Bone turnover markers as predictive indicators of outcome in patients with breast cancer and bone metastases treated with bisphosphonates: Results from a 2-year multicentre observational study (ZOMAR study)

Abstract Background We evaluated the evolution and predictive value of bone turnover markers (BTMs) and circulating tumor cells (CTCs) with respect to mortality, disease progression (DP) and skeletal-related events (SREs), in patients with bone metastatic breast cancer (BmBCa). The correlation betwe...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2014-11, Vol.68, p.32-40
Hauptverfasser:	Barnadas, Agustí, Manso, Luis, de la Piedra, Concepción, Meseguer, Cristina, Crespo, Carmen, Gómez, Patricia, Calvo, Lourdes, Martinez, Purificación, Ruiz-Borrego, Manuel, Perelló, Antonia, Antón, Antonio, Codes, Manuel, Margelí, Mireia, Murias, Adolfo, Salvador, Javier, Seguí, Miguel Ángel, de Juan, Ana, Gavilá, Joaquín, Luque, María, Pérez, Diego, Zamora, Pilar, Arizcuma, Alberto, Chacón, José Ignacio, Heras, Lucía, Martin-Fernández, Marta, Mahillo-Fernández, Ignacio, Tusquets, Ignacio
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers - metabolism Bisphosphonates Bone metastases Bone Neoplasms - drug therapy Bone Neoplasms - secondary Bone Remodeling - drug effects Bone turnover markers Breast cancer Breast Neoplasms - pathology Circulating tumor cells Diphosphonates - pharmacology Diphosphonates - therapeutic use Disease Progression Female Humans Imidazoles - pharmacology Imidazoles - therapeutic use Kaplan-Meier Estimate Middle Aged Neoplastic Cells, Circulating - drug effects Neoplastic Cells, Circulating - pathology Orthopedics Proportional Hazards Models Treatment Outcome Zoledronic acid
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