Effects of adverse life events on heart rate variability, cortisol, and C-reactive protein
Objective Our objective was to assess whether self‐reported adverse life events during childhood or over the lifespan are associated with altered activity of the autonomic nervous system (ANS), the hypothalamic‐pituitary‐adrenal axis (HPA axis), and the immune system. Method This study was performed...
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| Veröffentlicht in: | Acta psychiatrica Scandinavica 2015-01, Vol.131 (1), p.40-50 |
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| creator | van Ockenburg, S. L. Tak, L. M. Bakker, S. J. L. Gans, R. O. B. de Jonge, P. Rosmalen, J. G. M. |
| description | Objective
Our objective was to assess whether self‐reported adverse life events during childhood or over the lifespan are associated with altered activity of the autonomic nervous system (ANS), the hypothalamic‐pituitary‐adrenal axis (HPA axis), and the immune system.
Method
This study was performed in a population‐based cohort of 1094 adults aged 33–79 years, 46.3% male, average age 53 (SD 11.4). Two waves of data were collected at a 2‐year interval, enabling replication of the analyses. Cumulative exposure to adverse life events was assessed by means of the List of Threatening Experiences. ANS function was assessed by spectral analysis of heart rate variability in the high‐frequency band (HRV‐HF). HPA axis function was assessed by 24‐h urinary free cortisol (24‐h UFC) excretion. Inflammation was assessed by high‐sensitive C‐reactive protein (hsCRP).
Results
Multiple linear regression analyses did not reveal any significant associations, with the exception of one significant negative association between the lifetime score of adverse life events and HRV‐HF β = −0.028; P = 0.037 at baseline, but not at follow up 2 years later.
Conclusion
In a large population‐based cohort, adverse life events were not consistently associated with HRV‐HF, 24‐h UFC or (hsCRP). |
| doi_str_mv | 10.1111/acps.12286 |
| format | Article |
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Our objective was to assess whether self‐reported adverse life events during childhood or over the lifespan are associated with altered activity of the autonomic nervous system (ANS), the hypothalamic‐pituitary‐adrenal axis (HPA axis), and the immune system.
Method
This study was performed in a population‐based cohort of 1094 adults aged 33–79 years, 46.3% male, average age 53 (SD 11.4). Two waves of data were collected at a 2‐year interval, enabling replication of the analyses. Cumulative exposure to adverse life events was assessed by means of the List of Threatening Experiences. ANS function was assessed by spectral analysis of heart rate variability in the high‐frequency band (HRV‐HF). HPA axis function was assessed by 24‐h urinary free cortisol (24‐h UFC) excretion. Inflammation was assessed by high‐sensitive C‐reactive protein (hsCRP).
Results
Multiple linear regression analyses did not reveal any significant associations, with the exception of one significant negative association between the lifetime score of adverse life events and HRV‐HF β = −0.028; P = 0.037 at baseline, but not at follow up 2 years later.
Conclusion
In a large population‐based cohort, adverse life events were not consistently associated with HRV‐HF, 24‐h UFC or (hsCRP).</description><identifier>ISSN: 0001-690X</identifier><identifier>EISSN: 1600-0447</identifier><identifier>DOI: 10.1111/acps.12286</identifier><identifier>PMID: 24833194</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; autonomic nervous system ; C-reactive protein ; C-Reactive Protein - metabolism ; Chromatography, Liquid - methods ; Cohort Studies ; Cortisol ; Female ; Heart Rate ; heart rate variability ; Hormones ; Humans ; Hydrocortisone - urine ; hypothalamic-pituitary-adrenal axis ; Hypothalamo-Hypophyseal System - metabolism ; Immune system ; Life Change Events ; Male ; Mass Spectrometry - methods ; Middle Aged ; Netherlands ; Neuropsychology ; Pituitary-Adrenal System - metabolism ; Proteins ; Psychiatry ; psychosocial stress ; Retrospective Studies ; Stress, Psychological - blood ; Stress, Psychological - psychology ; Stress, Psychological - urine ; Surveys and Questionnaires</subject><ispartof>Acta psychiatrica Scandinavica, 2015-01, Vol.131 (1), p.40-50</ispartof><rights>2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>2015 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4986-3e75a7b4a47ab654c97ae0b262ea9328dab67c7fddc8637b57000d153c8630333</citedby><cites>FETCH-LOGICAL-c4986-3e75a7b4a47ab654c97ae0b262ea9328dab67c7fddc8637b57000d153c8630333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Facps.12286$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Facps.12286$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24833194$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Ockenburg, S. L.</creatorcontrib><creatorcontrib>Tak, L. M.</creatorcontrib><creatorcontrib>Bakker, S. J. L.</creatorcontrib><creatorcontrib>Gans, R. O. B.</creatorcontrib><creatorcontrib>de Jonge, P.</creatorcontrib><creatorcontrib>Rosmalen, J. G. M.</creatorcontrib><title>Effects of adverse life events on heart rate variability, cortisol, and C-reactive protein</title><title>Acta psychiatrica Scandinavica</title><addtitle>Acta Psychiatr Scand</addtitle><description>Objective
Our objective was to assess whether self‐reported adverse life events during childhood or over the lifespan are associated with altered activity of the autonomic nervous system (ANS), the hypothalamic‐pituitary‐adrenal axis (HPA axis), and the immune system.
Method
This study was performed in a population‐based cohort of 1094 adults aged 33–79 years, 46.3% male, average age 53 (SD 11.4). Two waves of data were collected at a 2‐year interval, enabling replication of the analyses. Cumulative exposure to adverse life events was assessed by means of the List of Threatening Experiences. ANS function was assessed by spectral analysis of heart rate variability in the high‐frequency band (HRV‐HF). HPA axis function was assessed by 24‐h urinary free cortisol (24‐h UFC) excretion. Inflammation was assessed by high‐sensitive C‐reactive protein (hsCRP).
Results
Multiple linear regression analyses did not reveal any significant associations, with the exception of one significant negative association between the lifetime score of adverse life events and HRV‐HF β = −0.028; P = 0.037 at baseline, but not at follow up 2 years later.
Conclusion
In a large population‐based cohort, adverse life events were not consistently associated with HRV‐HF, 24‐h UFC or (hsCRP).</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>autonomic nervous system</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - metabolism</subject><subject>Chromatography, Liquid - methods</subject><subject>Cohort Studies</subject><subject>Cortisol</subject><subject>Female</subject><subject>Heart Rate</subject><subject>heart rate variability</subject><subject>Hormones</subject><subject>Humans</subject><subject>Hydrocortisone - urine</subject><subject>hypothalamic-pituitary-adrenal axis</subject><subject>Hypothalamo-Hypophyseal System - metabolism</subject><subject>Immune system</subject><subject>Life Change Events</subject><subject>Male</subject><subject>Mass Spectrometry - methods</subject><subject>Middle Aged</subject><subject>Netherlands</subject><subject>Neuropsychology</subject><subject>Pituitary-Adrenal System - metabolism</subject><subject>Proteins</subject><subject>Psychiatry</subject><subject>psychosocial stress</subject><subject>Retrospective Studies</subject><subject>Stress, Psychological - blood</subject><subject>Stress, Psychological - psychology</subject><subject>Stress, Psychological - urine</subject><subject>Surveys and Questionnaires</subject><issn>0001-690X</issn><issn>1600-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1P3DAQhq2qVdlCL_0ByFIvqCJgx46dHCGi9AP1QwUt6sWaOBNhmk0W27vt_vs6XeDQQ9W5jGb0zDt69RLyirMjnuoY7DIc8Twv1RMy44qxjEmpn5IZY4xnqmLXO-RFCLdpLDgrn5OdXJZC8ErOyPezrkMbAx07Cu0afUDauw4prnGY1gO9QfCReohI1-AdNK53cXNI7eijC2N_SGFoaZ15BBvdGunSjxHdsEeeddAHfHnfd8nV27PL-l128fn8fX1ykVlZlSoTqAvQjQSpoVGFtJUGZE2ucoRK5GWbttrqrm1tqYRuCp18tLwQ08iEELvkYKub_t6tMESzcMFi38OA4yoYrqRmXAsl_wMVulC51hP6-i_0dlz5IRmZKMWEKnKVqDdbyvoxBI-dWXq3AL8xnJkpHDOFY_6Ek-D9e8lVs8D2EX1IIwF8C_x0PW7-IWVO6i_fHkSz7Y0LEX893oD_YZRObsz807n5cP1xzr7Oa3MqfgNFeqcu</recordid><startdate>201501</startdate><enddate>201501</enddate><creator>van Ockenburg, S. L.</creator><creator>Tak, L. M.</creator><creator>Bakker, S. J. L.</creator><creator>Gans, R. O. B.</creator><creator>de Jonge, P.</creator><creator>Rosmalen, J. G. M.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201501</creationdate><title>Effects of adverse life events on heart rate variability, cortisol, and C-reactive protein</title><author>van Ockenburg, S. L. ; Tak, L. M. ; Bakker, S. J. L. ; Gans, R. O. B. ; de Jonge, P. ; Rosmalen, J. G. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4986-3e75a7b4a47ab654c97ae0b262ea9328dab67c7fddc8637b57000d153c8630333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>autonomic nervous system</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - metabolism</topic><topic>Chromatography, Liquid - methods</topic><topic>Cohort Studies</topic><topic>Cortisol</topic><topic>Female</topic><topic>Heart Rate</topic><topic>heart rate variability</topic><topic>Hormones</topic><topic>Humans</topic><topic>Hydrocortisone - urine</topic><topic>hypothalamic-pituitary-adrenal axis</topic><topic>Hypothalamo-Hypophyseal System - metabolism</topic><topic>Immune system</topic><topic>Life Change Events</topic><topic>Male</topic><topic>Mass Spectrometry - methods</topic><topic>Middle Aged</topic><topic>Netherlands</topic><topic>Neuropsychology</topic><topic>Pituitary-Adrenal System - metabolism</topic><topic>Proteins</topic><topic>Psychiatry</topic><topic>psychosocial stress</topic><topic>Retrospective Studies</topic><topic>Stress, Psychological - blood</topic><topic>Stress, Psychological - psychology</topic><topic>Stress, Psychological - urine</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Ockenburg, S. L.</creatorcontrib><creatorcontrib>Tak, L. M.</creatorcontrib><creatorcontrib>Bakker, S. J. L.</creatorcontrib><creatorcontrib>Gans, R. O. B.</creatorcontrib><creatorcontrib>de Jonge, P.</creatorcontrib><creatorcontrib>Rosmalen, J. G. M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Acta psychiatrica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Ockenburg, S. L.</au><au>Tak, L. M.</au><au>Bakker, S. J. L.</au><au>Gans, R. O. B.</au><au>de Jonge, P.</au><au>Rosmalen, J. G. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of adverse life events on heart rate variability, cortisol, and C-reactive protein</atitle><jtitle>Acta psychiatrica Scandinavica</jtitle><addtitle>Acta Psychiatr Scand</addtitle><date>2015-01</date><risdate>2015</risdate><volume>131</volume><issue>1</issue><spage>40</spage><epage>50</epage><pages>40-50</pages><issn>0001-690X</issn><eissn>1600-0447</eissn><abstract>Objective
Our objective was to assess whether self‐reported adverse life events during childhood or over the lifespan are associated with altered activity of the autonomic nervous system (ANS), the hypothalamic‐pituitary‐adrenal axis (HPA axis), and the immune system.
Method
This study was performed in a population‐based cohort of 1094 adults aged 33–79 years, 46.3% male, average age 53 (SD 11.4). Two waves of data were collected at a 2‐year interval, enabling replication of the analyses. Cumulative exposure to adverse life events was assessed by means of the List of Threatening Experiences. ANS function was assessed by spectral analysis of heart rate variability in the high‐frequency band (HRV‐HF). HPA axis function was assessed by 24‐h urinary free cortisol (24‐h UFC) excretion. Inflammation was assessed by high‐sensitive C‐reactive protein (hsCRP).
Results
Multiple linear regression analyses did not reveal any significant associations, with the exception of one significant negative association between the lifetime score of adverse life events and HRV‐HF β = −0.028; P = 0.037 at baseline, but not at follow up 2 years later.
Conclusion
In a large population‐based cohort, adverse life events were not consistently associated with HRV‐HF, 24‐h UFC or (hsCRP).</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24833194</pmid><doi>10.1111/acps.12286</doi><tpages>11</tpages></addata></record> |
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| ispartof | Acta psychiatrica Scandinavica, 2015-01, Vol.131 (1), p.40-50 |
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| subjects | Adult Age Factors Aged Aged, 80 and over autonomic nervous system C-reactive protein C-Reactive Protein - metabolism Chromatography, Liquid - methods Cohort Studies Cortisol Female Heart Rate heart rate variability Hormones Humans Hydrocortisone - urine hypothalamic-pituitary-adrenal axis Hypothalamo-Hypophyseal System - metabolism Immune system Life Change Events Male Mass Spectrometry - methods Middle Aged Netherlands Neuropsychology Pituitary-Adrenal System - metabolism Proteins Psychiatry psychosocial stress Retrospective Studies Stress, Psychological - blood Stress, Psychological - psychology Stress, Psychological - urine Surveys and Questionnaires |
| title | Effects of adverse life events on heart rate variability, cortisol, and C-reactive protein |
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