Effects of RU 52583, an alpha 2-antagonist, on memory in rats with excitotoxic damage to the septal area

The anti-amnesic action of RU 52583, an alpha 2-adrenergic receptor antagonist, was evaluated through performance of spatial tasks in a radial maze by rats with N-methyl-D-aspartic acid (NMDA) lesion of the medial septal (MS) nuclei. Memory performance of lesioned or sham-operated rats was evaluated...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1997-04, Vol.56 (4), p.649-655
Hauptverfasser:	M'Harzi, M, Willig, F, Bardelay, C, Palou, A M, Oberlander, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-2 Receptor Antagonists Adrenergic alpha-Antagonists - pharmacology Animals Choline - metabolism Cholinesterase Inhibitors - pharmacology Excitatory Amino Acid Agonists - toxicity Hippocampus - metabolism Hippocampus - physiology Idazoxan - pharmacology Male Maze Learning - drug effects Memory - drug effects Muscarinic Agonists - pharmacology N-Methylaspartate - toxicity Physostigmine - pharmacology Rats Septal Nuclei - drug effects Theta Rhythm - drug effects Vinca Alkaloids - pharmacology
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