Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL)

[Display omitted] The key hydrolytic enzymes of the endocannabinoid system, fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), are potential targets for various therapeutic applications. In this paper, we present more extensively the results of our previous work on piperazine and...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2014-12, Vol.22 (23), p.6694-6705
Hauptverfasser:	Korhonen, Jani, Kuusisto, Anne, van Bruchem, John, Patel, Jayendra Z., Laitinen, Tuomo, Navia-Paldanius, Dina, Laitinen, Jarmo T., Savinainen, Juha R., Parkkari, Teija, Nevalainen, Tapio J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemical synthesis Amides - chemistry Amides - pharmacology Amidohydrolases - antagonists & inhibitors Amidohydrolases - metabolism Carbamates - chemical synthesis Carbamates - chemistry Carbamates - pharmacology Dose-Response Relationship, Drug Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology FAAH and MAGL inhibitors Fatty acid amide hydrolase (FAAH) HEK293 Cells Humans Models, Molecular Molecular Structure Monoacylglycerol lipase (MAGL) Monoacylglycerol Lipases - antagonists & inhibitors Monoacylglycerol Lipases - metabolism Piperazines - chemical synthesis Piperazines - chemistry Piperazines - pharmacology Piperidines - chemical synthesis Piperidines - chemistry Piperidines - pharmacology Structure-Activity Relationship
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