The biological response to a failed extra-articular polyester ligament used for AC Joint reconstruction at the shoulder girdle: a retrieval analysis of five cases
The LockDown device (previously called Surgilig) is a braided polyester mesh which is mostly used to reconstruct the dislocated acromioclavicular joint. More than 11,000 have been implanted worldwide. Little is known about the tissue reaction to the device nor to its wear products when implanted in...
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| Veröffentlicht in: | The bone & joint journal 2015-01, Vol.97-B (1), p.83-88 |
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| container_title | The bone & joint journal |
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| creator | Kocsis, G McCulloch, T A Thyagarajan, D Wallace, W A |
| description | The LockDown device (previously called Surgilig) is a braided polyester mesh which is mostly used to reconstruct the dislocated acromioclavicular joint. More than 11,000 have been implanted worldwide. Little is known about the tissue reaction to the device nor to its wear products when implanted in an extra-articular site in humans. This is of importance as an adverse immunological reaction could result in osteolysis or damage to the local tissues, thereby affecting the longevity of the implant. We analysed the histology of five LockDown implants retrieved from five patients over the last seven years by one of the senior authors. Routine analysis was carried out in all five cases and immunohistochemistry in one. The LockDown device acts as a scaffold for connective tissue which forms an investing fibrous pseudoligament. The immunological response at the histological level seems favourable with a limited histiocytic and giant cell response to micron-sized wear particles. The connective tissue envelope around the implant is less organised than a native ligament. |
| doi_str_mv | 10.1302/0301-620X.97B1.34357 |
| format | Article |
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More than 11,000 have been implanted worldwide. Little is known about the tissue reaction to the device nor to its wear products when implanted in an extra-articular site in humans. This is of importance as an adverse immunological reaction could result in osteolysis or damage to the local tissues, thereby affecting the longevity of the implant. We analysed the histology of five LockDown implants retrieved from five patients over the last seven years by one of the senior authors. Routine analysis was carried out in all five cases and immunohistochemistry in one. The LockDown device acts as a scaffold for connective tissue which forms an investing fibrous pseudoligament. The immunological response at the histological level seems favourable with a limited histiocytic and giant cell response to micron-sized wear particles. 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More than 11,000 have been implanted worldwide. Little is known about the tissue reaction to the device nor to its wear products when implanted in an extra-articular site in humans. This is of importance as an adverse immunological reaction could result in osteolysis or damage to the local tissues, thereby affecting the longevity of the implant. We analysed the histology of five LockDown implants retrieved from five patients over the last seven years by one of the senior authors. Routine analysis was carried out in all five cases and immunohistochemistry in one. The LockDown device acts as a scaffold for connective tissue which forms an investing fibrous pseudoligament. The immunological response at the histological level seems favourable with a limited histiocytic and giant cell response to micron-sized wear particles. The connective tissue envelope around the implant is less organised than a native ligament.</description><subject>Acromioclavicular Joint - physiopathology</subject><subject>Acromioclavicular Joint - surgery</subject><subject>Adult</subject><subject>Device Removal</subject><subject>Equipment Failure Analysis</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Joint Dislocations - surgery</subject><subject>Ligaments, Articular - surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polyesters - adverse effects</subject><subject>Prostheses and Implants</subject><subject>Prosthesis Failure</subject><subject>Reconstructive Surgical Procedures - adverse effects</subject><subject>Reconstructive Surgical Procedures - methods</subject><subject>Reoperation - methods</subject><subject>Sampling Studies</subject><subject>Sensitivity and Specificity</subject><issn>2049-4394</issn><issn>2049-4408</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kcFuFDEMhiMEolXpGyCUI5dZkkkyk3Arq0JBlbgUiVvkZpxtUHayJJmq-zo8KRna4ost6__9y_oIecvZhgvWf2CC8W7o2c-NGT_xjZBCjS_Iac-k6aRk-uXzLIw8Ieel_GKtNONc8tfkpFdq0JLrU_Ln5g7pbUgx7YKDSDOWQ5oL0pooUA8h4kTxoWboINfglgiZHlI8YqmYaQw72ONc6VKazqdML7b0Wwptk9G1QzUvroY0U6i0tqhyl5Y4Necu5CnixxaSseaA9y0cZojHEgpNnvpwj9RBwfKGvPIQC54_9TPy4_Plzfaqu_7-5ev24rpzfOS1M0xNggvd-4kBl70WOEll-tGJaZyEN0qDMEZCPwBoJwYDnAvugXHnGI7ijLx_vHvI6ffS_rP7UBzGCDOmpVg-SDWOWqlVKh-lLqdSMnp7yGEP-Wg5sysguwKyKyC7ArL_ADXbu6eE5XaP03_TMw7xF2OnjgQ</recordid><startdate>201501</startdate><enddate>201501</enddate><creator>Kocsis, G</creator><creator>McCulloch, T A</creator><creator>Thyagarajan, D</creator><creator>Wallace, W A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201501</creationdate><title>The biological response to a failed extra-articular polyester ligament used for AC Joint reconstruction at the shoulder girdle: a retrieval analysis of five cases</title><author>Kocsis, G ; McCulloch, T A ; Thyagarajan, D ; Wallace, W A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c171t-905d31382fd0a14283ed45927c3d7d3f958a3994a26aa8c369a1131fa01cc0e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acromioclavicular Joint - physiopathology</topic><topic>Acromioclavicular Joint - surgery</topic><topic>Adult</topic><topic>Device Removal</topic><topic>Equipment Failure Analysis</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Joint Dislocations - surgery</topic><topic>Ligaments, Articular - surgery</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polyesters - adverse effects</topic><topic>Prostheses and Implants</topic><topic>Prosthesis Failure</topic><topic>Reconstructive Surgical Procedures - adverse effects</topic><topic>Reconstructive Surgical Procedures - methods</topic><topic>Reoperation - methods</topic><topic>Sampling Studies</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kocsis, G</creatorcontrib><creatorcontrib>McCulloch, T A</creatorcontrib><creatorcontrib>Thyagarajan, D</creatorcontrib><creatorcontrib>Wallace, W A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The bone & joint journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kocsis, G</au><au>McCulloch, T A</au><au>Thyagarajan, D</au><au>Wallace, W A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The biological response to a failed extra-articular polyester ligament used for AC Joint reconstruction at the shoulder girdle: a retrieval analysis of five cases</atitle><jtitle>The bone & joint journal</jtitle><addtitle>Bone Joint J</addtitle><date>2015-01</date><risdate>2015</risdate><volume>97-B</volume><issue>1</issue><spage>83</spage><epage>88</epage><pages>83-88</pages><issn>2049-4394</issn><eissn>2049-4408</eissn><abstract>The LockDown device (previously called Surgilig) is a braided polyester mesh which is mostly used to reconstruct the dislocated acromioclavicular joint. More than 11,000 have been implanted worldwide. Little is known about the tissue reaction to the device nor to its wear products when implanted in an extra-articular site in humans. This is of importance as an adverse immunological reaction could result in osteolysis or damage to the local tissues, thereby affecting the longevity of the implant. We analysed the histology of five LockDown implants retrieved from five patients over the last seven years by one of the senior authors. Routine analysis was carried out in all five cases and immunohistochemistry in one. The LockDown device acts as a scaffold for connective tissue which forms an investing fibrous pseudoligament. The immunological response at the histological level seems favourable with a limited histiocytic and giant cell response to micron-sized wear particles. The connective tissue envelope around the implant is less organised than a native ligament.</abstract><cop>England</cop><pmid>25568418</pmid><doi>10.1302/0301-620X.97B1.34357</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | The bone & joint journal, 2015-01, Vol.97-B (1), p.83-88 |
| issn | 2049-4394 2049-4408 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Ovid Autoload; Alma/SFX Local Collection |
| subjects | Acromioclavicular Joint - physiopathology Acromioclavicular Joint - surgery Adult Device Removal Equipment Failure Analysis Female Humans Immunohistochemistry Joint Dislocations - surgery Ligaments, Articular - surgery Male Middle Aged Polyesters - adverse effects Prostheses and Implants Prosthesis Failure Reconstructive Surgical Procedures - adverse effects Reconstructive Surgical Procedures - methods Reoperation - methods Sampling Studies Sensitivity and Specificity |
| title | The biological response to a failed extra-articular polyester ligament used for AC Joint reconstruction at the shoulder girdle: a retrieval analysis of five cases |
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