Inhibitors of p21-activated kinases (PAKs)

The p21-activated kinase (PAK) family of serine/threonine protein kinases plays important roles in cytoskeletal organization, cellular morphogenesis, and survival, and members of this family have been implicated in many diseases including cancer, infectious diseases, and neurological disorders. Owin...

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Veröffentlicht in:	Journal of medicinal chemistry 2015-01, Vol.58 (1), p.111-129
Hauptverfasser:	Rudolph, Joachim, Crawford, James J, Hoeflich, Klaus P, Wang, Weiru
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Proliferation - drug effects Cell Survival - drug effects Humans Isoenzymes - antagonists & inhibitors Isoenzymes - chemistry Isoenzymes - metabolism Models, Biological Models, Molecular Molecular Structure Neoplasms - drug therapy Neoplasms - pathology p21-Activated Kinases - antagonists & inhibitors p21-Activated Kinases - chemistry p21-Activated Kinases - metabolism Protein Binding Protein Isoforms - antagonists & inhibitors Protein Isoforms - metabolism Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - metabolism Protein Kinase Inhibitors - pharmacology Protein Structure, Tertiary Signal Transduction - drug effects
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