Effect of External Magnetic Field on IV 99mTc-Labeled Aminosilane-Coated Iron Oxide Nanoparticles: Demonstration in a Rat Model: Special Report
ABSTRACTAmong the most interesting applications of ferromagnetic nanoparticles (NPs) in medicine is the potential for localizing pharmacologically or radioactively tagged agents directly to selected tissues selected by an adjustable external magnetic field. This concept is demonstrated by the applic...
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| Veröffentlicht in: | Clinical nuclear medicine 2015-02, Vol.40 (2), p.e104-e110 |
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| creator | Liberatore, Mauro Barteri, Mario Megna, Valentina D’Elia, Piera Rebonato, Stefania Latini, Augusto De Angelis, Francesca Scaramuzzo, Francesca Anna De Stefano, Maria Egle Guadagno, Noemi Antonella Chondrogiannis, Sotirios Maffione, Anna Margherita Rubello, Domenico Pala, Alessandro Colletti, Patrick M |
| description | ABSTRACTAmong the most interesting applications of ferromagnetic nanoparticles (NPs) in medicine is the potential for localizing pharmacologically or radioactively tagged agents directly to selected tissues selected by an adjustable external magnetic field. This concept is demonstrated by the application external magnetic field on IV Tc-labeled aminosilane-coated iron oxide NPs in a rat model. In a model comparing a rat with a 0.3-T magnet over a hind paw versus a rat without a magnet, a static acquisition at 45 minutes showed that 27% of the administered radioactivity was in the area subtended by the magnet, whereas the liver displays a percentage of binding of 14% in the presence of the magnet and of 16% in the absence of an external magnetic field. These preliminary results suggest that the application of an external magnetic field may be a viable route for the development of methods for the confinement of magnetic NPs labeled with radioactive isotopes targeted for predetermined sites of the body. |
| doi_str_mv | 10.1097/RLU.0000000000000672 |
| format | Article |
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These preliminary results suggest that the application of an external magnetic field may be a viable route for the development of methods for the confinement of magnetic NPs labeled with radioactive isotopes targeted for predetermined sites of the body.</description><identifier>ISSN: 0363-9762</identifier><identifier>EISSN: 1536-0229</identifier><identifier>DOI: 10.1097/RLU.0000000000000672</identifier><identifier>PMID: 25551623</identifier><language>eng</language><publisher>United States: by Lippincott Williams & Wilkins</publisher><subject>Animals ; Liver - drug effects ; Magnetic Fields ; Magnetite Nanoparticles ; Male ; Radiopharmaceuticals - administration & dosage ; Radiopharmaceuticals - pharmacokinetics ; Rats ; Silanes - chemistry ; Technetium - administration & dosage ; Technetium - pharmacokinetics ; Tissue Distribution</subject><ispartof>Clinical nuclear medicine, 2015-02, Vol.40 (2), p.e104-e110</ispartof><rights>2015 by Lippincott Williams & Wilkins</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2202-9379ff300130ab5ea67aba1b72646f5c5d8314cc883a2636682fcc760ce93bca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25551623$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liberatore, Mauro</creatorcontrib><creatorcontrib>Barteri, Mario</creatorcontrib><creatorcontrib>Megna, Valentina</creatorcontrib><creatorcontrib>D’Elia, Piera</creatorcontrib><creatorcontrib>Rebonato, Stefania</creatorcontrib><creatorcontrib>Latini, Augusto</creatorcontrib><creatorcontrib>De Angelis, Francesca</creatorcontrib><creatorcontrib>Scaramuzzo, Francesca Anna</creatorcontrib><creatorcontrib>De Stefano, Maria Egle</creatorcontrib><creatorcontrib>Guadagno, Noemi Antonella</creatorcontrib><creatorcontrib>Chondrogiannis, Sotirios</creatorcontrib><creatorcontrib>Maffione, Anna Margherita</creatorcontrib><creatorcontrib>Rubello, Domenico</creatorcontrib><creatorcontrib>Pala, Alessandro</creatorcontrib><creatorcontrib>Colletti, Patrick M</creatorcontrib><title>Effect of External Magnetic Field on IV 99mTc-Labeled Aminosilane-Coated Iron Oxide Nanoparticles: Demonstration in a Rat Model: Special Report</title><title>Clinical nuclear medicine</title><addtitle>Clin Nucl Med</addtitle><description>ABSTRACTAmong the most interesting applications of ferromagnetic nanoparticles (NPs) in medicine is the potential for localizing pharmacologically or radioactively tagged agents directly to selected tissues selected by an adjustable external magnetic field. 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These preliminary results suggest that the application of an external magnetic field may be a viable route for the development of methods for the confinement of magnetic NPs labeled with radioactive isotopes targeted for predetermined sites of the body.</description><subject>Animals</subject><subject>Liver - drug effects</subject><subject>Magnetic Fields</subject><subject>Magnetite Nanoparticles</subject><subject>Male</subject><subject>Radiopharmaceuticals - administration & dosage</subject><subject>Radiopharmaceuticals - pharmacokinetics</subject><subject>Rats</subject><subject>Silanes - chemistry</subject><subject>Technetium - administration & dosage</subject><subject>Technetium - pharmacokinetics</subject><subject>Tissue Distribution</subject><issn>0363-9762</issn><issn>1536-0229</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAQhi0EokvhDRDykUuKY2_suLdq2cJKWyotLddo4oypwYlT26uWp-CVcbUFIQ7MZaTRN_9o_p-Q1zU7qZlW73bb6xP2d0nFn5BF3QhZMc71U7JgQopKK8mPyIuUvjFWy1oun5Mj3jRNLblYkJ9ra9FkGixd32eME3h6AV8nzM7Qc4d-oGGimy9U6_HKVFvo0eNAz0Y3heQ8TFitAuQy2sQCXt67AeknmMIMsUh4TKf0PY5hSjlCdgVxEwW6g0wvwoD-lH6e0bhydYdziPkleWbBJ3z12I_J9fn6avWx2l5-2KzOtpXhnPFKC6WtFeUjwaBvEKSCHupecbmUtjHN0Ip6aUzbCuBSSNlya4ySzKAWvQFxTN4edOcYbveYcje6ZNA_fBT2qSs-NUq1jOmCLg-oiSGliLaboxsh_uhq1j1E0ZUoun-jKGtvHi_s-xGHP0u_vS9AewDugi_Op-9-f4exu0Hw-eb_2r8AJxKVFw</recordid><startdate>201502</startdate><enddate>201502</enddate><creator>Liberatore, Mauro</creator><creator>Barteri, Mario</creator><creator>Megna, Valentina</creator><creator>D’Elia, Piera</creator><creator>Rebonato, Stefania</creator><creator>Latini, Augusto</creator><creator>De Angelis, Francesca</creator><creator>Scaramuzzo, Francesca Anna</creator><creator>De Stefano, Maria Egle</creator><creator>Guadagno, Noemi Antonella</creator><creator>Chondrogiannis, Sotirios</creator><creator>Maffione, Anna Margherita</creator><creator>Rubello, Domenico</creator><creator>Pala, Alessandro</creator><creator>Colletti, Patrick M</creator><general>by Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201502</creationdate><title>Effect of External Magnetic Field on IV 99mTc-Labeled Aminosilane-Coated Iron Oxide Nanoparticles: Demonstration in a Rat Model: Special Report</title><author>Liberatore, Mauro ; 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| subjects | Animals Liver - drug effects Magnetic Fields Magnetite Nanoparticles Male Radiopharmaceuticals - administration & dosage Radiopharmaceuticals - pharmacokinetics Rats Silanes - chemistry Technetium - administration & dosage Technetium - pharmacokinetics Tissue Distribution |
| title | Effect of External Magnetic Field on IV 99mTc-Labeled Aminosilane-Coated Iron Oxide Nanoparticles: Demonstration in a Rat Model: Special Report |
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