PolyI:C and mouse survivin artificially embedding human 2B peptide induce a CD4+ T cell response to autologous survivin in HLA-A2402 transgenic mice

Abstract CD4+ T cell effectors are crucial for establishing antitumor immunity. Dendritic cell maturation by immune adjuvants appears to facilitate subset-specific CD4+ T cell proliferation, but the adjuvant effect for CD4 T on induction of cytotoxic T lymphocytes (CTLs) is largely unknown. Self-ant...

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Veröffentlicht in:	Immunobiology (1979) 2015-01, Vol.220 (1), p.74-82
Hauptverfasser:	Kasamatsu, Jun, Takahashi, Shojiro, Azuma, Masahiro, Matsumoto, Misako, Morii-Sakai, Akiko, Imamura, Masahiro, Teshima, Takanori, Takahashi, Akari, Hirohashi, Yoshihiko, Torigoe, Toshihiko, Sato, Noriyuki, Seya, Tsukasa
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Allergy and Immunology Amino Acid Sequence Animals Antibody Formation CD4 epitope CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Epitopes, T-Lymphocyte - chemistry Epitopes, T-Lymphocyte - genetics Epitopes, T-Lymphocyte - immunology Exons Gene Expression Gene Order Genetic Loci HLA-A24 Antigen - genetics Humans Inhibitor of Apoptosis Proteins - genetics Inhibitor of Apoptosis Proteins - immunology Interferon-γ Mice Mice, Transgenic Molecular Sequence Data Open Reading Frames Peptide Fragments - genetics Peptide Fragments - immunology Peptide vaccine Poly I-C - immunology PolyI:C Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Repressor Proteins - genetics Repressor Proteins - immunology Survivin Th1 response Tumor immunity
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