Premature Ventricular Contraction Variability in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
PVC Variability in ARVD/C Introduction Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is an inherited cardiomyopathy, characterized by right ventricular dysfunction and ventricular arrhythmias. Premature ventricular contractions (PVCs) are an important measure in determining dise...
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| Veröffentlicht in: | Journal of cardiovascular electrophysiology 2015-01, Vol.26 (1), p.53-57 |
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| creator | CAMM, CHRISTIAN F. TICHNELL, CRYSTAL JAMES, CYNTHIA A. MURRAY, BRITTNEY PORTERFIELD, FLORENCE TE RIELE, ANNELINE S.J.M. TANDRI, HARIKRISHNA CALKINS, HUGH |
| description | PVC Variability in ARVD/C
Introduction
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is an inherited cardiomyopathy, characterized by right ventricular dysfunction and ventricular arrhythmias. Premature ventricular contractions (PVCs) are an important measure in determining disease severity and constitute a minor criterion in the 2010 Task Force Criteria for the diagnosis of ARVD/C. Little information is available regarding the variability in PVCs.
Methods and Results
Patients (n = 40) from the Johns Hopkins ARVD/C registry, meeting diagnostic criteria were included. Single lead continuous 12‐lead electrocardiogram (ECG) monitors (Zio® Patches) were applied to monitor PVC counts. Detailed demographic, phenotypic, and structural information were obtained from registry data. ECG monitors were worn for a mean period of 159.3 hours (±39.3). Average 24‐hour PVC count in this population was 1,090.5 (interquartile range = 1,711). One‐way analysis of variance demonstrated statistically significant interday variance in mean hourly PVC counts in 76% of ARVD/C‐positive subjects (28/37, 3 cases excluded due to insufficient data). Eleven individuals (27.5%) had maximum 24‐hour PVC counts of >500 with a corresponding minimum 24‐hour PVC count of |
| doi_str_mv | 10.1111/jce.12544 |
| format | Article |
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Introduction
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is an inherited cardiomyopathy, characterized by right ventricular dysfunction and ventricular arrhythmias. Premature ventricular contractions (PVCs) are an important measure in determining disease severity and constitute a minor criterion in the 2010 Task Force Criteria for the diagnosis of ARVD/C. Little information is available regarding the variability in PVCs.
Methods and Results
Patients (n = 40) from the Johns Hopkins ARVD/C registry, meeting diagnostic criteria were included. Single lead continuous 12‐lead electrocardiogram (ECG) monitors (Zio® Patches) were applied to monitor PVC counts. Detailed demographic, phenotypic, and structural information were obtained from registry data. ECG monitors were worn for a mean period of 159.3 hours (±39.3). Average 24‐hour PVC count in this population was 1,090.5 (interquartile range = 1,711). One‐way analysis of variance demonstrated statistically significant interday variance in mean hourly PVC counts in 76% of ARVD/C‐positive subjects (28/37, 3 cases excluded due to insufficient data). Eleven individuals (27.5%) had maximum 24‐hour PVC counts of >500 with a corresponding minimum 24‐hour PVC count of <500. The average 24‐hour PVC count for each patient was derived for each day recorded. The 24‐hour PVC count placed 89.6% of counts (223/249) on the correct side of the 500‐PVC count.
Conclusion
Statistically significant variation between 24‐hour PVC counts is present in the ARVD/C population. However, 24‐hour ECG monitoring was sufficient to identify 89.6% of 24‐hour periods to the correct grouping based on 2010 Task Force Criteria.</description><identifier>ISSN: 1045-3873</identifier><identifier>EISSN: 1540-8167</identifier><identifier>DOI: 10.1111/jce.12544</identifier><identifier>PMID: 25215858</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Action Potentials ; Adult ; Aged ; Arrhythmogenic Right Ventricular Dysplasia - complications ; Arrhythmogenic Right Ventricular Dysplasia - diagnosis ; Arrhythmogenic Right Ventricular Dysplasia - physiopathology ; arrhythmogenic right ventricular dysplasia/cardiomyopathy ; Baltimore ; Electrocardiography, Ambulatory ; Female ; Heart Rate ; Holter ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; premature ventricular contractions ; Registries ; Risk Factors ; Time Factors ; variability ; Ventricular Function, Right ; Ventricular Premature Complexes - diagnosis ; Ventricular Premature Complexes - etiology ; Ventricular Premature Complexes - physiopathology</subject><ispartof>Journal of cardiovascular electrophysiology, 2015-01, Vol.26 (1), p.53-57</ispartof><rights>2014 Wiley Periodicals, Inc.</rights><rights>Journal compilation © 2015 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4574-2b4a9f72974d4af0bbb0719c82c64eeaf1d13cfbd31e463eb9ff641ed761f5763</citedby><cites>FETCH-LOGICAL-c4574-2b4a9f72974d4af0bbb0719c82c64eeaf1d13cfbd31e463eb9ff641ed761f5763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjce.12544$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjce.12544$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25215858$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CAMM, CHRISTIAN F.</creatorcontrib><creatorcontrib>TICHNELL, CRYSTAL</creatorcontrib><creatorcontrib>JAMES, CYNTHIA A.</creatorcontrib><creatorcontrib>MURRAY, BRITTNEY</creatorcontrib><creatorcontrib>PORTERFIELD, FLORENCE</creatorcontrib><creatorcontrib>TE RIELE, ANNELINE S.J.M.</creatorcontrib><creatorcontrib>TANDRI, HARIKRISHNA</creatorcontrib><creatorcontrib>CALKINS, HUGH</creatorcontrib><title>Premature Ventricular Contraction Variability in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy</title><title>Journal of cardiovascular electrophysiology</title><addtitle>J Cardiovasc Electrophysiol</addtitle><description>PVC Variability in ARVD/C
Introduction
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is an inherited cardiomyopathy, characterized by right ventricular dysfunction and ventricular arrhythmias. Premature ventricular contractions (PVCs) are an important measure in determining disease severity and constitute a minor criterion in the 2010 Task Force Criteria for the diagnosis of ARVD/C. Little information is available regarding the variability in PVCs.
Methods and Results
Patients (n = 40) from the Johns Hopkins ARVD/C registry, meeting diagnostic criteria were included. Single lead continuous 12‐lead electrocardiogram (ECG) monitors (Zio® Patches) were applied to monitor PVC counts. Detailed demographic, phenotypic, and structural information were obtained from registry data. ECG monitors were worn for a mean period of 159.3 hours (±39.3). Average 24‐hour PVC count in this population was 1,090.5 (interquartile range = 1,711). One‐way analysis of variance demonstrated statistically significant interday variance in mean hourly PVC counts in 76% of ARVD/C‐positive subjects (28/37, 3 cases excluded due to insufficient data). Eleven individuals (27.5%) had maximum 24‐hour PVC counts of >500 with a corresponding minimum 24‐hour PVC count of <500. The average 24‐hour PVC count for each patient was derived for each day recorded. The 24‐hour PVC count placed 89.6% of counts (223/249) on the correct side of the 500‐PVC count.
Conclusion
Statistically significant variation between 24‐hour PVC counts is present in the ARVD/C population. However, 24‐hour ECG monitoring was sufficient to identify 89.6% of 24‐hour periods to the correct grouping based on 2010 Task Force Criteria.</description><subject>Action Potentials</subject><subject>Adult</subject><subject>Aged</subject><subject>Arrhythmogenic Right Ventricular Dysplasia - complications</subject><subject>Arrhythmogenic Right Ventricular Dysplasia - diagnosis</subject><subject>Arrhythmogenic Right Ventricular Dysplasia - physiopathology</subject><subject>arrhythmogenic right ventricular dysplasia/cardiomyopathy</subject><subject>Baltimore</subject><subject>Electrocardiography, Ambulatory</subject><subject>Female</subject><subject>Heart Rate</subject><subject>Holter</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Predictive Value of Tests</subject><subject>premature ventricular contractions</subject><subject>Registries</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>variability</subject><subject>Ventricular Function, Right</subject><subject>Ventricular Premature Complexes - diagnosis</subject><subject>Ventricular Premature Complexes - etiology</subject><subject>Ventricular Premature Complexes - physiopathology</subject><issn>1045-3873</issn><issn>1540-8167</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAUhS0EoqWw4AVQJDZlkY4d_2WWVVoKVfkRGgpiYznOdcdDEg-2ozZvj8u0lUDCG9_Fdz5f-SD0kuAjks9iY-CIVJyxR2ifcIbLmgj5OM-Y8ZLWku6hZzFuMCZUYP4U7VW8Irzm9T7afA4w6DQFKC5hTMGZqdehaHyetUnOj8WlDk63rndpLtxYHIewntN68FcwOlN8cVfr9Ff2ZI7bXkenF40OnfPD7Lc6refn6InVfYQXd_cB-vr2dNW8Ky8-nb1vji9Kw7hkZdUyvbSyWkrWMW1x27ZYkqWpKyMYgLakI9TYtqMEmKDQLq0VjEAnBbFcCnqADnfebfC_JohJDS4a6Hs9gp-iIiK_I1lF64y-_gfd-CmMebtbilIqsjlTb3aUCT7GAFZtgxt0mBXB6rYAlQtQfwrI7Ks749QO0D2Q9z-egcUOuHY9zP83qfPm9F5Z7hIuJrh5SOjwUwlJJVffPp6p89WPVf39Q6VO6G-S2KCQ</recordid><startdate>201501</startdate><enddate>201501</enddate><creator>CAMM, CHRISTIAN F.</creator><creator>TICHNELL, CRYSTAL</creator><creator>JAMES, CYNTHIA A.</creator><creator>MURRAY, BRITTNEY</creator><creator>PORTERFIELD, FLORENCE</creator><creator>TE RIELE, ANNELINE S.J.M.</creator><creator>TANDRI, HARIKRISHNA</creator><creator>CALKINS, HUGH</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201501</creationdate><title>Premature Ventricular Contraction Variability in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy</title><author>CAMM, CHRISTIAN F. ; TICHNELL, CRYSTAL ; JAMES, CYNTHIA A. ; MURRAY, BRITTNEY ; PORTERFIELD, FLORENCE ; TE RIELE, ANNELINE S.J.M. ; TANDRI, HARIKRISHNA ; CALKINS, HUGH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4574-2b4a9f72974d4af0bbb0719c82c64eeaf1d13cfbd31e463eb9ff641ed761f5763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Action Potentials</topic><topic>Adult</topic><topic>Aged</topic><topic>Arrhythmogenic Right Ventricular Dysplasia - complications</topic><topic>Arrhythmogenic Right Ventricular Dysplasia - diagnosis</topic><topic>Arrhythmogenic Right Ventricular Dysplasia - physiopathology</topic><topic>arrhythmogenic right ventricular dysplasia/cardiomyopathy</topic><topic>Baltimore</topic><topic>Electrocardiography, Ambulatory</topic><topic>Female</topic><topic>Heart Rate</topic><topic>Holter</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Predictive Value of Tests</topic><topic>premature ventricular contractions</topic><topic>Registries</topic><topic>Risk Factors</topic><topic>Time Factors</topic><topic>variability</topic><topic>Ventricular Function, Right</topic><topic>Ventricular Premature Complexes - diagnosis</topic><topic>Ventricular Premature Complexes - etiology</topic><topic>Ventricular Premature Complexes - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CAMM, CHRISTIAN F.</creatorcontrib><creatorcontrib>TICHNELL, CRYSTAL</creatorcontrib><creatorcontrib>JAMES, CYNTHIA A.</creatorcontrib><creatorcontrib>MURRAY, BRITTNEY</creatorcontrib><creatorcontrib>PORTERFIELD, FLORENCE</creatorcontrib><creatorcontrib>TE RIELE, ANNELINE S.J.M.</creatorcontrib><creatorcontrib>TANDRI, HARIKRISHNA</creatorcontrib><creatorcontrib>CALKINS, HUGH</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiovascular electrophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CAMM, CHRISTIAN F.</au><au>TICHNELL, CRYSTAL</au><au>JAMES, CYNTHIA A.</au><au>MURRAY, BRITTNEY</au><au>PORTERFIELD, FLORENCE</au><au>TE RIELE, ANNELINE S.J.M.</au><au>TANDRI, HARIKRISHNA</au><au>CALKINS, HUGH</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Premature Ventricular Contraction Variability in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy</atitle><jtitle>Journal of cardiovascular electrophysiology</jtitle><addtitle>J Cardiovasc Electrophysiol</addtitle><date>2015-01</date><risdate>2015</risdate><volume>26</volume><issue>1</issue><spage>53</spage><epage>57</epage><pages>53-57</pages><issn>1045-3873</issn><eissn>1540-8167</eissn><abstract>PVC Variability in ARVD/C
Introduction
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is an inherited cardiomyopathy, characterized by right ventricular dysfunction and ventricular arrhythmias. Premature ventricular contractions (PVCs) are an important measure in determining disease severity and constitute a minor criterion in the 2010 Task Force Criteria for the diagnosis of ARVD/C. Little information is available regarding the variability in PVCs.
Methods and Results
Patients (n = 40) from the Johns Hopkins ARVD/C registry, meeting diagnostic criteria were included. Single lead continuous 12‐lead electrocardiogram (ECG) monitors (Zio® Patches) were applied to monitor PVC counts. Detailed demographic, phenotypic, and structural information were obtained from registry data. ECG monitors were worn for a mean period of 159.3 hours (±39.3). Average 24‐hour PVC count in this population was 1,090.5 (interquartile range = 1,711). One‐way analysis of variance demonstrated statistically significant interday variance in mean hourly PVC counts in 76% of ARVD/C‐positive subjects (28/37, 3 cases excluded due to insufficient data). Eleven individuals (27.5%) had maximum 24‐hour PVC counts of >500 with a corresponding minimum 24‐hour PVC count of <500. The average 24‐hour PVC count for each patient was derived for each day recorded. The 24‐hour PVC count placed 89.6% of counts (223/249) on the correct side of the 500‐PVC count.
Conclusion
Statistically significant variation between 24‐hour PVC counts is present in the ARVD/C population. However, 24‐hour ECG monitoring was sufficient to identify 89.6% of 24‐hour periods to the correct grouping based on 2010 Task Force Criteria.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25215858</pmid><doi>10.1111/jce.12544</doi><tpages>5</tpages></addata></record> |
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| subjects | Action Potentials Adult Aged Arrhythmogenic Right Ventricular Dysplasia - complications Arrhythmogenic Right Ventricular Dysplasia - diagnosis Arrhythmogenic Right Ventricular Dysplasia - physiopathology arrhythmogenic right ventricular dysplasia/cardiomyopathy Baltimore Electrocardiography, Ambulatory Female Heart Rate Holter Humans Male Middle Aged Predictive Value of Tests premature ventricular contractions Registries Risk Factors Time Factors variability Ventricular Function, Right Ventricular Premature Complexes - diagnosis Ventricular Premature Complexes - etiology Ventricular Premature Complexes - physiopathology |
| title | Premature Ventricular Contraction Variability in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy |
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