Chronic toxicity and carcinogenicity of semicarbazide hydrochloride in Wistar Hannover GALAS rats

•Toxicological effects of chronic exposure to SEM-HCl were found in the bone, cartilage, and aorta.•The NOAEL in the present study was 10ppm in males and 50ppm in females.•SEM-HCl was not carcinogenic in male or female rats. We performed a combined study to determine the chronic toxicity and carcino...

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