Wnt5a signaling increases IL-12 secretion by human dendritic cells and enhances IFN-γ production by CD4+ T cells

Highlights • The expression of Wnt receptor is regulated during DC life cycle. • Wnt5a is expressed by DCs and its production increases upon specific stimulation. • Wnt5a is not a stimulatory signal for iDCs. • Autocrine Wnt5a production is necessary for DC function. • Wnt5a enhances IL-2 and IFNγ p...

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Veröffentlicht in:	Immunology letters 2014-11, Vol.162 (1), p.188-199
Hauptverfasser:	Valencia, Jaris, Martínez, Víctor G, Hidalgo, Laura, Hernández-López, Carmen, Canseco, Noelia M, Vicente, Ángeles, Varas, Alberto, Sacedón, Rosa
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Autocrine Communication CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cell Differentiation - drug effects Cells, Cultured Cytokines - metabolism Cytokines - pharmacology DCs Dendritic Cells - cytology Dendritic Cells - immunology Dendritic Cells - metabolism Gene Expression Gene Expression Profiling Humans IFN-γ IL-10 IL-12 Interferon-gamma - biosynthesis Interleukin-12 - biosynthesis Ligands Proto-Oncogene Proteins - metabolism Receptors, Wnt - genetics Receptors, Wnt - metabolism Signal Transduction T-cell Toll-Like Receptors - metabolism Wnt Wnt Proteins - genetics Wnt Proteins - metabolism Wnt-5a Protein Wnt4 Protein - genetics Wnt4 Protein - metabolism
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Zusammenfassung:	Highlights • The expression of Wnt receptor is regulated during DC life cycle. • Wnt5a is expressed by DCs and its production increases upon specific stimulation. • Wnt5a is not a stimulatory signal for iDCs. • Autocrine Wnt5a production is necessary for DC function. • Wnt5a enhances IL-2 and IFNγ production by stimulated naïve CD4+ T cells.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2014.08.015