonen, Jorma</au><au>Lähdesmäki, Harri</au><au>Knip, Mikael</au><au>Lahesmaa, Riitta</au><aucorp>DIABIMMUNE Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Standard of hygiene and immune adaptation in newborn infants</atitle><jtitle>Clinical immunology (Orlando, Fla.)</jtitle><addtitle>Clin Immunol</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>155</volume><issue>1</issue><spage>136</spage><epage>147</epage><pages>136-147</pages><issn>1521-6616</issn><eissn>1521-7035</eissn><abstract>Abstract The prevalence of immune-mediated diseases, such as allergies and type 1 diabetes, is on the rise in the developed world. 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| subjects | Allergy and Immunology Cord blood Estonia Female Fetal Blood - metabolism Finland Gene expression Gene Expression Regulation - immunology Genotype HLA-DR3 Antigen - genetics HLA-DR3 Antigen - metabolism HLA-DR4 Antigen - genetics HLA-DR4 Antigen - metabolism Humans Hygiene Hygiene hypothesis Hypersensitivity - immunology Immune adaptation Infant, Newborn Innate immunity Male Newborn infant Oligonucleotide Array Sequence Analysis RNA - genetics RNA - metabolism Russia Signal Transduction Socioeconomic Factors Transcriptome |
| title | Standard of hygiene and immune adaptation in newborn infants |
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