A Y-box consensus sequence is required for basal expression of the human multidrug resistance (mdr1) gene

Basal transcription of the human multidrug resistance (mdr1) promoter was studied by chloramphenicol acetyltransferase (CAT) reporter fusion gene analysis in two parental and doxorubicin-resistant human tumor cell lines. Deletion of mdr1 DNA sequences to -89 relative to the start of transcription (a...

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Veröffentlicht in:	The Journal of biological chemistry 1993-03, Vol.268 (8), p.5856-5860
Hauptverfasser:	GOLDSMITH, M. E, MADDEN, M. J, MORROW, C. S, COWAN, K. H
Format:	Artikel
Sprache:	eng
Schlagworte:	ATP Binding Cassette Transporter, Subfamily B, Member 1 Base Sequence Biological and medical sciences Chloramphenicol O-Acetyltransferase - genetics Consensus Sequence DNA Doxorubicin - pharmacology Drug Resistance - genetics Fundamental and applied biological sciences. Psychology Gene Expression Humans Membrane Glycoproteins - genetics Molecular and cellular biology Molecular genetics Molecular Sequence Data Promoter Regions, Genetic Sequence Deletion Transcription, Genetic Transcription. Transcription factor. Splicing. Rna processing Tumor Cells, Cultured
Online-Zugang:	Volltext
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