Astrocytic phospholipase A2 contributes to neuronal glutamate toxicity

Abstract The role of astrocytes in glutamate toxicity has been controversial. Here, we show that astrocytes in neuron–astrocyte co-cultures increased neuronal sensitivity to chronic glutamate exposure but not to acute exposure. Enhanced neuronal toxicity by chronic exposure was dependent on astrocyt...

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Veröffentlicht in:	Brain research 2014-11, Vol.1590, p.97-106
Hauptverfasser:	Ha, Jong Seong, Dho, So Hee, Youm, Tae Hyun, Kwon, Ki-Sun, Park, Sung Sup
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - enzymology Biological and medical sciences Cell Survival - drug effects Chronic glutamate toxicity Coculture Techniques Fundamental and applied biological sciences. Psychology Gene Knockdown Techniques Glutamic Acid - toxicity Hydrogen Peroxide - toxicity Lipoxygenase - metabolism Mice Mice, Inbred ICR Neurology Neurons - drug effects Neuron–astrocyte co-culture Oxidants - toxicity Phospholipase A2 (PLA2) Phospholipases A2 - genetics Phospholipases A2 - metabolism Primary Cell Culture Prostaglandin-Endoperoxide Synthases - metabolism Pure neuron culture Vertebrates: nervous system and sense organs
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