Significance of IMP3, Nucleophosmin, and Ki-67 Expression in Papillary Thyroid Carcinoma
The purpose of our study was to investigate the diagnostic value of expression of IMP3, nucleophosmin, and correlation of these markers with Ki-67 proliferation index in papillary thyroid carcinoma and benign neoplasms of thyroid gland. The aim was also to investigate whether there is a difference b...
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| Veröffentlicht in: | International journal of surgical pathology 2015-02, Vol.23 (1), p.5-12 |
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| container_title | International journal of surgical pathology |
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| creator | Yorukoglu, Aygun Yalcin, Nagihan Avci, Arzu Cakalagaoglu, Fulya Yaylali, Guzin Akin, Fulya Haciyanli, Mehmet Ozden, Akin |
| description | The purpose of our study was to investigate the diagnostic value of expression of IMP3, nucleophosmin, and correlation of these markers with Ki-67 proliferation index in papillary thyroid carcinoma and benign neoplasms of thyroid gland. The aim was also to investigate whether there is a difference between papillary and micropapillary carcinomas with regard to clinicopathologic parameters beside IMP3, nucleophosmin, and Ki-67 proliferation index. It was concluded that IMP3 and nucleophosmin cannot be a routine diagnostic marker for discrimination of papillary carcinomas and benign lesions. IMP3 positive staining was quite scarce in IMP3 positive papillary carcinomas although specifity of IMP3 is 100%. A statistically significant correlation was not detected between nucleophosmin, IMP-3, and Ki-67 proliferation index. A statistically significant correlation was found between tumor size, lymphovascular embolism, and Ki-67 proliferation index. There was also significant correlation between tumor size and lymphovascular embolism. |
| doi_str_mv | 10.1177/1066896914554832 |
| format | Article |
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The aim was also to investigate whether there is a difference between papillary and micropapillary carcinomas with regard to clinicopathologic parameters beside IMP3, nucleophosmin, and Ki-67 proliferation index. It was concluded that IMP3 and nucleophosmin cannot be a routine diagnostic marker for discrimination of papillary carcinomas and benign lesions. IMP3 positive staining was quite scarce in IMP3 positive papillary carcinomas although specifity of IMP3 is 100%. A statistically significant correlation was not detected between nucleophosmin, IMP-3, and Ki-67 proliferation index. A statistically significant correlation was found between tumor size, lymphovascular embolism, and Ki-67 proliferation index. There was also significant correlation between tumor size and lymphovascular embolism.</description><identifier>ISSN: 1066-8969</identifier><identifier>EISSN: 1940-2465</identifier><identifier>DOI: 10.1177/1066896914554832</identifier><identifier>PMID: 25389240</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - metabolism ; Carcinoma, Papillary - diagnosis ; Carcinoma, Papillary - metabolism ; Carcinoma, Papillary - pathology ; Cell Proliferation ; Diagnosis, Differential ; Female ; Goiter, Nodular - diagnosis ; Goiter, Nodular - metabolism ; Goiter, Nodular - pathology ; Humans ; Ki-67 Antigen - metabolism ; Male ; Middle Aged ; Nuclear Proteins - metabolism ; RNA-Binding Proteins - metabolism ; Sensitivity and Specificity ; Thyroid Gland - metabolism ; Thyroid Gland - pathology ; Thyroid Neoplasms - diagnosis ; Thyroid Neoplasms - metabolism ; Thyroid Neoplasms - pathology ; Thyroiditis - diagnosis ; Thyroiditis - metabolism ; Thyroiditis - pathology ; Young Adult</subject><ispartof>International journal of surgical pathology, 2015-02, Vol.23 (1), p.5-12</ispartof><rights>The Author(s) 2014</rights><rights>The Author(s) 2014.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-240d3b6b178eba4a53eb645000c725253b475ef1eea227332dfb2f416aaa68f33</citedby><cites>FETCH-LOGICAL-c337t-240d3b6b178eba4a53eb645000c725253b475ef1eea227332dfb2f416aaa68f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1066896914554832$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1066896914554832$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25389240$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yorukoglu, Aygun</creatorcontrib><creatorcontrib>Yalcin, Nagihan</creatorcontrib><creatorcontrib>Avci, Arzu</creatorcontrib><creatorcontrib>Cakalagaoglu, Fulya</creatorcontrib><creatorcontrib>Yaylali, Guzin</creatorcontrib><creatorcontrib>Akin, Fulya</creatorcontrib><creatorcontrib>Haciyanli, Mehmet</creatorcontrib><creatorcontrib>Ozden, Akin</creatorcontrib><title>Significance of IMP3, Nucleophosmin, and Ki-67 Expression in Papillary Thyroid Carcinoma</title><title>International journal of surgical pathology</title><addtitle>Int J Surg Pathol</addtitle><description>The purpose of our study was to investigate the diagnostic value of expression of IMP3, nucleophosmin, and correlation of these markers with Ki-67 proliferation index in papillary thyroid carcinoma and benign neoplasms of thyroid gland. The aim was also to investigate whether there is a difference between papillary and micropapillary carcinomas with regard to clinicopathologic parameters beside IMP3, nucleophosmin, and Ki-67 proliferation index. It was concluded that IMP3 and nucleophosmin cannot be a routine diagnostic marker for discrimination of papillary carcinomas and benign lesions. IMP3 positive staining was quite scarce in IMP3 positive papillary carcinomas although specifity of IMP3 is 100%. A statistically significant correlation was not detected between nucleophosmin, IMP-3, and Ki-67 proliferation index. A statistically significant correlation was found between tumor size, lymphovascular embolism, and Ki-67 proliferation index. There was also significant correlation between tumor size and lymphovascular embolism.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Carcinoma, Papillary - diagnosis</subject><subject>Carcinoma, Papillary - metabolism</subject><subject>Carcinoma, Papillary - pathology</subject><subject>Cell Proliferation</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Goiter, Nodular - diagnosis</subject><subject>Goiter, Nodular - metabolism</subject><subject>Goiter, Nodular - pathology</subject><subject>Humans</subject><subject>Ki-67 Antigen - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nuclear Proteins - metabolism</subject><subject>RNA-Binding Proteins - metabolism</subject><subject>Sensitivity and Specificity</subject><subject>Thyroid Gland - metabolism</subject><subject>Thyroid Gland - pathology</subject><subject>Thyroid Neoplasms - diagnosis</subject><subject>Thyroid Neoplasms - metabolism</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroiditis - diagnosis</subject><subject>Thyroiditis - metabolism</subject><subject>Thyroiditis - pathology</subject><subject>Young Adult</subject><issn>1066-8969</issn><issn>1940-2465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1LAzEQxYMotlbvniRHD13N1ybbo5SqxaoFK3hbstlsm7KbrEkX7H9vSqsHwdMMzHuP3zwALjG6wViIW4w4z0Z8hFmasoySI9DHI4YSwnh6HPd4Tnb3HjgLYY0QIpzgU9AjKc1GhKE--HgzS2sqo6RVGroKTp_ndAhfOlVr165caIwdQmlL-GQSLuDkq_U6BOMsNBbOZWvqWvotXKy23pkSjqVXxrpGnoOTStZBXxzmALzfTxbjx2T2-jAd380SRanYRFJU0oIXWGS6kEymVBecpRFVCZJGzoKJVFdYa0mIoJSUVUEqhrmUkmcVpQNwvc9tvfvsdNjkjQlKRyqrXRdyHNNEhgVHUYr2UuVdCF5XeetNE-lzjPJdn_nfPqPl6pDeFY0ufw0_BUZBshcEudT52nXexm__D_wGfsd7Zw</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Yorukoglu, Aygun</creator><creator>Yalcin, Nagihan</creator><creator>Avci, Arzu</creator><creator>Cakalagaoglu, Fulya</creator><creator>Yaylali, Guzin</creator><creator>Akin, Fulya</creator><creator>Haciyanli, Mehmet</creator><creator>Ozden, Akin</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150201</creationdate><title>Significance of IMP3, Nucleophosmin, and Ki-67 Expression in Papillary Thyroid Carcinoma</title><author>Yorukoglu, Aygun ; Yalcin, Nagihan ; Avci, Arzu ; Cakalagaoglu, Fulya ; Yaylali, Guzin ; Akin, Fulya ; Haciyanli, Mehmet ; Ozden, Akin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-240d3b6b178eba4a53eb645000c725253b475ef1eea227332dfb2f416aaa68f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Carcinoma, Papillary - diagnosis</topic><topic>Carcinoma, Papillary - metabolism</topic><topic>Carcinoma, Papillary - pathology</topic><topic>Cell Proliferation</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Goiter, Nodular - diagnosis</topic><topic>Goiter, Nodular - metabolism</topic><topic>Goiter, Nodular - pathology</topic><topic>Humans</topic><topic>Ki-67 Antigen - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nuclear Proteins - metabolism</topic><topic>RNA-Binding Proteins - metabolism</topic><topic>Sensitivity and Specificity</topic><topic>Thyroid Gland - metabolism</topic><topic>Thyroid Gland - pathology</topic><topic>Thyroid Neoplasms - diagnosis</topic><topic>Thyroid Neoplasms - metabolism</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroiditis - diagnosis</topic><topic>Thyroiditis - metabolism</topic><topic>Thyroiditis - pathology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yorukoglu, Aygun</creatorcontrib><creatorcontrib>Yalcin, Nagihan</creatorcontrib><creatorcontrib>Avci, Arzu</creatorcontrib><creatorcontrib>Cakalagaoglu, Fulya</creatorcontrib><creatorcontrib>Yaylali, Guzin</creatorcontrib><creatorcontrib>Akin, Fulya</creatorcontrib><creatorcontrib>Haciyanli, Mehmet</creatorcontrib><creatorcontrib>Ozden, Akin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of surgical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yorukoglu, Aygun</au><au>Yalcin, Nagihan</au><au>Avci, Arzu</au><au>Cakalagaoglu, Fulya</au><au>Yaylali, Guzin</au><au>Akin, Fulya</au><au>Haciyanli, Mehmet</au><au>Ozden, Akin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Significance of IMP3, Nucleophosmin, and Ki-67 Expression in Papillary Thyroid Carcinoma</atitle><jtitle>International journal of surgical pathology</jtitle><addtitle>Int J Surg Pathol</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>23</volume><issue>1</issue><spage>5</spage><epage>12</epage><pages>5-12</pages><issn>1066-8969</issn><eissn>1940-2465</eissn><abstract>The purpose of our study was to investigate the diagnostic value of expression of IMP3, nucleophosmin, and correlation of these markers with Ki-67 proliferation index in papillary thyroid carcinoma and benign neoplasms of thyroid gland. The aim was also to investigate whether there is a difference between papillary and micropapillary carcinomas with regard to clinicopathologic parameters beside IMP3, nucleophosmin, and Ki-67 proliferation index. It was concluded that IMP3 and nucleophosmin cannot be a routine diagnostic marker for discrimination of papillary carcinomas and benign lesions. IMP3 positive staining was quite scarce in IMP3 positive papillary carcinomas although specifity of IMP3 is 100%. A statistically significant correlation was not detected between nucleophosmin, IMP-3, and Ki-67 proliferation index. A statistically significant correlation was found between tumor size, lymphovascular embolism, and Ki-67 proliferation index. There was also significant correlation between tumor size and lymphovascular embolism.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>25389240</pmid><doi>10.1177/1066896914554832</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Biomarkers, Tumor - metabolism Carcinoma, Papillary - diagnosis Carcinoma, Papillary - metabolism Carcinoma, Papillary - pathology Cell Proliferation Diagnosis, Differential Female Goiter, Nodular - diagnosis Goiter, Nodular - metabolism Goiter, Nodular - pathology Humans Ki-67 Antigen - metabolism Male Middle Aged Nuclear Proteins - metabolism RNA-Binding Proteins - metabolism Sensitivity and Specificity Thyroid Gland - metabolism Thyroid Gland - pathology Thyroid Neoplasms - diagnosis Thyroid Neoplasms - metabolism Thyroid Neoplasms - pathology Thyroiditis - diagnosis Thyroiditis - metabolism Thyroiditis - pathology Young Adult |
| title | Significance of IMP3, Nucleophosmin, and Ki-67 Expression in Papillary Thyroid Carcinoma |
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