Antidepressant-like effects of aqueous extract from Cecropia pachystachya leaves in a mouse model of chronic unpredictable stress

Graphical abstract Aqueous extract of C. pachystachya leaves, produced a significant antidepressant-like response and was capable to prevent both the depression-like behaviour and the oxidative damage induced by chronic stress in mice, indicating that this plant could play an attractive tool for the...

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Veröffentlicht in:	Brain research bulletin 2014-09, Vol.108, p.10-17
Hauptverfasser:	Gazal, Marta, Ortmann, Caroline Flach, Martins, Fernanda Amelia, Streck, Emilio Luiz, Quevedo, João, de Campos, Angela Machado, Stefanello, Francieli M, Kaster, Manuella P, Ghisleni, Gabriele, Reginatto, Flávio Henrique, Lencina, Claiton L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressant activity Antidepressive Agents - administration & dosage Antidepressive Agents - pharmacology Antioxidant Anxiety - prevention & control Cecropia Cecropia pachystachya Cecropia Plant Chronic Disease Depression - prevention & control Disease Models, Animal Male Mice Motor Activity - drug effects Neurology Plant Extracts - administration & dosage Plant Extracts - pharmacology Stress, Psychological - prevention & control
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Zusammenfassung:	Graphical abstract Aqueous extract of C. pachystachya leaves, produced a significant antidepressant-like response and was capable to prevent both the depression-like behaviour and the oxidative damage induced by chronic stress in mice, indicating that this plant could play an attractive tool for the treatment of depressive disorders.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2014.07.007