Development of a sensitive LC-MS/MS method for simultaneous quantification of eleven constituents in rat serum and its application to a pharmacokinetic study of a Chinese medicine Shengmai injection

A sensitive LC‐MS/MS method was developed and validated for simultaneous quantification of 11 constituents, ginsenoside Rg1, Re, Rf, Rg2, Rb1, Rd, Rc, ophiopogonin D, schisandrin, schisandrol B and schizandrin B, in rat serum using digoxin as the internal standard (IS). The serum samples were pretre...

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Veröffentlicht in:	Biomedical chromatography 2015-02, Vol.29 (2), p.275-284
Hauptverfasser:	Zhan, Shuyu, Shao, Qing, Fan, Xiaohui, Li, Zheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromatography, Liquid - methods ginsenoside Ginsenosides - blood LC-MS/MS lignan Lignans - blood ophiopogonin pharmacokinetics Rats Saponins - blood Shengmai injection Tandem Mass Spectrometry - methods
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