Disputed rpoB mutations can frequently cause important rifampicin resistance among new tuberculosis patients

SETTING: Greater Mymensingh area, Bangladesh.OBJECTIVES: To document among new tuberculosis (TB) patients the proportions and treatment outcomes of silent, non-disputed and disputed (generally missed by rapid drug susceptibility testing [DST]) rpoB mutations, and their detection by commercial molecu...

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Veröffentlicht in:	The international journal of tuberculosis and lung disease 2015-02, Vol.19 (2), p.185-190
Hauptverfasser:	Van Deun, A., Aung, K. J. M., Hossain, A., de Rijk, P., Gumusboga, M., Rigouts, L., de Jong, B. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitubercular Agents - pharmacology Bacterial Proteins - genetics Bangladesh DNA-Directed RNA Polymerases Drug Resistance Drug Resistance, Bacterial Humans Microbial Sensitivity Tests Mutation Mycobacterium Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Nucleic Acid Amplification Techniques Retrospective Studies rifampicin Rifampin - pharmacology Rpob Gene Sputum - microbiology Surveillance Tuberculosis Tuberculosis - drug therapy Tuberculosis - microbiology
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