Pervasive Axonal Transport Deficits in Multiple Sclerosis Models

Impaired axonal transport can contribute to axon degeneration and has been described in many neurodegenerative diseases. Multiple sclerosis (MS) is a common neuroinflammatory disease, which is characterized by progressive axon degeneration—whether, when, and how axonal transport is affected in this...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2014-12, Vol.84 (6), p.1183-1190
Hauptverfasser:	Sorbara, Catherine Diamante, Wagner, Naomi Elizabeth, Ladwig, Anne, Nikić, Ivana, Merkler, Doron, Kleele, Tatjana, Marinković, Petar, Naumann, Ronald, Godinho, Leanne, Bareyre, Florence Martine, Bishop, Derron, Misgeld, Thomas, Kerschensteiner, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axonal Transport - drug effects Axonal Transport - physiology Axons - physiology Cytoskeleton Disease Disease Models, Animal Free Radical Scavengers - pharmacology Functional Neuroimaging Mice Microscopy Microtubules - physiology Mitochondria Multiple Sclerosis - pathology Multiple Sclerosis - physiopathology Mutation Nerve Degeneration - physiopathology Neurodegeneration Nitric Oxide Donors - pharmacology Organelles - physiology Rodents Spermine - analogs & derivatives Spermine - pharmacology Spinal Cord - physiology
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