Perifornical orexinergic neurons modulate REM sleep by influencing locus coeruleus neurons in rats

Highlights • Single dose of glutamatergic stimulation or sustained mild electrical stimulation of PeF significantly suppressed REMS. • Effect of electrical stimulation of PeF lasted longer than that of glutamatergic stimulation. • PeF stimulation-induced REMS suppression was prevented by simultaneou...

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Veröffentlicht in:	Neuroscience 2014-10, Vol.279, p.33-43
Hauptverfasser:	Choudhary, R.C, Khanday, M.A, Mitra, A, Mallick, B.N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Central Nervous System Agents - pharmacology chemical stimulation Electric Stimulation electrical stimulation Electrodes, Implanted Electroencephalography glutamate Glutamic Acid - metabolism Hypothalamic Area, Lateral - physiology Intracellular Signaling Peptides and Proteins - metabolism Locus Coeruleus - drug effects Locus Coeruleus - physiology Male Neurology Neurons - drug effects Neurons - physiology Neuropeptides - metabolism orexin 1 receptor Orexin Receptor Antagonists Orexin Receptors - metabolism Orexins Phenylurea Compounds - pharmacology Rats, Wistar SB-418024 Sleep, REM - drug effects Sleep, REM - physiology Wakefulness - drug effects Wakefulness - physiology
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