Preterm prelabor rupture of membranes (PPROM) is not associated with presence of viral genomes in the amniotic fluid
Abstract Background The role of viral infections in preterm prelabor rupture of the membranes (PPROM) is not established. Studies on the presence of viral genomes in the amniotic fluid (AF) collected in pregnancies complicated by PPROM show contradictory outcomes. Objectives To investigate AF sample...
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| Veröffentlicht in: | Journal of clinical virology 2013-11, Vol.58 (3), p.559-563 |
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| creator | Bopegamage, Shubhada Kacerovsky, Marian Tambor, Vojtech Musilova, Ivana Sarmirova, Sona Snelders, Eveline de Jong, Arjan S Vari, Sandor G Melchers, Willem J.G Galama, Jochem M.D |
| description | Abstract Background The role of viral infections in preterm prelabor rupture of the membranes (PPROM) is not established. Studies on the presence of viral genomes in the amniotic fluid (AF) collected in pregnancies complicated by PPROM show contradictory outcomes. Objectives To investigate AF samples of PPROM pregnancies for the presence of viral genomes. Study design AF samples from patients with PPROM were collected during a 4-year (2008–2012) observational study. 174 women were included with selection criteria of singleton pregnancy, PPROM, and maternal age of 18 years and above. PCR was used for detection of human cytomegalovirus (HCMV), herpes simplex virus (HSV), parvovirus B19, human adenoviruses (HAdV), enteroviruses (EV) and human parechovirus (HPeV). The selection of these viral targets was based on literature regarding screening of AF for presence of viral genomes. Results Only a single sample was positive out of the 174 tested AFs, HCMV DNA was detected. Conclusions PPROM is not associated with active viral infections. |
| doi_str_mv | 10.1016/j.jcv.2013.09.013 |
| format | Article |
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Studies on the presence of viral genomes in the amniotic fluid (AF) collected in pregnancies complicated by PPROM show contradictory outcomes. Objectives To investigate AF samples of PPROM pregnancies for the presence of viral genomes. Study design AF samples from patients with PPROM were collected during a 4-year (2008–2012) observational study. 174 women were included with selection criteria of singleton pregnancy, PPROM, and maternal age of 18 years and above. PCR was used for detection of human cytomegalovirus (HCMV), herpes simplex virus (HSV), parvovirus B19, human adenoviruses (HAdV), enteroviruses (EV) and human parechovirus (HPeV). The selection of these viral targets was based on literature regarding screening of AF for presence of viral genomes. Results Only a single sample was positive out of the 174 tested AFs, HCMV DNA was detected. Conclusions PPROM is not associated with active viral infections.</description><identifier>ISSN: 1386-6532</identifier><identifier>EISSN: 1873-5967</identifier><identifier>DOI: 10.1016/j.jcv.2013.09.013</identifier><identifier>PMID: 24113293</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Allergy and Immunology ; Amniotic fluid ; Amniotic Fluid - virology ; Female ; Fetal Membranes, Premature Rupture - etiology ; Genome, Viral ; Herpes simplex virus ; Human cytomegalovirus ; Humans ; Infectious Disease ; Parvovirus B19 ; Polymerase Chain Reaction ; Pregnancy ; Pregnancy outcome ; Premature rupture of membranes ; Viral genomes ; Viruses - genetics ; Viruses - isolation & purification ; Young Adult</subject><ispartof>Journal of clinical virology, 2013-11, Vol.58 (3), p.559-563</ispartof><rights>Elsevier B.V.</rights><rights>2013 Elsevier B.V.</rights><rights>Copyright © 2013 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-17a7c4a6e051fa70042c55a2415286e9379080869c95c862b189457e402ba2ef3</citedby><cites>FETCH-LOGICAL-c484t-17a7c4a6e051fa70042c55a2415286e9379080869c95c862b189457e402ba2ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1386653213004046$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24113293$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bopegamage, Shubhada</creatorcontrib><creatorcontrib>Kacerovsky, Marian</creatorcontrib><creatorcontrib>Tambor, Vojtech</creatorcontrib><creatorcontrib>Musilova, Ivana</creatorcontrib><creatorcontrib>Sarmirova, Sona</creatorcontrib><creatorcontrib>Snelders, Eveline</creatorcontrib><creatorcontrib>de Jong, Arjan S</creatorcontrib><creatorcontrib>Vari, Sandor G</creatorcontrib><creatorcontrib>Melchers, Willem J.G</creatorcontrib><creatorcontrib>Galama, Jochem M.D</creatorcontrib><title>Preterm prelabor rupture of membranes (PPROM) is not associated with presence of viral genomes in the amniotic fluid</title><title>Journal of clinical virology</title><addtitle>J Clin Virol</addtitle><description>Abstract Background The role of viral infections in preterm prelabor rupture of the membranes (PPROM) is not established. Studies on the presence of viral genomes in the amniotic fluid (AF) collected in pregnancies complicated by PPROM show contradictory outcomes. Objectives To investigate AF samples of PPROM pregnancies for the presence of viral genomes. Study design AF samples from patients with PPROM were collected during a 4-year (2008–2012) observational study. 174 women were included with selection criteria of singleton pregnancy, PPROM, and maternal age of 18 years and above. PCR was used for detection of human cytomegalovirus (HCMV), herpes simplex virus (HSV), parvovirus B19, human adenoviruses (HAdV), enteroviruses (EV) and human parechovirus (HPeV). The selection of these viral targets was based on literature regarding screening of AF for presence of viral genomes. Results Only a single sample was positive out of the 174 tested AFs, HCMV DNA was detected. Conclusions PPROM is not associated with active viral infections.</description><subject>Adult</subject><subject>Allergy and Immunology</subject><subject>Amniotic fluid</subject><subject>Amniotic Fluid - virology</subject><subject>Female</subject><subject>Fetal Membranes, Premature Rupture - etiology</subject><subject>Genome, Viral</subject><subject>Herpes simplex virus</subject><subject>Human cytomegalovirus</subject><subject>Humans</subject><subject>Infectious Disease</subject><subject>Parvovirus B19</subject><subject>Polymerase Chain Reaction</subject><subject>Pregnancy</subject><subject>Pregnancy outcome</subject><subject>Premature rupture of membranes</subject><subject>Viral genomes</subject><subject>Viruses - genetics</subject><subject>Viruses - isolation & purification</subject><subject>Young Adult</subject><issn>1386-6532</issn><issn>1873-5967</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkktv1TAQhSMEoqXwA9ggL8siwW87QkJCFS-pqFc81pbjTKhDEt_azkX99zjcwoIFrGYW5zuyz5mqekpwQzCRL8ZmdIeGYsIa3DZl3KtOiVasFq1U98vOtKylYPSkepTSiDERjKuH1QnlhDDastMq7yJkiDPaR5hsFyKK6z6vEVAY0AxzF-0CCZ3vdp-uPj5HPqElZGRTCs7bDD364fP1BidY3C_o4KOd0DdYwlxAv6B8DcjOiw_ZOzRMq-8fVw8GOyV4cjfPqq9v33y5eF9fXr37cPH6snZc81wTZZXjVgIWZLAKY06dELY8XlAtoWWqxRpr2bpWOC1pR3TLhQKOaWcpDOysOj_67mO4WSFlM_vkYJrKn8KaDJG8uGoi1P-lnEutOJG4SMlR6mJIKcJg9tHPNt4ags3WixlN6cVsvRjcmjIK8-zOfu1m6P8Qv4sogpdHAZQ8Dh6iSc5vkfY-gsumD_6f9q_-ot3kF-_s9B1uIY1hjUsJ2hCTqMHm83YY210QVkLFXLKfa5mxUQ</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Bopegamage, Shubhada</creator><creator>Kacerovsky, Marian</creator><creator>Tambor, Vojtech</creator><creator>Musilova, Ivana</creator><creator>Sarmirova, Sona</creator><creator>Snelders, Eveline</creator><creator>de Jong, Arjan S</creator><creator>Vari, Sandor G</creator><creator>Melchers, Willem J.G</creator><creator>Galama, Jochem M.D</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20131101</creationdate><title>Preterm prelabor rupture of membranes (PPROM) is not associated with presence of viral genomes in the amniotic fluid</title><author>Bopegamage, Shubhada ; Kacerovsky, Marian ; Tambor, Vojtech ; Musilova, Ivana ; Sarmirova, Sona ; Snelders, Eveline ; de Jong, Arjan S ; Vari, Sandor G ; Melchers, Willem J.G ; Galama, Jochem M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-17a7c4a6e051fa70042c55a2415286e9379080869c95c862b189457e402ba2ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Allergy and Immunology</topic><topic>Amniotic fluid</topic><topic>Amniotic Fluid - virology</topic><topic>Female</topic><topic>Fetal Membranes, Premature Rupture - etiology</topic><topic>Genome, Viral</topic><topic>Herpes simplex virus</topic><topic>Human cytomegalovirus</topic><topic>Humans</topic><topic>Infectious Disease</topic><topic>Parvovirus B19</topic><topic>Polymerase Chain Reaction</topic><topic>Pregnancy</topic><topic>Pregnancy outcome</topic><topic>Premature rupture of membranes</topic><topic>Viral genomes</topic><topic>Viruses - genetics</topic><topic>Viruses - isolation & purification</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bopegamage, Shubhada</creatorcontrib><creatorcontrib>Kacerovsky, Marian</creatorcontrib><creatorcontrib>Tambor, Vojtech</creatorcontrib><creatorcontrib>Musilova, Ivana</creatorcontrib><creatorcontrib>Sarmirova, Sona</creatorcontrib><creatorcontrib>Snelders, Eveline</creatorcontrib><creatorcontrib>de Jong, Arjan S</creatorcontrib><creatorcontrib>Vari, Sandor G</creatorcontrib><creatorcontrib>Melchers, Willem J.G</creatorcontrib><creatorcontrib>Galama, Jochem M.D</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of clinical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bopegamage, Shubhada</au><au>Kacerovsky, Marian</au><au>Tambor, Vojtech</au><au>Musilova, Ivana</au><au>Sarmirova, Sona</au><au>Snelders, Eveline</au><au>de Jong, Arjan S</au><au>Vari, Sandor G</au><au>Melchers, Willem J.G</au><au>Galama, Jochem M.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preterm prelabor rupture of membranes (PPROM) is not associated with presence of viral genomes in the amniotic fluid</atitle><jtitle>Journal of clinical virology</jtitle><addtitle>J Clin Virol</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>58</volume><issue>3</issue><spage>559</spage><epage>563</epage><pages>559-563</pages><issn>1386-6532</issn><eissn>1873-5967</eissn><abstract>Abstract Background The role of viral infections in preterm prelabor rupture of the membranes (PPROM) is not established. Studies on the presence of viral genomes in the amniotic fluid (AF) collected in pregnancies complicated by PPROM show contradictory outcomes. Objectives To investigate AF samples of PPROM pregnancies for the presence of viral genomes. Study design AF samples from patients with PPROM were collected during a 4-year (2008–2012) observational study. 174 women were included with selection criteria of singleton pregnancy, PPROM, and maternal age of 18 years and above. PCR was used for detection of human cytomegalovirus (HCMV), herpes simplex virus (HSV), parvovirus B19, human adenoviruses (HAdV), enteroviruses (EV) and human parechovirus (HPeV). The selection of these viral targets was based on literature regarding screening of AF for presence of viral genomes. Results Only a single sample was positive out of the 174 tested AFs, HCMV DNA was detected. Conclusions PPROM is not associated with active viral infections.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>24113293</pmid><doi>10.1016/j.jcv.2013.09.013</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Allergy and Immunology Amniotic fluid Amniotic Fluid - virology Female Fetal Membranes, Premature Rupture - etiology Genome, Viral Herpes simplex virus Human cytomegalovirus Humans Infectious Disease Parvovirus B19 Polymerase Chain Reaction Pregnancy Pregnancy outcome Premature rupture of membranes Viral genomes Viruses - genetics Viruses - isolation & purification Young Adult |
| title | Preterm prelabor rupture of membranes (PPROM) is not associated with presence of viral genomes in the amniotic fluid |
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