Biomarkers of occupational exposure to air pollution, inflammation and oxidative damage in taxi drivers
Exposure to environmental pollutants has been recognised as a risk factor for cardiovascular events. 1-hydroxypyrene (1-OHP) is a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs) from traffic-related air pollution. Experimental studies indicate that PAH exposure could be associated w...
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| Veröffentlicht in: | The Science of the total environment 2013-10, Vol.463-464, p.884-893 |
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| creator | Brucker, Natália Moro, Angela M. Charão, Mariele F. Durgante, Juliano Freitas, Fernando Baierle, Marília Nascimento, Sabrina Gauer, Bruna Bulcão, Rachel P. Bubols, Guilherme B. Ferrari, Pedro D. Thiesen, Flávia V. Gioda, Adriana Duarte, Marta M.M.F. de Castro, Iran Saldiva, Paulo H. Garcia, Solange C. |
| description | Exposure to environmental pollutants has been recognised as a risk factor for cardiovascular events. 1-hydroxypyrene (1-OHP) is a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs) from traffic-related air pollution. Experimental studies indicate that PAH exposure could be associated with inflammation and atherogenesis. Thus, the purpose of this study was to evaluate whether the biomarker of PAH exposure is associated with biomarkers of inflammation and oxidative stress and if these effects modulate the risk of developing cardiovascular diseases in workers exposed to air pollution. This study included 60 subjects, comprising 39 taxi drivers and 21 non-occupationally exposed persons. Environmental PM2.5 and benzo[a]pyrene (BaP) levels, in addition to biomarkers of exposure and oxidative damage, were determined. Inflammatory cytokines (IL-1β, IL-6, IL-10, TNF-α, IFN-γ and hs-CRP) and serum levels of oxidised LDL (ox-LDL), auto-antibodies (ox-LDL-Ab) and homocysteine (Hcy) were also evaluated. PM2.5 and BaP exhibited averages of 12.4±6.9μgm−3 and 1.0±0.6ngm−3, respectively. Urinary 1-OHP levels were increased in taxi drivers compared to the non-occupationally exposed subjects (p |
| doi_str_mv | 10.1016/j.scitotenv.2013.06.098 |
| format | Article |
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•Chronic exposure to air pollution was linked to increase of atherogenic predictors.•Higher homocysteine levels were found in taxi drivers.•1-OHP levels showed important influence on increase of IL-1β, IL-6 and TNF-α levels.•Air pollution was related to depletion of antioxidants leading to oxidative damage.</description><identifier>ISSN: 0048-9697</identifier><identifier>EISSN: 1879-1026</identifier><identifier>DOI: 10.1016/j.scitotenv.2013.06.098</identifier><identifier>PMID: 23872245</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>1-hydroxypyrene ; Air Pollution - adverse effects ; Automobile Driving - statistics & numerical data ; Biomarkers - blood ; Biomarkers - urine ; Brazil - epidemiology ; Carboxyhemoglobin - analysis ; Cardiovascular Diseases - chemically induced ; Creatinine - urine ; Humans ; Inflammation ; Inflammation - chemically induced ; Interleukin-1beta - blood ; Interleukin-1beta - urine ; Interleukin-6 - blood ; Interleukin-6 - urine ; Lipid Peroxidation - drug effects ; Male ; Middle Aged ; Occupational exposure ; Occupational Exposure - analysis ; Oxidative stress ; Oxidative Stress - drug effects ; Pyrenes - urine ; Risk Factors ; Taxi drivers ; Tumor Necrosis Factor-alpha - blood ; Tumor Necrosis Factor-alpha - urine</subject><ispartof>The Science of the total environment, 2013-10, Vol.463-464, p.884-893</ispartof><rights>2013 Elsevier B.V.</rights><rights>2013.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-ce9cf41d1b973f18703349b06eb6bff1c717538e1bb5095fed8ec1c89c4baf523</citedby><cites>FETCH-LOGICAL-c536t-ce9cf41d1b973f18703349b06eb6bff1c717538e1bb5095fed8ec1c89c4baf523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S004896971300750X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23872245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brucker, Natália</creatorcontrib><creatorcontrib>Moro, Angela M.</creatorcontrib><creatorcontrib>Charão, Mariele F.</creatorcontrib><creatorcontrib>Durgante, Juliano</creatorcontrib><creatorcontrib>Freitas, Fernando</creatorcontrib><creatorcontrib>Baierle, Marília</creatorcontrib><creatorcontrib>Nascimento, Sabrina</creatorcontrib><creatorcontrib>Gauer, Bruna</creatorcontrib><creatorcontrib>Bulcão, Rachel P.</creatorcontrib><creatorcontrib>Bubols, Guilherme B.</creatorcontrib><creatorcontrib>Ferrari, Pedro D.</creatorcontrib><creatorcontrib>Thiesen, Flávia V.</creatorcontrib><creatorcontrib>Gioda, Adriana</creatorcontrib><creatorcontrib>Duarte, Marta M.M.F.</creatorcontrib><creatorcontrib>de Castro, Iran</creatorcontrib><creatorcontrib>Saldiva, Paulo H.</creatorcontrib><creatorcontrib>Garcia, Solange C.</creatorcontrib><title>Biomarkers of occupational exposure to air pollution, inflammation and oxidative damage in taxi drivers</title><title>The Science of the total environment</title><addtitle>Sci Total Environ</addtitle><description>Exposure to environmental pollutants has been recognised as a risk factor for cardiovascular events. 1-hydroxypyrene (1-OHP) is a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs) from traffic-related air pollution. Experimental studies indicate that PAH exposure could be associated with inflammation and atherogenesis. Thus, the purpose of this study was to evaluate whether the biomarker of PAH exposure is associated with biomarkers of inflammation and oxidative stress and if these effects modulate the risk of developing cardiovascular diseases in workers exposed to air pollution. This study included 60 subjects, comprising 39 taxi drivers and 21 non-occupationally exposed persons. Environmental PM2.5 and benzo[a]pyrene (BaP) levels, in addition to biomarkers of exposure and oxidative damage, were determined. Inflammatory cytokines (IL-1β, IL-6, IL-10, TNF-α, IFN-γ and hs-CRP) and serum levels of oxidised LDL (ox-LDL), auto-antibodies (ox-LDL-Ab) and homocysteine (Hcy) were also evaluated. PM2.5 and BaP exhibited averages of 12.4±6.9μgm−3 and 1.0±0.6ngm−3, respectively. Urinary 1-OHP levels were increased in taxi drivers compared to the non-occupationally exposed subjects (p<0.05) and were positively correlated with pro-inflammatory cytokines and negatively correlated with antioxidants. Furthermore, taxi drivers had elevated pro-inflammatory cytokines, biomarkers of oxidative damage, and ox-LDL, ox-LDL-Ab and Hcy levels, although antioxidant enzymes were decreased compared to the non-occupationally exposed subjects (p<0.05). In summary, our findings indicate that taxi drivers showed major exposure to pollutants, such as PAHs, in relation to non-occupationally exposed subjects. This finding was associated with higher inflammatory biomarkers and Hcy, which represent important predictors for cardiovascular events. These data suggest a contribution of PAHs to cardiovascular diseases upon occupational exposure.
•Chronic exposure to air pollution was linked to increase of atherogenic predictors.•Higher homocysteine levels were found in taxi drivers.•1-OHP levels showed important influence on increase of IL-1β, IL-6 and TNF-α levels.•Air pollution was related to depletion of antioxidants leading to oxidative damage.</description><subject>1-hydroxypyrene</subject><subject>Air Pollution - adverse effects</subject><subject>Automobile Driving - statistics & numerical data</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - urine</subject><subject>Brazil - epidemiology</subject><subject>Carboxyhemoglobin - analysis</subject><subject>Cardiovascular Diseases - chemically induced</subject><subject>Creatinine - urine</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - chemically induced</subject><subject>Interleukin-1beta - blood</subject><subject>Interleukin-1beta - urine</subject><subject>Interleukin-6 - blood</subject><subject>Interleukin-6 - urine</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Occupational exposure</subject><subject>Occupational Exposure - analysis</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Pyrenes - urine</subject><subject>Risk Factors</subject><subject>Taxi drivers</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Tumor Necrosis Factor-alpha - urine</subject><issn>0048-9697</issn><issn>1879-1026</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtv1DAURi0EokPhL4CXLEjwK34sSwUUqRIbWFuOc115SOJgJ6Ph3-NhSretN5btc78r34PQO0paSqj8uG-Lj2taYT60jFDeEtkSo5-hHdXKNJQw-RztCBG6MdKoC_SqlD2pS2n6El0wrhVjotuhu08xTS7_glxwCjh5vy1ujWl2I4bjksqWAa8Ju5jxksZxO719wHEOo5umfyR284DTMQ71dAA8uMndQSXw6o4RD7le5vIavQhuLPDmfr9EP798_nF909x-__rt-uq28R2Xa-PB-CDoQHujeKh_IZwL0xMJvexDoF5R1XENtO87YroAgwZPvTZe9C50jF-i9-fcJaffG5TVTrF4GEc3Q9qKpVIoQmrEk1DGqCCCPAFlykjNha6oOqM-p1IyBLvkWCf8x1JiT-7s3j64syd3lkhb3dXKt_dNtn6C4aHuv6wKXJ0BqAM8RMinIJg9DDGDX-2Q4qNN_gJoH7DD</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Brucker, Natália</creator><creator>Moro, Angela M.</creator><creator>Charão, Mariele F.</creator><creator>Durgante, Juliano</creator><creator>Freitas, Fernando</creator><creator>Baierle, Marília</creator><creator>Nascimento, Sabrina</creator><creator>Gauer, Bruna</creator><creator>Bulcão, Rachel P.</creator><creator>Bubols, Guilherme B.</creator><creator>Ferrari, Pedro D.</creator><creator>Thiesen, Flávia V.</creator><creator>Gioda, Adriana</creator><creator>Duarte, Marta M.M.F.</creator><creator>de Castro, Iran</creator><creator>Saldiva, Paulo H.</creator><creator>Garcia, Solange C.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7T2</scope><scope>7TG</scope><scope>7TV</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>KL.</scope><scope>SOI</scope><scope>7SU</scope><scope>8FD</scope><scope>FR3</scope></search><sort><creationdate>20131001</creationdate><title>Biomarkers of occupational exposure to air pollution, inflammation and oxidative damage in taxi drivers</title><author>Brucker, Natália ; Moro, Angela M. ; Charão, Mariele F. ; Durgante, Juliano ; Freitas, Fernando ; Baierle, Marília ; Nascimento, Sabrina ; Gauer, Bruna ; Bulcão, Rachel P. ; Bubols, Guilherme B. ; Ferrari, Pedro D. ; Thiesen, Flávia V. ; Gioda, Adriana ; Duarte, Marta M.M.F. ; de Castro, Iran ; Saldiva, Paulo H. ; Garcia, Solange C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-ce9cf41d1b973f18703349b06eb6bff1c717538e1bb5095fed8ec1c89c4baf523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>1-hydroxypyrene</topic><topic>Air Pollution - adverse effects</topic><topic>Automobile Driving - statistics & numerical data</topic><topic>Biomarkers - blood</topic><topic>Biomarkers - urine</topic><topic>Brazil - epidemiology</topic><topic>Carboxyhemoglobin - analysis</topic><topic>Cardiovascular Diseases - chemically induced</topic><topic>Creatinine - urine</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - chemically induced</topic><topic>Interleukin-1beta - blood</topic><topic>Interleukin-1beta - urine</topic><topic>Interleukin-6 - blood</topic><topic>Interleukin-6 - urine</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Occupational exposure</topic><topic>Occupational Exposure - analysis</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Pyrenes - urine</topic><topic>Risk Factors</topic><topic>Taxi drivers</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Tumor Necrosis Factor-alpha - urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brucker, Natália</creatorcontrib><creatorcontrib>Moro, Angela M.</creatorcontrib><creatorcontrib>Charão, Mariele F.</creatorcontrib><creatorcontrib>Durgante, Juliano</creatorcontrib><creatorcontrib>Freitas, Fernando</creatorcontrib><creatorcontrib>Baierle, Marília</creatorcontrib><creatorcontrib>Nascimento, Sabrina</creatorcontrib><creatorcontrib>Gauer, Bruna</creatorcontrib><creatorcontrib>Bulcão, Rachel P.</creatorcontrib><creatorcontrib>Bubols, Guilherme B.</creatorcontrib><creatorcontrib>Ferrari, Pedro D.</creatorcontrib><creatorcontrib>Thiesen, Flávia V.</creatorcontrib><creatorcontrib>Gioda, Adriana</creatorcontrib><creatorcontrib>Duarte, Marta M.M.F.</creatorcontrib><creatorcontrib>de Castro, Iran</creatorcontrib><creatorcontrib>Saldiva, Paulo H.</creatorcontrib><creatorcontrib>Garcia, Solange C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Pollution Abstracts</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>Environment Abstracts</collection><collection>Environmental Engineering Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><jtitle>The Science of the total environment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brucker, Natália</au><au>Moro, Angela M.</au><au>Charão, Mariele F.</au><au>Durgante, Juliano</au><au>Freitas, Fernando</au><au>Baierle, Marília</au><au>Nascimento, Sabrina</au><au>Gauer, Bruna</au><au>Bulcão, Rachel P.</au><au>Bubols, Guilherme B.</au><au>Ferrari, Pedro D.</au><au>Thiesen, Flávia V.</au><au>Gioda, Adriana</au><au>Duarte, Marta M.M.F.</au><au>de Castro, Iran</au><au>Saldiva, Paulo H.</au><au>Garcia, Solange C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biomarkers of occupational exposure to air pollution, inflammation and oxidative damage in taxi drivers</atitle><jtitle>The Science of the total environment</jtitle><addtitle>Sci Total Environ</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>463-464</volume><spage>884</spage><epage>893</epage><pages>884-893</pages><issn>0048-9697</issn><eissn>1879-1026</eissn><abstract>Exposure to environmental pollutants has been recognised as a risk factor for cardiovascular events. 1-hydroxypyrene (1-OHP) is a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs) from traffic-related air pollution. Experimental studies indicate that PAH exposure could be associated with inflammation and atherogenesis. Thus, the purpose of this study was to evaluate whether the biomarker of PAH exposure is associated with biomarkers of inflammation and oxidative stress and if these effects modulate the risk of developing cardiovascular diseases in workers exposed to air pollution. This study included 60 subjects, comprising 39 taxi drivers and 21 non-occupationally exposed persons. Environmental PM2.5 and benzo[a]pyrene (BaP) levels, in addition to biomarkers of exposure and oxidative damage, were determined. Inflammatory cytokines (IL-1β, IL-6, IL-10, TNF-α, IFN-γ and hs-CRP) and serum levels of oxidised LDL (ox-LDL), auto-antibodies (ox-LDL-Ab) and homocysteine (Hcy) were also evaluated. PM2.5 and BaP exhibited averages of 12.4±6.9μgm−3 and 1.0±0.6ngm−3, respectively. Urinary 1-OHP levels were increased in taxi drivers compared to the non-occupationally exposed subjects (p<0.05) and were positively correlated with pro-inflammatory cytokines and negatively correlated with antioxidants. Furthermore, taxi drivers had elevated pro-inflammatory cytokines, biomarkers of oxidative damage, and ox-LDL, ox-LDL-Ab and Hcy levels, although antioxidant enzymes were decreased compared to the non-occupationally exposed subjects (p<0.05). In summary, our findings indicate that taxi drivers showed major exposure to pollutants, such as PAHs, in relation to non-occupationally exposed subjects. This finding was associated with higher inflammatory biomarkers and Hcy, which represent important predictors for cardiovascular events. These data suggest a contribution of PAHs to cardiovascular diseases upon occupational exposure.
•Chronic exposure to air pollution was linked to increase of atherogenic predictors.•Higher homocysteine levels were found in taxi drivers.•1-OHP levels showed important influence on increase of IL-1β, IL-6 and TNF-α levels.•Air pollution was related to depletion of antioxidants leading to oxidative damage.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>23872245</pmid><doi>10.1016/j.scitotenv.2013.06.098</doi><tpages>10</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 1-hydroxypyrene Air Pollution - adverse effects Automobile Driving - statistics & numerical data Biomarkers - blood Biomarkers - urine Brazil - epidemiology Carboxyhemoglobin - analysis Cardiovascular Diseases - chemically induced Creatinine - urine Humans Inflammation Inflammation - chemically induced Interleukin-1beta - blood Interleukin-1beta - urine Interleukin-6 - blood Interleukin-6 - urine Lipid Peroxidation - drug effects Male Middle Aged Occupational exposure Occupational Exposure - analysis Oxidative stress Oxidative Stress - drug effects Pyrenes - urine Risk Factors Taxi drivers Tumor Necrosis Factor-alpha - blood Tumor Necrosis Factor-alpha - urine |
| title | Biomarkers of occupational exposure to air pollution, inflammation and oxidative damage in taxi drivers |
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