Synaptosomal uptake of alpha-ketoglutarate and glutamine in thioacetamide-induced hepatic encephalopathy in rats

The kinetics of uptake of two astroglia-derived glutamate (GLU) precursors, alpha-ketoglutarate (alpha-KG) and glutamine (GLN) were determined in synaptosomes derived from rats with acute hepatic encephalopathy (HE) induced with a hepatotoxin, thioacetamide (TAA). TAA treatment increased by 33% Vmax...

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Veröffentlicht in:	Metabolic brain disease 1997-12, Vol.12 (4), p.281-286
Hauptverfasser:	ALBRECHT, J, WASKIEWICZ, J, DOLINSKA, M, RAFALOWSKA, U
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Gastroenterology. Liver. Pancreas. Abdomen Glutamine - pharmacokinetics Hepatic Encephalopathy - chemically induced Hepatic Encephalopathy - metabolism Ketoglutaric Acids - pharmacokinetics Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Other diseases. Semiology Rats Rats, Wistar Synaptosomes - metabolism Thioacetamide - toxicity
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