Caffeic acid phenethyl ester (CAPE) protects PC12 cells from MPP+ toxicity by inducing the expression of neuron-typical proteins

•Total inhibition of neuritogenesis is an early step in the neurotoxicity of MPP+.•CAPE induces neuritogenesis and synaptogenesis in non-NGF-stimulated PC12 cells.•CAPE increases the expression of GAP-43, synapsin and synaptophysin in PC12 cells.•CAPE inhibits the impairment of neuritogenesis and th...

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Veröffentlicht in:	Neurotoxicology (Park Forest South) 2014-12, Vol.45, p.131-138
Hauptverfasser:	Santos, Neife Aparecida Guinaim dos, Martins, Nádia Maria, Silva, Roberto de Barros, Ferreira, Rafaela Scalco, Sisti, Flávia Malvestio, Santos, Antonio Cardozo dos
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenylpyridinium - toxicity Animals Biological and medical sciences Caffeic Acids - therapeutic use CAPE (caffeic acid phenethyl ester) Cell Death - drug effects Cell Differentiation - drug effects Dose-Response Relationship, Drug GAP-43 GAP-43 Protein - metabolism Medical sciences Nerve Growth Factor - metabolism Neurites - drug effects Neuroprotection Neuroprotective Agents - therapeutic use PC12 Cells Phenylethyl Alcohol - analogs & derivatives Phenylethyl Alcohol - therapeutic use Prevention and actions Public health. Hygiene Public health. Hygiene-occupational medicine Rats Synapsin I Synapsins - metabolism Synaptophysin Synaptophysin - metabolism Toxicology
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