The novel metabotropic glutamate receptor agonist 2R,4R-APDC potentiates stimulation of phosphoinositide hydrolysis in the rat hippocampus by 3,5-dihydroxyphenylglycine : Evidence for a synergistic interaction between group 1 and group 2 receptors

The mGlu receptor subtypes and second messenger pathways that mediate 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) responses in brain tissues are not fully understood. 1S,3R-ACPD differs from 3,5-dihydroxyphenylglycine (DHPG) or quisqualate in that 1S,3R-ACPD also activates group 2 m...

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Veröffentlicht in:	Neuropharmacology 1996-01, Vol.35 (12), p.1661-1672
Hauptverfasser:	SCHOEPP, D. D, SALHOFF, C. R, WRIGHT, R. A, JOHNSON, B. G, BURNETT, J. P, MAYNE, N. G, BELAGAJE, R, WU, S, MONN, J. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Animals Animals, Newborn Biological and medical sciences Brain - physiology Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cloning, Molecular Colforsin - pharmacology Cyclic AMP - metabolism Cycloleucine - analogs & derivatives Cycloleucine - pharmacology Drug Synergism Excitatory Amino Acid Agonists - pharmacology Excitatory Amino Acid Antagonists - pharmacology Fundamental and applied biological sciences. Psychology Glycine - analogs & derivatives Glycine - pharmacology Hippocampus - drug effects Hippocampus - physiology Humans Inositol - metabolism Kinetics Neuroprotective Agents - pharmacology Phosphatidylinositols - metabolism Proline - analogs & derivatives Proline - pharmacology Quisqualic Acid - pharmacology Rats Receptors, Metabotropic Glutamate - drug effects Receptors, Metabotropic Glutamate - physiology Recombinant Proteins - drug effects Recombinant Proteins - metabolism Resorcinols - pharmacology Second Messenger Systems Vertebrates: nervous system and sense organs
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