HLA-B38 and clozapine-induced agranulocytosis in Israeli Jewish schizophrenic patients
To further substantiate reports of an association between the major histocompatibility complex subtypes and clozapine‐induced agranulocytosis, HLA typing was performed in 61 Jewish Israeli schizophrenic patients, in 11 of whom agranulocytosis developed following clozapine treatment and in 50 (contro...
Gespeichert in:
| Veröffentlicht in: | European journal of immunogenetics 1998-02, Vol.25 (1), p.11-13 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 13 |
|---|---|
| container_issue | 1 |
| container_start_page | 11 |
| container_title | European journal of immunogenetics |
| container_volume | 25 |
| creator | Valevski, A. Klein, T. Gazit, E. Meged, S. Stein, D. Elizur, A. Narinsky, E.R. Kutzuk, D. Weizman, A. |
| description | To further substantiate reports of an association between the major histocompatibility complex subtypes and clozapine‐induced agranulocytosis, HLA typing was performed in 61 Jewish Israeli schizophrenic patients, in 11 of whom agranulocytosis developed following clozapine treatment and in 50 (controls) of whom it did not. Of the 11 agranulocytosis patients, seven (63%) were of Ashkenazi origin and four (37%) of Sephardi origin. There was no difference in ethnic origin between the agranulocytosis and non‐agranulocytosis groups (χ2 = 2.4, d.f. = 1, P = 0.11), although the agranulocytosis patients had a higher frequency of the HLA B38 antigen (8/11 or 72% vs. 6/50 or 12%; χ2 = 18.7, d.f. = 1, P < 0.001). These results suggest that major histocompatibility complex gene products could be involved in clozapine‐mediated haematological complications. |
| doi_str_mv | 10.1046/j.1365-2370.1998.00091.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_16456916</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>16456916</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4961-29824268f2f0f2b86e1c01fb9e7e15b3646db4b140406575c0055663a23f8bb03</originalsourceid><addsrcrecordid>eNqNkF1r2zAUhsXY6NJuP6Ggi7I7p0eflqA3Xba1KaFlsI_eCVmWF2WO7Uk2Tfrr6zQh17vSQe_zngMPQpjAlACXl6spYVJklOXjh9ZqCgCaTDdv0OQYvEUT0BKynFN4j05TWgEQRrQ8QSdaqDznMEG_bhfX2WemsG1K7Or22Xah8VloysH5Ets_0TZD3bpt36aQcGjwPEXr64Dv_FNIS5zcMjy33TL6Jjjc2T74pk8f0LvK1sl_PLxn6Oe3rz9mt9ni4WY-u15kjmtJMqoV5VSqilZQ0UJJTxyQqtA-90QUTHJZFrwgHDhIkQsHIISUzFJWqaIAdoY-7fd2sf03-NSbdUjO17VtfDskQyQXUhM5gmoPutimFH1luhjWNm4NAbNTalZmZ87szJmdUvOq1GzG6vnhxlCsfXksHhyO-cUht8nZuhqNuZCOGKUAnPARu9pjT6H22_8-b-Z383EY69m-HlLvN8e6jX-NzFkuzO_7G_Od6McZV18MsBdy558s</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16456916</pqid></control><display><type>article</type><title>HLA-B38 and clozapine-induced agranulocytosis in Israeli Jewish schizophrenic patients</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Valevski, A. ; Klein, T. ; Gazit, E. ; Meged, S. ; Stein, D. ; Elizur, A. ; Narinsky, E.R. ; Kutzuk, D. ; Weizman, A.</creator><creatorcontrib>Valevski, A. ; Klein, T. ; Gazit, E. ; Meged, S. ; Stein, D. ; Elizur, A. ; Narinsky, E.R. ; Kutzuk, D. ; Weizman, A.</creatorcontrib><description>To further substantiate reports of an association between the major histocompatibility complex subtypes and clozapine‐induced agranulocytosis, HLA typing was performed in 61 Jewish Israeli schizophrenic patients, in 11 of whom agranulocytosis developed following clozapine treatment and in 50 (controls) of whom it did not. Of the 11 agranulocytosis patients, seven (63%) were of Ashkenazi origin and four (37%) of Sephardi origin. There was no difference in ethnic origin between the agranulocytosis and non‐agranulocytosis groups (χ2 = 2.4, d.f. = 1, P = 0.11), although the agranulocytosis patients had a higher frequency of the HLA B38 antigen (8/11 or 72% vs. 6/50 or 12%; χ2 = 18.7, d.f. = 1, P < 0.001). These results suggest that major histocompatibility complex gene products could be involved in clozapine‐mediated haematological complications.</description><identifier>ISSN: 0960-7420</identifier><identifier>EISSN: 1365-2370</identifier><identifier>DOI: 10.1046/j.1365-2370.1998.00091.x</identifier><identifier>PMID: 9587740</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adult ; Adult and adolescent clinical studies ; Agranulocytosis - chemically induced ; Agranulocytosis - ethnology ; Agranulocytosis - genetics ; Antipsychotic Agents - adverse effects ; Antipsychotic Agents - therapeutic use ; Biological and medical sciences ; Clozapine - adverse effects ; Clozapine - therapeutic use ; Female ; Genes, MHC Class I - genetics ; Genes, MHC Class II - genetics ; Genetic Predisposition to Disease ; Haplotypes ; Histocompatibility Testing ; HLA-B Antigens - genetics ; HLA-B38 Antigen ; Humans ; Israel ; Jews - genetics ; Male ; Medical sciences ; Middle Aged ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Schizophrenia ; Schizophrenia - drug therapy ; Schizophrenia - ethnology ; Schizophrenia - genetics</subject><ispartof>European journal of immunogenetics, 1998-02, Vol.25 (1), p.11-13</ispartof><rights>1998 Blackwell Science Ltd</rights><rights>1998 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4961-29824268f2f0f2b86e1c01fb9e7e15b3646db4b140406575c0055663a23f8bb03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2370.1998.00091.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2370.1998.00091.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,1417,23930,23931,25140,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2200414$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9587740$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Valevski, A.</creatorcontrib><creatorcontrib>Klein, T.</creatorcontrib><creatorcontrib>Gazit, E.</creatorcontrib><creatorcontrib>Meged, S.</creatorcontrib><creatorcontrib>Stein, D.</creatorcontrib><creatorcontrib>Elizur, A.</creatorcontrib><creatorcontrib>Narinsky, E.R.</creatorcontrib><creatorcontrib>Kutzuk, D.</creatorcontrib><creatorcontrib>Weizman, A.</creatorcontrib><title>HLA-B38 and clozapine-induced agranulocytosis in Israeli Jewish schizophrenic patients</title><title>European journal of immunogenetics</title><addtitle>Eur J Immunogenet</addtitle><description>To further substantiate reports of an association between the major histocompatibility complex subtypes and clozapine‐induced agranulocytosis, HLA typing was performed in 61 Jewish Israeli schizophrenic patients, in 11 of whom agranulocytosis developed following clozapine treatment and in 50 (controls) of whom it did not. Of the 11 agranulocytosis patients, seven (63%) were of Ashkenazi origin and four (37%) of Sephardi origin. There was no difference in ethnic origin between the agranulocytosis and non‐agranulocytosis groups (χ2 = 2.4, d.f. = 1, P = 0.11), although the agranulocytosis patients had a higher frequency of the HLA B38 antigen (8/11 or 72% vs. 6/50 or 12%; χ2 = 18.7, d.f. = 1, P < 0.001). These results suggest that major histocompatibility complex gene products could be involved in clozapine‐mediated haematological complications.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Agranulocytosis - chemically induced</subject><subject>Agranulocytosis - ethnology</subject><subject>Agranulocytosis - genetics</subject><subject>Antipsychotic Agents - adverse effects</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Clozapine - adverse effects</subject><subject>Clozapine - therapeutic use</subject><subject>Female</subject><subject>Genes, MHC Class I - genetics</subject><subject>Genes, MHC Class II - genetics</subject><subject>Genetic Predisposition to Disease</subject><subject>Haplotypes</subject><subject>Histocompatibility Testing</subject><subject>HLA-B Antigens - genetics</subject><subject>HLA-B38 Antigen</subject><subject>Humans</subject><subject>Israel</subject><subject>Jews - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Schizophrenia</subject><subject>Schizophrenia - drug therapy</subject><subject>Schizophrenia - ethnology</subject><subject>Schizophrenia - genetics</subject><issn>0960-7420</issn><issn>1365-2370</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1r2zAUhsXY6NJuP6Ggi7I7p0eflqA3Xba1KaFlsI_eCVmWF2WO7Uk2Tfrr6zQh17vSQe_zngMPQpjAlACXl6spYVJklOXjh9ZqCgCaTDdv0OQYvEUT0BKynFN4j05TWgEQRrQ8QSdaqDznMEG_bhfX2WemsG1K7Or22Xah8VloysH5Ets_0TZD3bpt36aQcGjwPEXr64Dv_FNIS5zcMjy33TL6Jjjc2T74pk8f0LvK1sl_PLxn6Oe3rz9mt9ni4WY-u15kjmtJMqoV5VSqilZQ0UJJTxyQqtA-90QUTHJZFrwgHDhIkQsHIISUzFJWqaIAdoY-7fd2sf03-NSbdUjO17VtfDskQyQXUhM5gmoPutimFH1luhjWNm4NAbNTalZmZ87szJmdUvOq1GzG6vnhxlCsfXksHhyO-cUht8nZuhqNuZCOGKUAnPARu9pjT6H22_8-b-Z383EY69m-HlLvN8e6jX-NzFkuzO_7G_Od6McZV18MsBdy558s</recordid><startdate>199802</startdate><enddate>199802</enddate><creator>Valevski, A.</creator><creator>Klein, T.</creator><creator>Gazit, E.</creator><creator>Meged, S.</creator><creator>Stein, D.</creator><creator>Elizur, A.</creator><creator>Narinsky, E.R.</creator><creator>Kutzuk, D.</creator><creator>Weizman, A.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>199802</creationdate><title>HLA-B38 and clozapine-induced agranulocytosis in Israeli Jewish schizophrenic patients</title><author>Valevski, A. ; Klein, T. ; Gazit, E. ; Meged, S. ; Stein, D. ; Elizur, A. ; Narinsky, E.R. ; Kutzuk, D. ; Weizman, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4961-29824268f2f0f2b86e1c01fb9e7e15b3646db4b140406575c0055663a23f8bb03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Agranulocytosis - chemically induced</topic><topic>Agranulocytosis - ethnology</topic><topic>Agranulocytosis - genetics</topic><topic>Antipsychotic Agents - adverse effects</topic><topic>Antipsychotic Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Clozapine - adverse effects</topic><topic>Clozapine - therapeutic use</topic><topic>Female</topic><topic>Genes, MHC Class I - genetics</topic><topic>Genes, MHC Class II - genetics</topic><topic>Genetic Predisposition to Disease</topic><topic>Haplotypes</topic><topic>Histocompatibility Testing</topic><topic>HLA-B Antigens - genetics</topic><topic>HLA-B38 Antigen</topic><topic>Humans</topic><topic>Israel</topic><topic>Jews - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Schizophrenia</topic><topic>Schizophrenia - drug therapy</topic><topic>Schizophrenia - ethnology</topic><topic>Schizophrenia - genetics</topic><toplevel>online_resources</toplevel><creatorcontrib>Valevski, A.</creatorcontrib><creatorcontrib>Klein, T.</creatorcontrib><creatorcontrib>Gazit, E.</creatorcontrib><creatorcontrib>Meged, S.</creatorcontrib><creatorcontrib>Stein, D.</creatorcontrib><creatorcontrib>Elizur, A.</creatorcontrib><creatorcontrib>Narinsky, E.R.</creatorcontrib><creatorcontrib>Kutzuk, D.</creatorcontrib><creatorcontrib>Weizman, A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>European journal of immunogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Valevski, A.</au><au>Klein, T.</au><au>Gazit, E.</au><au>Meged, S.</au><au>Stein, D.</au><au>Elizur, A.</au><au>Narinsky, E.R.</au><au>Kutzuk, D.</au><au>Weizman, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA-B38 and clozapine-induced agranulocytosis in Israeli Jewish schizophrenic patients</atitle><jtitle>European journal of immunogenetics</jtitle><addtitle>Eur J Immunogenet</addtitle><date>1998-02</date><risdate>1998</risdate><volume>25</volume><issue>1</issue><spage>11</spage><epage>13</epage><pages>11-13</pages><issn>0960-7420</issn><eissn>1365-2370</eissn><abstract>To further substantiate reports of an association between the major histocompatibility complex subtypes and clozapine‐induced agranulocytosis, HLA typing was performed in 61 Jewish Israeli schizophrenic patients, in 11 of whom agranulocytosis developed following clozapine treatment and in 50 (controls) of whom it did not. Of the 11 agranulocytosis patients, seven (63%) were of Ashkenazi origin and four (37%) of Sephardi origin. There was no difference in ethnic origin between the agranulocytosis and non‐agranulocytosis groups (χ2 = 2.4, d.f. = 1, P = 0.11), although the agranulocytosis patients had a higher frequency of the HLA B38 antigen (8/11 or 72% vs. 6/50 or 12%; χ2 = 18.7, d.f. = 1, P < 0.001). These results suggest that major histocompatibility complex gene products could be involved in clozapine‐mediated haematological complications.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>9587740</pmid><doi>10.1046/j.1365-2370.1998.00091.x</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-7420 |
| ispartof | European journal of immunogenetics, 1998-02, Vol.25 (1), p.11-13 |
| issn | 0960-7420 1365-2370 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16456916 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adult Adult and adolescent clinical studies Agranulocytosis - chemically induced Agranulocytosis - ethnology Agranulocytosis - genetics Antipsychotic Agents - adverse effects Antipsychotic Agents - therapeutic use Biological and medical sciences Clozapine - adverse effects Clozapine - therapeutic use Female Genes, MHC Class I - genetics Genes, MHC Class II - genetics Genetic Predisposition to Disease Haplotypes Histocompatibility Testing HLA-B Antigens - genetics HLA-B38 Antigen Humans Israel Jews - genetics Male Medical sciences Middle Aged Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - drug therapy Schizophrenia - ethnology Schizophrenia - genetics |
| title | HLA-B38 and clozapine-induced agranulocytosis in Israeli Jewish schizophrenic patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T02%3A54%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=HLA-B38%20and%20clozapine-induced%20agranulocytosis%20in%20Israeli%20Jewish%20schizophrenic%20patients&rft.jtitle=European%20journal%20of%20immunogenetics&rft.au=Valevski,%20A.&rft.date=1998-02&rft.volume=25&rft.issue=1&rft.spage=11&rft.epage=13&rft.pages=11-13&rft.issn=0960-7420&rft.eissn=1365-2370&rft_id=info:doi/10.1046/j.1365-2370.1998.00091.x&rft_dat=%3Cproquest_cross%3E16456916%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16456916&rft_id=info:pmid/9587740&rfr_iscdi=true |