Maintaining tissue selenium species distribution as a potential defense mechanism against methylmercury toxicity in juvenile white sturgeon (Acipenser transmontanus)
•MeHg exposure mobilized endogenous Se from storage.•Co-exposure to MeHg increased de novo synthesis of biologically active Se forms in most tissues.•MeHg exposure resulted in transformation of the exogenous SeMet in the liver.•Selenocompound distribution in the kidneys was not affected by the expos...
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description | •MeHg exposure mobilized endogenous Se from storage.•Co-exposure to MeHg increased de novo synthesis of biologically active Se forms in most tissues.•MeHg exposure resulted in transformation of the exogenous SeMet in the liver.•Selenocompound distribution in the kidneys was not affected by the exposure to MeHg.•When exposed to MeHg, maintaining levels of certain Se species is more important than total [Se].
Selenium (Se) has been shown to antagonize mercury (Hg) toxicity. We have previously demonstrated that orally intubated selenomethionine (SeMet) and methylmercury (MeHg) reduced tissue Se accumulation, as well as blood and kidney Hg concentrations in juvenile white sturgeon (Acipenser transmontanus). However, the form of Se accumulated is not known. In this study, three organoseleniums: selenocysteine (Sec), Se-methyl-selenocysteine (MSeCys), and SeMet and two inorganic Se species: selenate and selenite were determined and quantified in the blood at different post-intubation periods (12, 24, 48h) and in the muscle, liver, and kidneys at 48h in white sturgeon orally intubated with a single dose of control (carrier), SeMet (500μg Se/kg body weight; BW), MeHg (850μg Hg/kg BW), and both (Se+Hg; at 500μg Se/kg and 850μg Hg/kg BW). When only SeMet was intubated, the accumulative/unmodified pathway took precedent in the blood, white muscle, liver, and kidneys. In the presence of MeHg, however, active metabolic transformation and de novo synthesis of biologically active Se forms are seen in the liver and kidneys, as indicated by a gradual increase in blood Sec:SeMet ratios and Se metabolites. In the white muscle, mobilization of endogenous Se storage by MeHg is supported by the absence of tissue SeMet and detectable levels of blood SeMet. In contrast, co-intubation with SeMet increased muscle SeMet. The high levels of unknown Se metabolites and detectable levels of selenite in the kidney reflect its role as the major excretory organ for Se. Selenium metabolism is highly regulated in the kidneys, as Se speciation was not affected by MeHg or by its co-intubation with SeMet. In the Se+Hg group, the proportion of SeMet in the liver has decreased to nearly 1/8th of that of the SeMet only group, resulting in a more similar selenocompound distribution profile to that of the MeHg only group. This is likely due to the increased need for Se metabolites necessary for MeHg demethylation in the liver. Our study demonstrated that in the presence of MeHg, regulating tissue Se |
doi_str_mv | 10.1016/j.aquatox.2014.08.004 |
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Selenium (Se) has been shown to antagonize mercury (Hg) toxicity. We have previously demonstrated that orally intubated selenomethionine (SeMet) and methylmercury (MeHg) reduced tissue Se accumulation, as well as blood and kidney Hg concentrations in juvenile white sturgeon (Acipenser transmontanus). However, the form of Se accumulated is not known. In this study, three organoseleniums: selenocysteine (Sec), Se-methyl-selenocysteine (MSeCys), and SeMet and two inorganic Se species: selenate and selenite were determined and quantified in the blood at different post-intubation periods (12, 24, 48h) and in the muscle, liver, and kidneys at 48h in white sturgeon orally intubated with a single dose of control (carrier), SeMet (500μg Se/kg body weight; BW), MeHg (850μg Hg/kg BW), and both (Se+Hg; at 500μg Se/kg and 850μg Hg/kg BW). When only SeMet was intubated, the accumulative/unmodified pathway took precedent in the blood, white muscle, liver, and kidneys. In the presence of MeHg, however, active metabolic transformation and de novo synthesis of biologically active Se forms are seen in the liver and kidneys, as indicated by a gradual increase in blood Sec:SeMet ratios and Se metabolites. In the white muscle, mobilization of endogenous Se storage by MeHg is supported by the absence of tissue SeMet and detectable levels of blood SeMet. In contrast, co-intubation with SeMet increased muscle SeMet. The high levels of unknown Se metabolites and detectable levels of selenite in the kidney reflect its role as the major excretory organ for Se. Selenium metabolism is highly regulated in the kidneys, as Se speciation was not affected by MeHg or by its co-intubation with SeMet. In the Se+Hg group, the proportion of SeMet in the liver has decreased to nearly 1/8th of that of the SeMet only group, resulting in a more similar selenocompound distribution profile to that of the MeHg only group. This is likely due to the increased need for Se metabolites necessary for MeHg demethylation in the liver. Our study demonstrated that in the presence of MeHg, regulating tissue Se speciation, hence, Se bioavailability, is more an important strategy than maintaining total Se levels in major organs of juvenile white sturgeon.</description><identifier>ISSN: 0166-445X</identifier><identifier>EISSN: 1879-1514</identifier><identifier>DOI: 10.1016/j.aquatox.2014.08.004</identifier><identifier>PMID: 25170596</identifier><identifier>CODEN: AQTODG</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Acipenser ; Acipenser transmontanus ; Agnatha. Pisces ; Animal, plant and microbial ecology ; Animals ; Applied ecology ; Biological and medical sciences ; Ecotoxicology, biological effects of pollution ; Effects of pollution and side effects of pesticides on vertebrates ; Fishes - metabolism ; Fundamental and applied biological sciences. Psychology ; Kidney - drug effects ; Kidney - metabolism ; Liver - drug effects ; Liver - metabolism ; Mercury - metabolism ; Methylmercury ; Methylmercury Compounds - toxicity ; Se bioavailability ; Se metabolism ; Se speciation ; Selenium - metabolism ; Selenium Compounds - metabolism ; Selenocompounds ; Selenocysteine - analogs & derivatives ; Selenocysteine - metabolism ; Selenomethionine ; Selenomethionine - metabolism ; Tissue Distribution ; Water Pollutants, Chemical - metabolism ; Water Pollutants, Chemical - toxicity</subject><ispartof>Aquatic toxicology, 2014-11, Vol.156, p.88-95</ispartof><rights>2014 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-2073863f3b343db3c82684e5112fb6f87a953217716b262135882cbaa50116ee3</citedby><cites>FETCH-LOGICAL-c494t-2073863f3b343db3c82684e5112fb6f87a953217716b262135882cbaa50116ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.aquatox.2014.08.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28887737$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25170596$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Susie Shih-Yin</creatorcontrib><creatorcontrib>Hung, Silas S.O.</creatorcontrib><creatorcontrib>Chan, Hing Man</creatorcontrib><title>Maintaining tissue selenium species distribution as a potential defense mechanism against methylmercury toxicity in juvenile white sturgeon (Acipenser transmontanus)</title><title>Aquatic toxicology</title><addtitle>Aquat Toxicol</addtitle><description>•MeHg exposure mobilized endogenous Se from storage.•Co-exposure to MeHg increased de novo synthesis of biologically active Se forms in most tissues.•MeHg exposure resulted in transformation of the exogenous SeMet in the liver.•Selenocompound distribution in the kidneys was not affected by the exposure to MeHg.•When exposed to MeHg, maintaining levels of certain Se species is more important than total [Se].
Selenium (Se) has been shown to antagonize mercury (Hg) toxicity. We have previously demonstrated that orally intubated selenomethionine (SeMet) and methylmercury (MeHg) reduced tissue Se accumulation, as well as blood and kidney Hg concentrations in juvenile white sturgeon (Acipenser transmontanus). However, the form of Se accumulated is not known. In this study, three organoseleniums: selenocysteine (Sec), Se-methyl-selenocysteine (MSeCys), and SeMet and two inorganic Se species: selenate and selenite were determined and quantified in the blood at different post-intubation periods (12, 24, 48h) and in the muscle, liver, and kidneys at 48h in white sturgeon orally intubated with a single dose of control (carrier), SeMet (500μg Se/kg body weight; BW), MeHg (850μg Hg/kg BW), and both (Se+Hg; at 500μg Se/kg and 850μg Hg/kg BW). When only SeMet was intubated, the accumulative/unmodified pathway took precedent in the blood, white muscle, liver, and kidneys. In the presence of MeHg, however, active metabolic transformation and de novo synthesis of biologically active Se forms are seen in the liver and kidneys, as indicated by a gradual increase in blood Sec:SeMet ratios and Se metabolites. In the white muscle, mobilization of endogenous Se storage by MeHg is supported by the absence of tissue SeMet and detectable levels of blood SeMet. In contrast, co-intubation with SeMet increased muscle SeMet. The high levels of unknown Se metabolites and detectable levels of selenite in the kidney reflect its role as the major excretory organ for Se. Selenium metabolism is highly regulated in the kidneys, as Se speciation was not affected by MeHg or by its co-intubation with SeMet. In the Se+Hg group, the proportion of SeMet in the liver has decreased to nearly 1/8th of that of the SeMet only group, resulting in a more similar selenocompound distribution profile to that of the MeHg only group. This is likely due to the increased need for Se metabolites necessary for MeHg demethylation in the liver. Our study demonstrated that in the presence of MeHg, regulating tissue Se speciation, hence, Se bioavailability, is more an important strategy than maintaining total Se levels in major organs of juvenile white sturgeon.</description><subject>Acipenser</subject><subject>Acipenser transmontanus</subject><subject>Agnatha. Pisces</subject><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Applied ecology</subject><subject>Biological and medical sciences</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Effects of pollution and side effects of pesticides on vertebrates</subject><subject>Fishes - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Mercury - metabolism</subject><subject>Methylmercury</subject><subject>Methylmercury Compounds - toxicity</subject><subject>Se bioavailability</subject><subject>Se metabolism</subject><subject>Se speciation</subject><subject>Selenium - metabolism</subject><subject>Selenium Compounds - metabolism</subject><subject>Selenocompounds</subject><subject>Selenocysteine - analogs & derivatives</subject><subject>Selenocysteine - metabolism</subject><subject>Selenomethionine</subject><subject>Selenomethionine - metabolism</subject><subject>Tissue Distribution</subject><subject>Water Pollutants, Chemical - metabolism</subject><subject>Water Pollutants, Chemical - toxicity</subject><issn>0166-445X</issn><issn>1879-1514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV-L1DAUxYso7rj6EZS8COtDxyRN2_RJlsV_sOKLgm8hTW9n7tCms7nJ6nwgv6cZZtRHDYRA-N1zDvcUxXPB14KL5vVube-SjcuPteRCrblec64eFCuh264UtVAPi1XmmlKp-ttF8YRox_ORqntcXMhatLzumlXx85NFH_NFv2ERiRIwggk8ppnRHhwCsQEpBuxTxMUzS8yy_RLBR7QTG2AET8BmcFvrkWZmN1mOYv6J28M0Q3ApHFhOig7jgaFnu3SfDSZg37cYs19MYQNZ-ura4f6oFlgM1tO85Gg-0aunxaPRTgTPzu9l8fXd2y83H8rbz-8_3lzflk51KpaSt5VuqrHqK1UNfeW0bLSCWgg59s2oW9vVlRRtK5peNlJUtdbS9dbWXIgGoLosrk66-7DcJaBoZiQH02Q9LImMaFSbd9jV3X-gsstuSrUZrU-oCwtRgNHsA842HIzg5lim2ZlzmeZYpuHa5DLz3IuzRepnGP5M_W4vAy_PgCVnpzHvzCH95bTWbVsdA7w5cZB3d48QDOVevYMBA7hohgX_EeUXNknEHA</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Huang, Susie Shih-Yin</creator><creator>Hung, Silas S.O.</creator><creator>Chan, Hing Man</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QH</scope><scope>7ST</scope><scope>7TV</scope><scope>7U6</scope><scope>7U7</scope><scope>7UA</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>SOI</scope></search><sort><creationdate>20141101</creationdate><title>Maintaining tissue selenium species distribution as a potential defense mechanism against methylmercury toxicity in juvenile white sturgeon (Acipenser transmontanus)</title><author>Huang, Susie Shih-Yin ; Hung, Silas S.O. ; Chan, Hing Man</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-2073863f3b343db3c82684e5112fb6f87a953217716b262135882cbaa50116ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acipenser</topic><topic>Acipenser transmontanus</topic><topic>Agnatha. Pisces</topic><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Applied ecology</topic><topic>Biological and medical sciences</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Effects of pollution and side effects of pesticides on vertebrates</topic><topic>Fishes - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Mercury - metabolism</topic><topic>Methylmercury</topic><topic>Methylmercury Compounds - toxicity</topic><topic>Se bioavailability</topic><topic>Se metabolism</topic><topic>Se speciation</topic><topic>Selenium - metabolism</topic><topic>Selenium Compounds - metabolism</topic><topic>Selenocompounds</topic><topic>Selenocysteine - analogs & derivatives</topic><topic>Selenocysteine - metabolism</topic><topic>Selenomethionine</topic><topic>Selenomethionine - metabolism</topic><topic>Tissue Distribution</topic><topic>Water Pollutants, Chemical - metabolism</topic><topic>Water Pollutants, Chemical - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Susie Shih-Yin</creatorcontrib><creatorcontrib>Hung, Silas S.O.</creatorcontrib><creatorcontrib>Chan, Hing Man</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Aqualine</collection><collection>Environment Abstracts</collection><collection>Pollution Abstracts</collection><collection>Sustainability Science Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Environment Abstracts</collection><jtitle>Aquatic toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Susie Shih-Yin</au><au>Hung, Silas S.O.</au><au>Chan, Hing Man</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maintaining tissue selenium species distribution as a potential defense mechanism against methylmercury toxicity in juvenile white sturgeon (Acipenser transmontanus)</atitle><jtitle>Aquatic toxicology</jtitle><addtitle>Aquat Toxicol</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>156</volume><spage>88</spage><epage>95</epage><pages>88-95</pages><issn>0166-445X</issn><eissn>1879-1514</eissn><coden>AQTODG</coden><abstract>•MeHg exposure mobilized endogenous Se from storage.•Co-exposure to MeHg increased de novo synthesis of biologically active Se forms in most tissues.•MeHg exposure resulted in transformation of the exogenous SeMet in the liver.•Selenocompound distribution in the kidneys was not affected by the exposure to MeHg.•When exposed to MeHg, maintaining levels of certain Se species is more important than total [Se].
Selenium (Se) has been shown to antagonize mercury (Hg) toxicity. We have previously demonstrated that orally intubated selenomethionine (SeMet) and methylmercury (MeHg) reduced tissue Se accumulation, as well as blood and kidney Hg concentrations in juvenile white sturgeon (Acipenser transmontanus). However, the form of Se accumulated is not known. In this study, three organoseleniums: selenocysteine (Sec), Se-methyl-selenocysteine (MSeCys), and SeMet and two inorganic Se species: selenate and selenite were determined and quantified in the blood at different post-intubation periods (12, 24, 48h) and in the muscle, liver, and kidneys at 48h in white sturgeon orally intubated with a single dose of control (carrier), SeMet (500μg Se/kg body weight; BW), MeHg (850μg Hg/kg BW), and both (Se+Hg; at 500μg Se/kg and 850μg Hg/kg BW). When only SeMet was intubated, the accumulative/unmodified pathway took precedent in the blood, white muscle, liver, and kidneys. In the presence of MeHg, however, active metabolic transformation and de novo synthesis of biologically active Se forms are seen in the liver and kidneys, as indicated by a gradual increase in blood Sec:SeMet ratios and Se metabolites. In the white muscle, mobilization of endogenous Se storage by MeHg is supported by the absence of tissue SeMet and detectable levels of blood SeMet. In contrast, co-intubation with SeMet increased muscle SeMet. The high levels of unknown Se metabolites and detectable levels of selenite in the kidney reflect its role as the major excretory organ for Se. Selenium metabolism is highly regulated in the kidneys, as Se speciation was not affected by MeHg or by its co-intubation with SeMet. In the Se+Hg group, the proportion of SeMet in the liver has decreased to nearly 1/8th of that of the SeMet only group, resulting in a more similar selenocompound distribution profile to that of the MeHg only group. This is likely due to the increased need for Se metabolites necessary for MeHg demethylation in the liver. Our study demonstrated that in the presence of MeHg, regulating tissue Se speciation, hence, Se bioavailability, is more an important strategy than maintaining total Se levels in major organs of juvenile white sturgeon.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>25170596</pmid><doi>10.1016/j.aquatox.2014.08.004</doi><tpages>8</tpages></addata></record> |
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subjects | Acipenser Acipenser transmontanus Agnatha. Pisces Animal, plant and microbial ecology Animals Applied ecology Biological and medical sciences Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates Fishes - metabolism Fundamental and applied biological sciences. Psychology Kidney - drug effects Kidney - metabolism Liver - drug effects Liver - metabolism Mercury - metabolism Methylmercury Methylmercury Compounds - toxicity Se bioavailability Se metabolism Se speciation Selenium - metabolism Selenium Compounds - metabolism Selenocompounds Selenocysteine - analogs & derivatives Selenocysteine - metabolism Selenomethionine Selenomethionine - metabolism Tissue Distribution Water Pollutants, Chemical - metabolism Water Pollutants, Chemical - toxicity |
title | Maintaining tissue selenium species distribution as a potential defense mechanism against methylmercury toxicity in juvenile white sturgeon (Acipenser transmontanus) |
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