Effects of green tea and physical exercise on memory impairments associated with aging
•Age-related memory deficits were verified in 9-month rats.•Physical exercise avoids biochemical parameters alterations and memory deficits.•Green tea does not reverse memory deficits associated with aging.•Green tea significantly decreases ROS activity and improve antioxidants defenses. We investig...
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| Veröffentlicht in: | Neurochemistry international 2014-12, Vol.78, p.53-60 |
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| container_title | Neurochemistry international |
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| creator | Flôres, Maíra F. Martins, Alexandre Schimidt, Helen L. Santos, Francielli W. Izquierdo, Iván Mello-Carpes, Pâmela B. Carpes, Felipe P. |
| description | •Age-related memory deficits were verified in 9-month rats.•Physical exercise avoids biochemical parameters alterations and memory deficits.•Green tea does not reverse memory deficits associated with aging.•Green tea significantly decreases ROS activity and improve antioxidants defenses.
We investigated the effects of physical exercise and green tea supplementation (associated or not) on biochemical and behavioral parameters in the time course of normal aging. Male Wistar rats aged 9months were divided into groups: control, physical exercise (treadmill running), and supplemented with green tea while either performing physical exercise or not. A young control group was also studied. Physical exercise and green tea supplementation lasted 3months. Afterwards, behavioral and biochemical tests were performed. Biochemical measurements revealed differences in antioxidant and oxidant responses in hippocampus, prefrontal cortex and striatum. Behavioral testing showed age-related memory impairments reversed by physical exercise. The association of green tea supplementation and physical exercise did not provide aged rats with additional improvements in memory or brain oxidative markers. Green tea per se significantly decreased reactive oxygen species levels and improved antioxidant defenses although it did not reverse memory deficits associated with normal aging. |
| doi_str_mv | 10.1016/j.neuint.2014.08.008 |
| format | Article |
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We investigated the effects of physical exercise and green tea supplementation (associated or not) on biochemical and behavioral parameters in the time course of normal aging. Male Wistar rats aged 9months were divided into groups: control, physical exercise (treadmill running), and supplemented with green tea while either performing physical exercise or not. A young control group was also studied. Physical exercise and green tea supplementation lasted 3months. Afterwards, behavioral and biochemical tests were performed. Biochemical measurements revealed differences in antioxidant and oxidant responses in hippocampus, prefrontal cortex and striatum. Behavioral testing showed age-related memory impairments reversed by physical exercise. The association of green tea supplementation and physical exercise did not provide aged rats with additional improvements in memory or brain oxidative markers. Green tea per se significantly decreased reactive oxygen species levels and improved antioxidant defenses although it did not reverse memory deficits associated with normal aging.</description><identifier>ISSN: 0197-0186</identifier><identifier>EISSN: 1872-9754</identifier><identifier>DOI: 10.1016/j.neuint.2014.08.008</identifier><identifier>PMID: 25195719</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Aging - metabolism ; Aging - psychology ; Animals ; Antioxidants ; Antioxidants - metabolism ; Brain ; Hippocampus ; Male ; Memory Disorders - metabolism ; Memory Disorders - prevention & control ; Memory Disorders - psychology ; Oxidative stress ; Physical Conditioning, Animal - methods ; Physical Conditioning, Animal - physiology ; Physical Conditioning, Animal - psychology ; Rats ; Rats, Wistar ; Tea ; Treadmill running ; Treatment Outcome</subject><ispartof>Neurochemistry international, 2014-12, Vol.78, p.53-60</ispartof><rights>2014 Elsevier Ltd</rights><rights>Copyright © 2014 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-ba3663796b2a7fb0ffe4f8a32c64485233ff6129eb0e09c8581906e5d2bf16f43</citedby><cites>FETCH-LOGICAL-c441t-ba3663796b2a7fb0ffe4f8a32c64485233ff6129eb0e09c8581906e5d2bf16f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neuint.2014.08.008$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25195719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Flôres, Maíra F.</creatorcontrib><creatorcontrib>Martins, Alexandre</creatorcontrib><creatorcontrib>Schimidt, Helen L.</creatorcontrib><creatorcontrib>Santos, Francielli W.</creatorcontrib><creatorcontrib>Izquierdo, Iván</creatorcontrib><creatorcontrib>Mello-Carpes, Pâmela B.</creatorcontrib><creatorcontrib>Carpes, Felipe P.</creatorcontrib><title>Effects of green tea and physical exercise on memory impairments associated with aging</title><title>Neurochemistry international</title><addtitle>Neurochem Int</addtitle><description>•Age-related memory deficits were verified in 9-month rats.•Physical exercise avoids biochemical parameters alterations and memory deficits.•Green tea does not reverse memory deficits associated with aging.•Green tea significantly decreases ROS activity and improve antioxidants defenses.
We investigated the effects of physical exercise and green tea supplementation (associated or not) on biochemical and behavioral parameters in the time course of normal aging. Male Wistar rats aged 9months were divided into groups: control, physical exercise (treadmill running), and supplemented with green tea while either performing physical exercise or not. A young control group was also studied. Physical exercise and green tea supplementation lasted 3months. Afterwards, behavioral and biochemical tests were performed. Biochemical measurements revealed differences in antioxidant and oxidant responses in hippocampus, prefrontal cortex and striatum. Behavioral testing showed age-related memory impairments reversed by physical exercise. The association of green tea supplementation and physical exercise did not provide aged rats with additional improvements in memory or brain oxidative markers. Green tea per se significantly decreased reactive oxygen species levels and improved antioxidant defenses although it did not reverse memory deficits associated with normal aging.</description><subject>Aging - metabolism</subject><subject>Aging - psychology</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Brain</subject><subject>Hippocampus</subject><subject>Male</subject><subject>Memory Disorders - metabolism</subject><subject>Memory Disorders - prevention & control</subject><subject>Memory Disorders - psychology</subject><subject>Oxidative stress</subject><subject>Physical Conditioning, Animal - methods</subject><subject>Physical Conditioning, Animal - physiology</subject><subject>Physical Conditioning, Animal - psychology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Tea</subject><subject>Treadmill running</subject><subject>Treatment Outcome</subject><issn>0197-0186</issn><issn>1872-9754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFu1DAQhi1URJfCGyDkYy8JM47j2JdKVVWgUiUuwNVynPHWq42z2NmWfXtSbdtjxWku3z__6BvGPiHUCKi-bOpE-5jmWgDKGnQNoN-wFepOVKZr5QlbAZquAtTqlL0vZQMAnYH2HTsVLZq2Q7Niv69DID8XPgW-zkSJz-S4SwPf3R1K9G7L6S9lHwvxKfGRxikfeBx3LuaR0hJ0pUw-upkG_hDnO-7WMa0_sLfBbQt9fJpn7NfX659X36vbH99uri5vKy8lzlXvGqWazqheuC70sNwig3aN8EpK3YqmCUGhMNQDgfG61WhAUTuIPqAKsjlj58e9uzz92VOZ7RiLp-3WJZr2xaKSHQAKDf-BCtNqZTQuqDyiPk-lZAp2l-Po8sEi2Ef5dmOP8u2jfAvaLvKX2Oenhn0_0vASera9ABdHgBYl95GyLT5S8jTEvDzBDlN8veEfnEOXfA</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Flôres, Maíra F.</creator><creator>Martins, Alexandre</creator><creator>Schimidt, Helen L.</creator><creator>Santos, Francielli W.</creator><creator>Izquierdo, Iván</creator><creator>Mello-Carpes, Pâmela B.</creator><creator>Carpes, Felipe P.</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20141201</creationdate><title>Effects of green tea and physical exercise on memory impairments associated with aging</title><author>Flôres, Maíra F. ; Martins, Alexandre ; Schimidt, Helen L. ; Santos, Francielli W. ; Izquierdo, Iván ; Mello-Carpes, Pâmela B. ; Carpes, Felipe P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-ba3663796b2a7fb0ffe4f8a32c64485233ff6129eb0e09c8581906e5d2bf16f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aging - metabolism</topic><topic>Aging - psychology</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Brain</topic><topic>Hippocampus</topic><topic>Male</topic><topic>Memory Disorders - metabolism</topic><topic>Memory Disorders - prevention & control</topic><topic>Memory Disorders - psychology</topic><topic>Oxidative stress</topic><topic>Physical Conditioning, Animal - methods</topic><topic>Physical Conditioning, Animal - physiology</topic><topic>Physical Conditioning, Animal - psychology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Tea</topic><topic>Treadmill running</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Flôres, Maíra F.</creatorcontrib><creatorcontrib>Martins, Alexandre</creatorcontrib><creatorcontrib>Schimidt, Helen L.</creatorcontrib><creatorcontrib>Santos, Francielli W.</creatorcontrib><creatorcontrib>Izquierdo, Iván</creatorcontrib><creatorcontrib>Mello-Carpes, Pâmela B.</creatorcontrib><creatorcontrib>Carpes, Felipe P.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neurochemistry international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Flôres, Maíra F.</au><au>Martins, Alexandre</au><au>Schimidt, Helen L.</au><au>Santos, Francielli W.</au><au>Izquierdo, Iván</au><au>Mello-Carpes, Pâmela B.</au><au>Carpes, Felipe P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of green tea and physical exercise on memory impairments associated with aging</atitle><jtitle>Neurochemistry international</jtitle><addtitle>Neurochem Int</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>78</volume><spage>53</spage><epage>60</epage><pages>53-60</pages><issn>0197-0186</issn><eissn>1872-9754</eissn><abstract>•Age-related memory deficits were verified in 9-month rats.•Physical exercise avoids biochemical parameters alterations and memory deficits.•Green tea does not reverse memory deficits associated with aging.•Green tea significantly decreases ROS activity and improve antioxidants defenses.
We investigated the effects of physical exercise and green tea supplementation (associated or not) on biochemical and behavioral parameters in the time course of normal aging. Male Wistar rats aged 9months were divided into groups: control, physical exercise (treadmill running), and supplemented with green tea while either performing physical exercise or not. A young control group was also studied. Physical exercise and green tea supplementation lasted 3months. Afterwards, behavioral and biochemical tests were performed. Biochemical measurements revealed differences in antioxidant and oxidant responses in hippocampus, prefrontal cortex and striatum. Behavioral testing showed age-related memory impairments reversed by physical exercise. The association of green tea supplementation and physical exercise did not provide aged rats with additional improvements in memory or brain oxidative markers. Green tea per se significantly decreased reactive oxygen species levels and improved antioxidant defenses although it did not reverse memory deficits associated with normal aging.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>25195719</pmid><doi>10.1016/j.neuint.2014.08.008</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Aging - metabolism Aging - psychology Animals Antioxidants Antioxidants - metabolism Brain Hippocampus Male Memory Disorders - metabolism Memory Disorders - prevention & control Memory Disorders - psychology Oxidative stress Physical Conditioning, Animal - methods Physical Conditioning, Animal - physiology Physical Conditioning, Animal - psychology Rats Rats, Wistar Tea Treadmill running Treatment Outcome |
| title | Effects of green tea and physical exercise on memory impairments associated with aging |
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