Urinary paraben concentrations among pregnant women and their matching newborn infants of Korea, and the association with oxidative stress biomarkers
Parabens have been used in multiple products including personal care products, pharmaceuticals, and foods for more than 50years but increasing numbers of studies have raised concerns on their safety. The present study was designed to determine urinary paraben levels among pregnant women and their ma...
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| Veröffentlicht in: | The Science of the total environment 2013-09, Vol.461-462, p.214-221 |
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| creator | Kang, Sungeun Kim, Sunmi Park, Jeongim Kim, Hae-Joong Lee, Jeongjae Choi, Gyuyeon Choi, Sooran Kim, Sungjoo Kim, Su Young Moon, Hyo-Bang Kim, Sungkyoon Kho, Young Lim Choi, Kyungho |
| description | Parabens have been used in multiple products including personal care products, pharmaceuticals, and foods for more than 50years but increasing numbers of studies have raised concerns on their safety. The present study was designed to determine urinary paraben levels among pregnant women and their matching newborn infants ( |
| doi_str_mv | 10.1016/j.scitotenv.2013.04.097 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1647003924</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S004896971300538X</els_id><sourcerecordid>1647003924</sourcerecordid><originalsourceid>FETCH-LOGICAL-c437t-7f36ade92f74486b890444be80c2768a424630c9b85b6bbdb2c96e7022c17a1d3</originalsourceid><addsrcrecordid>eNqNkU1vVCEUhonR2LH6F5SlC-8VuJSPZdPUamzixq4JcM_tMM6FEZgZ-0P8v2WcttvKAkLynPck74PQB0p6Sqj4vOqLDzVViLueETr0hPdEyxdoQZXUHSVMvEQLQrjqtNDyBL0pZUXakYq-RidskExqfbZAf29yiDbf4Y3N1kHEPkUPsWZbQ4oF2znFW7zJcBttrHif5sbYOOK6hJDxbKtfhkZE2LuUIw5xalzBacLfUwb76RHGtpTkw79YvA91idOfMLbvDnCpGUrBLqTZ5l-Qy1v0arLrAu8e3lN08-Xy58XX7vrH1beL8-vO80HWTk6DsCNoNknOlXBKE865A0U8k0JZzrgYiNdOnTnh3OiY1wIkYcxTaek4nKKPx9xNTr-3UKqZQ_GwXtsIaVsMFVwSMmjG_wNtjUrZ7udRThXlmuqhofKI-pxKyTCZTQ6thDtDiTmYNivzZNocTBvCTTPdJt8_LNm6GcanuUe1DTg_AtAK3AXIhyBocseQwVczpvDsknsYD8GL</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1418149193</pqid></control><display><type>article</type><title>Urinary paraben concentrations among pregnant women and their matching newborn infants of Korea, and the association with oxidative stress biomarkers</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Kang, Sungeun ; Kim, Sunmi ; Park, Jeongim ; Kim, Hae-Joong ; Lee, Jeongjae ; Choi, Gyuyeon ; Choi, Sooran ; Kim, Sungjoo ; Kim, Su Young ; Moon, Hyo-Bang ; Kim, Sungkyoon ; Kho, Young Lim ; Choi, Kyungho</creator><creatorcontrib>Kang, Sungeun ; Kim, Sunmi ; Park, Jeongim ; Kim, Hae-Joong ; Lee, Jeongjae ; Choi, Gyuyeon ; Choi, Sooran ; Kim, Sungjoo ; Kim, Su Young ; Moon, Hyo-Bang ; Kim, Sungkyoon ; Kho, Young Lim ; Choi, Kyungho</creatorcontrib><description>Parabens have been used in multiple products including personal care products, pharmaceuticals, and foods for more than 50years but increasing numbers of studies have raised concerns on their safety. The present study was designed to determine urinary paraben levels among pregnant women and their matching newborn infants (<48h after delivery), and the association between paraben levels and stress markers. Pregnant women (n=46) and their matching newborn infants were recruited from four university hospitals located in Seoul, Ansan and Jeju of Korea, 2011. Parabens including methyl paraben (MP), ethyl paraben (EP), n-propyl paraben (PP), and n-butyl paraben (BP) were measured in the urine using an automatic, high throughput online SPE–LC–MS/MS method. Urinary concentrations were normalized with specific gravity (SG). Free cortisol, malondealdehyde (MDA) and 8-hydroxydeoxyguanosine (8-OHdG) were measured in the urine as stress marker. Urinary MP was detected as the highest, and BP was detected as the lowest paraben in the urine samples of both pregnant women and their infants. Significant correlations between paraben concentrations of maternal and their newborn infant's urine were observed. The levels of urinary parabens among Korean pregnant women are comparable to those reported elsewhere, except for EP which were 4–9 folds higher than pregnant women of other countries. The ratios of infant to maternal urinary paraben concentrations varied between 0.5 and 0.6 for MP and PP, but approximately 10 fold lower for EP. Urinary MP or EP levels were associated with several oxidative stress related biomarkers such as urinary 8-OHdG and MDA, even after the adjustment of relevant covariates such as maternal age, mode of delivery, pre-pregnancy BMI, gestational age and parity. This is the first study that reported the levels of major parabens in the first urine of newborn infants. Further studies are warranted to understand the implications of paraben exposure among biologically susceptible human populations.
•Four parabens were measured in the urine of pregnant women and their matching infants.•Urinary EP levels of pregnant women were 4–9 folds higher than other countries.•MP or EP levels were associated with stress markers in maternal or fetal urine.•Consequences of paraben exposure among sensitive humans deserve further study.</description><identifier>ISSN: 0048-9697</identifier><identifier>EISSN: 1879-1026</identifier><identifier>DOI: 10.1016/j.scitotenv.2013.04.097</identifier><identifier>PMID: 23727995</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Biomarkers - urine ; Chromatography, Liquid ; Deoxyguanosine - analogs & derivatives ; Deoxyguanosine - urine ; DNA Primers - genetics ; Ethyl paraben ; Female ; Humans ; Hydrocortisone - urine ; Malondialdehyde - urine ; Methyl paraben ; Oxidative stress ; Oxidative Stress - physiology ; Parabens - metabolism ; Placenta ; Polymerase Chain Reaction ; Pregnancy ; Regression Analysis ; Republic of Korea ; Statistics, Nonparametric ; Tandem Mass Spectrometry ; Urine</subject><ispartof>The Science of the total environment, 2013-09, Vol.461-462, p.214-221</ispartof><rights>2013 Elsevier B.V.</rights><rights>Copyright © 2013 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-7f36ade92f74486b890444be80c2768a424630c9b85b6bbdb2c96e7022c17a1d3</citedby><cites>FETCH-LOGICAL-c437t-7f36ade92f74486b890444be80c2768a424630c9b85b6bbdb2c96e7022c17a1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S004896971300538X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23727995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kang, Sungeun</creatorcontrib><creatorcontrib>Kim, Sunmi</creatorcontrib><creatorcontrib>Park, Jeongim</creatorcontrib><creatorcontrib>Kim, Hae-Joong</creatorcontrib><creatorcontrib>Lee, Jeongjae</creatorcontrib><creatorcontrib>Choi, Gyuyeon</creatorcontrib><creatorcontrib>Choi, Sooran</creatorcontrib><creatorcontrib>Kim, Sungjoo</creatorcontrib><creatorcontrib>Kim, Su Young</creatorcontrib><creatorcontrib>Moon, Hyo-Bang</creatorcontrib><creatorcontrib>Kim, Sungkyoon</creatorcontrib><creatorcontrib>Kho, Young Lim</creatorcontrib><creatorcontrib>Choi, Kyungho</creatorcontrib><title>Urinary paraben concentrations among pregnant women and their matching newborn infants of Korea, and the association with oxidative stress biomarkers</title><title>The Science of the total environment</title><addtitle>Sci Total Environ</addtitle><description>Parabens have been used in multiple products including personal care products, pharmaceuticals, and foods for more than 50years but increasing numbers of studies have raised concerns on their safety. The present study was designed to determine urinary paraben levels among pregnant women and their matching newborn infants (<48h after delivery), and the association between paraben levels and stress markers. Pregnant women (n=46) and their matching newborn infants were recruited from four university hospitals located in Seoul, Ansan and Jeju of Korea, 2011. Parabens including methyl paraben (MP), ethyl paraben (EP), n-propyl paraben (PP), and n-butyl paraben (BP) were measured in the urine using an automatic, high throughput online SPE–LC–MS/MS method. Urinary concentrations were normalized with specific gravity (SG). Free cortisol, malondealdehyde (MDA) and 8-hydroxydeoxyguanosine (8-OHdG) were measured in the urine as stress marker. Urinary MP was detected as the highest, and BP was detected as the lowest paraben in the urine samples of both pregnant women and their infants. Significant correlations between paraben concentrations of maternal and their newborn infant's urine were observed. The levels of urinary parabens among Korean pregnant women are comparable to those reported elsewhere, except for EP which were 4–9 folds higher than pregnant women of other countries. The ratios of infant to maternal urinary paraben concentrations varied between 0.5 and 0.6 for MP and PP, but approximately 10 fold lower for EP. Urinary MP or EP levels were associated with several oxidative stress related biomarkers such as urinary 8-OHdG and MDA, even after the adjustment of relevant covariates such as maternal age, mode of delivery, pre-pregnancy BMI, gestational age and parity. This is the first study that reported the levels of major parabens in the first urine of newborn infants. Further studies are warranted to understand the implications of paraben exposure among biologically susceptible human populations.
•Four parabens were measured in the urine of pregnant women and their matching infants.•Urinary EP levels of pregnant women were 4–9 folds higher than other countries.•MP or EP levels were associated with stress markers in maternal or fetal urine.•Consequences of paraben exposure among sensitive humans deserve further study.</description><subject>Adult</subject><subject>Biomarkers - urine</subject><subject>Chromatography, Liquid</subject><subject>Deoxyguanosine - analogs & derivatives</subject><subject>Deoxyguanosine - urine</subject><subject>DNA Primers - genetics</subject><subject>Ethyl paraben</subject><subject>Female</subject><subject>Humans</subject><subject>Hydrocortisone - urine</subject><subject>Malondialdehyde - urine</subject><subject>Methyl paraben</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - physiology</subject><subject>Parabens - metabolism</subject><subject>Placenta</subject><subject>Polymerase Chain Reaction</subject><subject>Pregnancy</subject><subject>Regression Analysis</subject><subject>Republic of Korea</subject><subject>Statistics, Nonparametric</subject><subject>Tandem Mass Spectrometry</subject><subject>Urine</subject><issn>0048-9697</issn><issn>1879-1026</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1vVCEUhonR2LH6F5SlC-8VuJSPZdPUamzixq4JcM_tMM6FEZgZ-0P8v2WcttvKAkLynPck74PQB0p6Sqj4vOqLDzVViLueETr0hPdEyxdoQZXUHSVMvEQLQrjqtNDyBL0pZUXakYq-RidskExqfbZAf29yiDbf4Y3N1kHEPkUPsWZbQ4oF2znFW7zJcBttrHif5sbYOOK6hJDxbKtfhkZE2LuUIw5xalzBacLfUwb76RHGtpTkw79YvA91idOfMLbvDnCpGUrBLqTZ5l-Qy1v0arLrAu8e3lN08-Xy58XX7vrH1beL8-vO80HWTk6DsCNoNknOlXBKE865A0U8k0JZzrgYiNdOnTnh3OiY1wIkYcxTaek4nKKPx9xNTr-3UKqZQ_GwXtsIaVsMFVwSMmjG_wNtjUrZ7udRThXlmuqhofKI-pxKyTCZTQ6thDtDiTmYNivzZNocTBvCTTPdJt8_LNm6GcanuUe1DTg_AtAK3AXIhyBocseQwVczpvDsknsYD8GL</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Kang, Sungeun</creator><creator>Kim, Sunmi</creator><creator>Park, Jeongim</creator><creator>Kim, Hae-Joong</creator><creator>Lee, Jeongjae</creator><creator>Choi, Gyuyeon</creator><creator>Choi, Sooran</creator><creator>Kim, Sungjoo</creator><creator>Kim, Su Young</creator><creator>Moon, Hyo-Bang</creator><creator>Kim, Sungkyoon</creator><creator>Kho, Young Lim</creator><creator>Choi, Kyungho</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7ST</scope><scope>7TV</scope><scope>C1K</scope><scope>SOI</scope></search><sort><creationdate>20130901</creationdate><title>Urinary paraben concentrations among pregnant women and their matching newborn infants of Korea, and the association with oxidative stress biomarkers</title><author>Kang, Sungeun ; Kim, Sunmi ; Park, Jeongim ; Kim, Hae-Joong ; Lee, Jeongjae ; Choi, Gyuyeon ; Choi, Sooran ; Kim, Sungjoo ; Kim, Su Young ; Moon, Hyo-Bang ; Kim, Sungkyoon ; Kho, Young Lim ; Choi, Kyungho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-7f36ade92f74486b890444be80c2768a424630c9b85b6bbdb2c96e7022c17a1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Biomarkers - urine</topic><topic>Chromatography, Liquid</topic><topic>Deoxyguanosine - analogs & derivatives</topic><topic>Deoxyguanosine - urine</topic><topic>DNA Primers - genetics</topic><topic>Ethyl paraben</topic><topic>Female</topic><topic>Humans</topic><topic>Hydrocortisone - urine</topic><topic>Malondialdehyde - urine</topic><topic>Methyl paraben</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - physiology</topic><topic>Parabens - metabolism</topic><topic>Placenta</topic><topic>Polymerase Chain Reaction</topic><topic>Pregnancy</topic><topic>Regression Analysis</topic><topic>Republic of Korea</topic><topic>Statistics, Nonparametric</topic><topic>Tandem Mass Spectrometry</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, Sungeun</creatorcontrib><creatorcontrib>Kim, Sunmi</creatorcontrib><creatorcontrib>Park, Jeongim</creatorcontrib><creatorcontrib>Kim, Hae-Joong</creatorcontrib><creatorcontrib>Lee, Jeongjae</creatorcontrib><creatorcontrib>Choi, Gyuyeon</creatorcontrib><creatorcontrib>Choi, Sooran</creatorcontrib><creatorcontrib>Kim, Sungjoo</creatorcontrib><creatorcontrib>Kim, Su Young</creatorcontrib><creatorcontrib>Moon, Hyo-Bang</creatorcontrib><creatorcontrib>Kim, Sungkyoon</creatorcontrib><creatorcontrib>Kho, Young Lim</creatorcontrib><creatorcontrib>Choi, Kyungho</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Environment Abstracts</collection><collection>Pollution Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><jtitle>The Science of the total environment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, Sungeun</au><au>Kim, Sunmi</au><au>Park, Jeongim</au><au>Kim, Hae-Joong</au><au>Lee, Jeongjae</au><au>Choi, Gyuyeon</au><au>Choi, Sooran</au><au>Kim, Sungjoo</au><au>Kim, Su Young</au><au>Moon, Hyo-Bang</au><au>Kim, Sungkyoon</au><au>Kho, Young Lim</au><au>Choi, Kyungho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary paraben concentrations among pregnant women and their matching newborn infants of Korea, and the association with oxidative stress biomarkers</atitle><jtitle>The Science of the total environment</jtitle><addtitle>Sci Total Environ</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>461-462</volume><spage>214</spage><epage>221</epage><pages>214-221</pages><issn>0048-9697</issn><eissn>1879-1026</eissn><abstract>Parabens have been used in multiple products including personal care products, pharmaceuticals, and foods for more than 50years but increasing numbers of studies have raised concerns on their safety. The present study was designed to determine urinary paraben levels among pregnant women and their matching newborn infants (<48h after delivery), and the association between paraben levels and stress markers. Pregnant women (n=46) and their matching newborn infants were recruited from four university hospitals located in Seoul, Ansan and Jeju of Korea, 2011. Parabens including methyl paraben (MP), ethyl paraben (EP), n-propyl paraben (PP), and n-butyl paraben (BP) were measured in the urine using an automatic, high throughput online SPE–LC–MS/MS method. Urinary concentrations were normalized with specific gravity (SG). Free cortisol, malondealdehyde (MDA) and 8-hydroxydeoxyguanosine (8-OHdG) were measured in the urine as stress marker. Urinary MP was detected as the highest, and BP was detected as the lowest paraben in the urine samples of both pregnant women and their infants. Significant correlations between paraben concentrations of maternal and their newborn infant's urine were observed. The levels of urinary parabens among Korean pregnant women are comparable to those reported elsewhere, except for EP which were 4–9 folds higher than pregnant women of other countries. The ratios of infant to maternal urinary paraben concentrations varied between 0.5 and 0.6 for MP and PP, but approximately 10 fold lower for EP. Urinary MP or EP levels were associated with several oxidative stress related biomarkers such as urinary 8-OHdG and MDA, even after the adjustment of relevant covariates such as maternal age, mode of delivery, pre-pregnancy BMI, gestational age and parity. This is the first study that reported the levels of major parabens in the first urine of newborn infants. Further studies are warranted to understand the implications of paraben exposure among biologically susceptible human populations.
•Four parabens were measured in the urine of pregnant women and their matching infants.•Urinary EP levels of pregnant women were 4–9 folds higher than other countries.•MP or EP levels were associated with stress markers in maternal or fetal urine.•Consequences of paraben exposure among sensitive humans deserve further study.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>23727995</pmid><doi>10.1016/j.scitotenv.2013.04.097</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Biomarkers - urine Chromatography, Liquid Deoxyguanosine - analogs & derivatives Deoxyguanosine - urine DNA Primers - genetics Ethyl paraben Female Humans Hydrocortisone - urine Malondialdehyde - urine Methyl paraben Oxidative stress Oxidative Stress - physiology Parabens - metabolism Placenta Polymerase Chain Reaction Pregnancy Regression Analysis Republic of Korea Statistics, Nonparametric Tandem Mass Spectrometry Urine |
| title | Urinary paraben concentrations among pregnant women and their matching newborn infants of Korea, and the association with oxidative stress biomarkers |
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